Notes in 03 Bone Marrow Failure, Normocytic and Macrocytic Anemias

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Published	12/14/2023	What type of anemia is seen with vitamin B9 (folate) deficiency?{{c1::Macrocytic, megaloblastic anemia}}
Published	12/14/2023	Vitamin B9 (folate) deficiency is characterized by {{c1::hypersegmented}} polymorphonuclear cells (PMNs)
Published	12/14/2023	What type of anemia is seen with vitamin B12 (cobalamin) deficiency?{{c1::Macrocytic, megaloblastic anemia}}
Published	12/14/2023	Vitamin B12 (cobalamin) deficiency is characterized by {{c1::hypersegmented}} polymorphonuclear cells (PMNs)
Published	09/03/2024	{{c1::Sideroblastic anemia}} is an anemia due to defective {{c2::protoporphyrin}} synthesis
Published	09/03/2024	Congenital sideroblastic anemia is most commonly due to a defect in the enzyme {{c1::δ-aminolevulinic acid synthase (ALAS)}}
Published	09/03/2024	What is the most common reversible cause of sideroblastic anemia? {{c1::Alcoholism}}
Published	12/14/2023	{{c2::Sideroblastic}} anemia may be caused by vitamin {{c1::B6}} deficiency
Published	09/03/2024	What mineral deficiency can cause sideroblastic anemia in patients many years after gastric bypass?{{c1::Copper deficiency}}
Published	09/03/2024	Sideroblastic anemia is a cause of {{c1::microcytic::MCV}} anemia
Published	09/03/2024	What is the treatment for sideroblastic anemia?{{c1::Pyridoxine (vitamin B6)}}
Published	09/03/2024	Impaired division and enlargement of RBC precursors leads to {{c1::megaloblastic}}, macrocytic anemia
Published	09/03/2024	Megaloblastic anemia occurs due to delayed maturation of the {{c1::nucleus}} relative to the {{c1::cytoplasm}} of precursor RBCs
Published	09/03/2024	Impaired division of granulocytic precursors in {{c2::megaloblastic}} anemia leads to {{c1::hypersegmented}} neutrophils
Published	09/03/2024	Megaloblastic anemia is a cause of {{c1::macrocytic::MCV}} anemia
Published	12/14/2023	Paroxysmal nocturnal hemoglobinuria is a cause of {{c1::normocytic::MCV}} anemia
Published	12/14/2023	What test is used to screen for paroxysmal nocturnal hemoglobinuria? {{c1::Sucrose test}}
Published	12/14/2023	Paroxysmal nocturnal hemoglobinuria is characterized by (PNH Thrombosis)- P{{c1::ancytopenia}}- N{{c4::octurnal}} build up of Red/Pink Urine - coombs …
Published	09/03/2024	What type of microcytic anemia may be caused by paroxysmal nocturnal hemoglobinuria? {{c1::Iron deficiency anemia}}
Published	12/14/2023	One cause of anemia due to underproduction is parvovirus B19, which infects progenitor red cells and temporarily halts {{c1::erythropoiesis}}
Published	09/03/2024	{{c1::Aplastic}} anemia may be induced by viral agents (e.g. parvovirus B19, EBV, HIV, hepatitis)
Published	09/03/2024	Aplastic anemia may be caused by {{c2::Fanconi}} anemia, which occurs due to a(n) defect in {{c1::dsDNA-break repair}}, resulting in bone marrow failu…
Published	09/03/2024	{{c2::Fanconi}} anemia is associated with short stature, café au lait spots, and malformed forearms and/or {{c1::thumbs}}
Published	12/14/2023	What is the most common cause of megaloblastic anemia in chronic alcoholics?{{c1::Folate deficiency}}
Published	12/14/2023	Diagnosis of paroxysmal nocturnal hemoglobinuria may be made with flow cytometry, which can detect the absence of the proteins {{c1::CD55}} and {{c1::…
Published	12/14/2023	What type of anemia is characterized by the following laboratory values?MCV: lowSerum iron: highFerritin: high{{c1::Sideroblastic anemia}}
Published	12/14/2023	{{c1::Parvovirus B19}} commonly causes {{c2::aplastic crisis}} in patients with sickle cell, thalassemias, and hereditary spherocytosis
Published	12/14/2023	In patients with leukemia, unregulated growth and differentiation of WBCs in bone marrow results in {{c1::marrow failure}}
Published	12/14/2023	"Slapped-cheek" rash in children = {{c1::parvovirus (B19)::virus}}
Published	12/14/2023	{{c1::Parvovirus (B19)::Virus}} can cause an aplastic crisis in patients with hemoglobinopathies
Published	12/14/2023	PIG-A mutation leads to {{c1::paroxysmal nocturnal hemoglobinuria::condition}}
Published	12/14/2023	The two megaloblastic anemias are {{c1::folate deficiency}} and {{c1::vitamin B12 deficiency}} and present with {{c1::hypersegmented (>5 lobes)}} n…
Published	01/02/2024	How do the following laboratory values change in sideroblastic anemia? Serum iron: {{c1::increased}}TIBC: {{c1::decreased}}% Saturation: {{c1::increas…
Published	12/14/2023	Chronic {{c1::alcohol}} consumption may cause vitamin B12 deficiency
Published	12/14/2023	Megaloblastic anemia secondary to folate/cobalamin deficiency is characterized by a(n) {{c1::low}} reticulocyte count
Published	12/14/2023	3 things that could cause malabsorption of folate and consequent megaloblastic anemia:- {{c1::IBD::decreased absorption}}- {{c1::pregnancy::…
Published	12/14/2023	To confirm diagnosis of Parvovirus B19 in an immuno-compromised individual, order {{c1::PCR}}
Published	12/14/2023	Parvovirus B19 commonly causes {{c2::pure red cell aplasia}} in immunocompromised patients
Published	12/14/2023	Pancytopenia with normal or low reticulocyte percent suggests that the etiology is {{c1::bone marrow failure::general mechanism}}
Published	12/14/2023	Pancytopenia with increased blast percent suggests that the etiology is {{c1::marrow infiltration (by malignancy)::general mechanism}}
Published	12/14/2023	Fanconi anemia typically presents with {{c1::macro}}cytic anemia
Published	12/14/2023	Fanconi anemia can present with elevated hemoglobin {{c1::F}}
Published	12/14/2023	{{c1::Bone marrow transplant}} is the only proven cure for aplastic anemia caused by Fanconi anemia or dyskeratosis congenita
Published	12/14/2023	{{c1::Androgen therapy}} is a temporary treatment for aplastic anemia caused by Fanconi anemia or dyskeratosis congenita
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