Notes in 04 ANS PHA

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Status	Last Update	Fields
Published	07/30/2024	Synthesis of NE and E Substrate/ProductEnzyme{{c1::Phenylalanine}}↓{{c1::Phenylalanine hydroxylase}}{{c2::Tyrosine}}↓{{c2::Ty…
Published	07/30/2024	Muscarinic ReceptorsReceptor: M1Found in: {{c2::Secretory glands, Nerve Endings}}Postreceptor mechanism: ↑ IP3-DAG
Published	07/30/2024	Muscarinic ReceptorsReceptor: M2Found in: {{c1::Supraventricular muscles (heart)}}Postreceptor mechanism: ↓ cAMP, K+ channel activation
Published	07/30/2024	Muscarinic ReceptorsReceptor: M3Found in: {{c1::Smooth muscles of blood vessels and glands}}Postreceptor mechanism: ↑ IP3-DAG
Published	07/30/2024	Muscarinic ReceptorsReceptor: Nn or N{{c1::2}}Found in: Neuronal ANS GangliaPostreceptor mechanism: {{c1::Na+, K+ channel activation}}
Published	07/30/2024	Muscarinic ReceptorsReceptor: Nm or N{{c1::1}}Found in: Skeletal Muscle (at the Neuromuscular Endplate)Postreceptor mechanism: {{c1::Na…
Published	07/30/2024	Adrenergic ReceptorsReceptor: α1Found in: {{c1::Smooth muscles (BV, GIT, GUT,), piloerector, radial muscle, apocrine sweat glands}}Postrecep…
Published	07/30/2024	Muscarinic ReceptorsReceptor: α2Found in: {{c1::Presynaptic Adrenergic Terminals, Platelets, Lipocytes, Smooth Muscles}}Postreceptor mechani…
Published	07/30/2024	Muscarinic ReceptorsReceptor: β1Found in: {{c1::Heart, Ciliary Body, Brain, Kidney}}Postreceptor mechanism: ↑ cAMP
Published	07/30/2024	Adrenergic ReceptorsReceptor: β2Found in: {{c1::Smooth muscles (Lungs, Uterus), Glands (Liver, Pancreas)}}Postreceptor mechanism: …
Published	07/30/2024	Muscarinic ReceptorsReceptor: β3Found in: {{c1::Lipocytes, Bladder}}Postreceptor mechanism: ↑ cAMP
Published	07/30/2024	Guide to "mano-mano" of Effect of an ANS receptor on an organIf the subscript is 1, it is {{c1::excita::inhibi/excita}}toryIf the subscript is 2, it i…
Published	07/30/2024	Ways to Affect ANS TransmissionJust read this stuff{{c1::SSRRBB}}
Published	07/30/2024	{{c1::Beta-phenylethylamine}} is the parent compound of sympathomimetic drugs
Published	07/30/2024	Representative Direct Non-selective Sympathomimetic Drug/s: {{c1::NE, E, Ephedrine (Considered "Dual-acting")}}
Published	07/30/2024	Representative Direct Alpha-1 Agonist Drug/s: {{c1::Midodrine}}
Published	07/30/2024	Representative Direct Alpha-2 Agonist Drug/s: {{c1::Clonidine}}
Published	07/30/2024	Representative Direct Beta-1 Agonist Drug/s: {{c1::Dobutamine}}
Published	07/30/2024	Representative Direct Beta-2 Agonist Drug/s: {{c1::Terbutaline, Isoproterenol}}
Published	07/30/2024	Representative Indirect Sympathomimetic Drug/s: {{c1::Amphetamine and Cocaine}}
Published	07/30/2024	Why is it important to only give Beta-2 blockers at normal therapeutic concentrations?{{c1::Selectivity ONLY occurs at normal therapeutic concentratio…
Published	07/30/2024	EpinephrineMOA: {{c1::Mixed Alpha and Beta Agonists}}Clinical Application: {{c1::Asthma, Allergies, Anaphylaxis}}
Published	07/30/2024	PseudoephedrineMOA: {{c1::NE release}}Clinical Application: {{c1::Rhinitis, Colds, Decongestant}}
Published	07/30/2024	PseudoephedrineMOA: {{c1::Alpha-1 Agonist}}Clinical Application: {{c1::Rhinitis, Colds, Decongestant, and Vassopressor}}
Published	07/30/2024	AmphetaminesMOA: {{c1::Ne reuptake antagonist}}Clinical Application: {{c1::Pang-Adik, Narcolepsy, Attention Deficiency Hyperkinesis}}
Published	07/30/2024	ClonidineMOA: {{c1::Alpha-2 Agonist}}Clinical Application: {{c1::HPN}}
Published	07/30/2024	Representative Non-selective Alpha Sympatholytic Drug/s: {{c1::Phenoxybenzamine, Phentolamine}}
Published	07/30/2024	Representative Alpha-1 Antagonist Drug/s: {{c1::Prazosin}}
Published	07/30/2024	Representative Alpha-2 Antagonist Drug/s: {{c1::Yohimbine, Rauwolscine}}
Published	07/30/2024	Representative Beta-1 Antagonist Drug/s: {{c1::Metoprolol, Atenolol, Acebutolol, Esmolol}}
Published	07/30/2024	Representative Non-selective Beta Sympatholytic Drug/s: {{c1::Propranolol, Nadolol, Timolol}}
Published	07/30/2024	PhenoxybenzamineMOA: {{c1::Irreversible Non-selective Alpha Antagonist}}Clinical Application: {{c1::Given before an operation. Also, malignant hyperte…
Published	07/30/2024	PhentolamineMOA: {{c1::Reversible Non-selective Alpha Antagonist}}Clinical Application: {{c1::Given during an operation. Also, malignant hypertension …
