Notes in 01_Zoonotic Infections

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01_Lyme Disease
02_Leptospirosis
03_Rabies
04_Ebola

Status	Last Update	Fields
Published	02/10/2024	{{c1::Zoonotic Diseases}} are Infectious diseases transmitted naturally between {{c2::humans and animals wild or domestic}}
Published	02/10/2024	{{c1::Anthroponotic Diseases}} are diseases that are transmitted from {{c2::humans to animals}}
Published	02/10/2024	Components that underly Zoonotic Diseases {{c1::Total Viruses (Zoological pool)}} {{c1::Spillover (Ecological contact, Phylogenetic distance, Viral tr…
Published	02/10/2024	How Zoonotic Diseases are transmitted{{c1::}}
Published	02/10/2024	{{c1::Lyme Disease}} is caused by {{c2::Borrelia burgdorferi}}
Published	02/10/2024	Transmission of Lyme Disease is by {{c1::tick, Ixodes ricinus}}
Published	02/10/2024	Classic Presentation of {{c1::Lyme Disease}} is {{c2::Erythema Migrans}}
Published	02/10/2024	15% of Lyme patients develop {{c1::Neuroborreliosis}} 2-6 weeks after bite, which presents as:Triad of {{c2::facial nerve palsy}}, {{c2::radicular pai…
Published	02/10/2024	{{c1::Leptospirosis}} is caused by {{c2::Spirochete}}
Published	02/10/2024	Transmission of LeptospirosisNormally through {{c1::urine contaminated water, mud, soil}} but can occur with {{c2::direct contact with animal}}
Published	02/10/2024	General Presentation of Leptospirosis{{c1::Undifferentiated fever}}, {{c1::myalgia}}, {{c1::headaches}}, {{c1::abdominal pain}}
Published	02/10/2024	Severe Presentation of {{c2::Leptospirosis}}{{c1::Weil’s disease (triad of jaundice, AKI, bleeding)}} {{c1::Pulmonary Haemorrhage}}
Published	02/10/2024	{{c2::Rabies}} is caused by {{c1::Lyssavirus}}
Published	02/10/2024	Transmission of Rabies{{c1::The bite of an infected animal most commonly dogs, bats}}
Published	02/10/2024	Incubation of Rabies is typically {{c1::1-3 months}}
Published	02/10/2024	Presentation of {{c1::Furious Rabies}}{{c2::Hydrophobia}}{{c2::Insomnia}}{{c2::Confusion}}{{c2::Agitation}}{{c2::Coma}}
Published	02/10/2024	Presentation of {{c1::Paralytic Rabies}}{{c2::Ascending flaccid paralysis}}{{c2::Fever}}{{c2::Confusion}}{{c2::Coma}}
Published	02/10/2024	{{c1::Ebola}} is caused by {{c2::Filovirus}}
Published	02/10/2024	Incubation of Ebola is usually {{c1::2-21 days}}
Published	02/10/2024	Symptoms of {{c2::Ebola}}{{c1::}}
Published	02/10/2024	Why is Malaria not a zoonotic disease?{{c1::Malaria is not a zoonotic disease because even though transmitted from animals, they depend on the human h…
Published	02/10/2024	Investigation of Lyme DiseaseCheck for {{c1::Erythema mirgans}}, if present, commence {{c2::antibiotics}}
Published	02/10/2024	Investigation of Lyme DiseaseIf no {{c1::Erythema migrans}}, then {{c2::serology test}}
Published	02/10/2024	Investigation of Leptospirosis {{c1::Clinical high suspicion}} {{c1::Serology – IgM & IgG}} {{c1::Microscopic Agglutination Test}}
Published	02/10/2024	Investigation of Rabies {{c1::PCR of skin biopsy, saliva}} {{c1::Often post mortem confirmation – brain biopsy}}
Published	02/10/2024	Investigation of Ebola {{c1::PCR}} {{c1::Serology – IgM & IgG}}
Published	02/10/2024	First line of treatment of Lyme Disease{{c1::Doxycycline}} If they can’t take it (i.e. a child) then take {{c1::amoxicillin}}
Published	02/10/2024	Treatment of Neuro Lyme (Neuroborreliosis) is {{c1::IV Ceftriaxone}}
Published	02/10/2024	First line treatment of Leptospirosis is {{c1::Doxycycline}}
Published	02/10/2024	Second line treatment of Leptospirosis is {{c1::Amoxicillin}} or {{c1::Azithromycin}}
Published	02/10/2024	First line treatment of severe Leptospirosis is {{c1::Ceftriaxone}}
Published	02/10/2024	Treatment of Rabies{{c1::Wound cleansing}}{{c1::Active and passive immunisation after a recognised exposure}}
Published	02/10/2024	Post-exposure treatment of Rabies {{c1::Fully immunised: 2 doses: day 0, 3-7}} {{c1::Not immunised & immunocompetent: HRIG + 4 doses: days 0, 3, 7…
Published	02/10/2024	Treatment of Ebola {{c1::INMAZEB – 3 monoclonal antibodies}} {{c1::EBANGA – 1 monoclonal antibody}}
Published	02/10/2024	Vaccination of Ebola {{c1::Ervebo – 1 dose, used during an outbreak}} {{c1::Zabdeno & Mvabea – 2 doses (1 of each)}}
Status	Last Update	Fields