Published	07/30/2024	[QC] Strength1. Phenoxybenzamine2. Phentolamine{{c1::A}}
Published	07/30/2024	[QC] Reflex tachycardia and postural HPN1. Phenoxybenzamine, Phentolamine2. Prazosin{{c1::A}}
Published	07/30/2024	[QC] Reflex tachycardia and postural HPN1. Phenoxybenzamine, Phentolamine2. Prazosin{{c1::A}}
Published	07/30/2024	PrazosinMOA: {{c1::Alpha-1 Antagonist}}Clinical Application: {{c1::HPN}}
Published	07/30/2024	Propranolol, Nadolol, Timolol (PNT)MOA: {{c1::Non-selective Beta Antagonist}}Clinical Application: {{c1::HPN, angina, migraine headaches and mitral va…
Published	07/30/2024	Metoprolol, Atenolol, Acebutolol, EsmololMOA: {{c1::Beta-1 Antagonist}}Clinical Application: {{c1::HPN for px with respiratory disorders}}
Published	07/30/2024	ReserpineMOA: {{c1::NE synthesis & storage blocker}}Clinical Application: {{c1::HPN and Sedation}}
Published	07/30/2024	Phenylethylamine → {{c1::Hydroxylation at C3 and C5 of the benzene ring::reaction}} → Catecholamine
Published	07/30/2024	Absence of one or the other hydroxyl group on phenylethylamine particularly at the {{c1::3}}-position causes marked diminution in {{c2::alpha::a/b}} a…
Published	07/30/2024	Presence of hydroxyl groups on phenylethylamine particularly at the {{c1::3 and 5}}-position causes marked selectivity in {{c2::beta::a/b}} adrenergic…
Published	07/30/2024	[VR] 1. Hydroxylation of the benzene ring of phenylethylamine derivatives2. Oral effectiveness and duration of action{{c1::B}}
Published	07/30/2024	[VR] 1. Hydroxylation of the benzene ring of phenylethylamine derivatives2. CNS effects{{c1::B}}
Published	07/30/2024	Alpha-methyl derivatives of phenylethylamine are also called {{c1::phenylisopropylamine}}
Published	07/30/2024	Substitution of the beta-carbon of phenylethylamine derivatives typical of what type of ANS agonists?{{c1::Direct acting agonists}}
Published	07/30/2024	Methyl groups on the amino group of phenylethylamine increase {{c1::Beta-2}} selectivity
Published	07/30/2024	[VR]1. Methyl groups on the amino group of phenylethylamine2. COMT metabolism{{c1::B}}
Published	07/30/2024	[QC] Beta-2 Selectivity1. E2. Isoproterenol3. Terbutaline{{c1::3 > 2 > 1}}
Published	07/30/2024	Representative Naturally-occurring Direct Cholinomimetic Drug/s: {{c1::Muscarine, Arecoline, Pilocarpine}}
Published	07/30/2024	Representative Synthetic Direct Cholinomimetic Drug/s: {{c1::Carbachol, Betanechol}}
Published	07/30/2024	Representative Short-acting Indirect Cholinomimetic (AChEi) Drug/s: {{c1::Edrophonium}}
Published	07/30/2024	Representative Medium-acting Indirect Cholinomimetic (AChEi) Drug/s: {{c1::Neostigmine, Physostigmine}}
Published	07/30/2024	Representative Long-acting Indirect Cholinomimetic (AChEi) Drug/s: {{c1::Organophosphates}}
Published	07/30/2024	Representative Noncompetitive Depolarizing Neuromuscular Blocking Cholinomimetic Drug/s: {{c1::Succinylcholine}}
Published	07/30/2024	PilocarpineMOA: {{c1::Naturally-occurring Direct Cholinomimetic}}Clinical Application: {{c1::Glaucoma}}
Published	07/30/2024	Carbachol, BetanecholMOA: {{c1::Synthetic Direct Cholinomimetic}}Clinical Application: {{c1::Atonic Bladder (Contracts urinary bladder, relaxes sphinc…
Published	07/30/2024	EdrophoniumMOA: {{c1::Short-acting Indirect Cholinomimetic (AChEi)}}Clinical Application: {{c1::Myasthenia Gravis}}
Published	07/30/2024	NeostigmineMOA: {{c1::Medium-acting Indirect Cholinomimetic (AChEi)}}Clinical Application: {{c1::Tachycardia (induces bradycardia)}}
Published	07/30/2024	PhysostigmineMOA: {{c1::Medium-acting Indirect Cholinomimetic (AChEi)}}Clinical Application: {{c1::induces secretions}}
Published	07/30/2024	SuccinylcholineMOA: {{c1::Depolarizing Neuromuscular Blocker}}Clinical Application: {{c1::Induced paralysis during ANE}}
Published	07/30/2024	Cholinergic Toxicity DOC: {{c1::Atropine, Pralidoxime}}
Published	07/30/2024	[VR] Clinical use in the context of aging1. Atropine2. Pralodoxime{{c1::A}}
Published	07/30/2024	Atropine Toxicity DOC: {{c1::Physostigmine}}
Published	07/30/2024	[QC] Lipid Solubility1. Tertiary Amines2. Quaternary Amines{{c1::A}}
Published	07/30/2024	Representative Competitive Depolarizing Neuromuscular Blocking Cholinolytic Drug/s: {{c1::Gallamin, "-curonium"}}
Status	Last Update	Fields