Notes in 01 PK

To Subscribe, use this Key

Status	Last Update	Fields
Published	07/30/2024	Component Processes of Pharmacokinetics:{{c1::Absorption}}{{c1::Distribution}}{{c1::Metabolism}}{{c1::Elimination/Excretion}}
Published	07/30/2024	Relationship of Vc, VB, and VSS ModelRelationship Single compartment{{c1::Vc = VB = VSS}}One compartment{{c1::VB > …
Published	07/30/2024	[VR]1. Molecular size of drug2. Penetration to membrane{{c1::B}}
Published	07/30/2024	[VR]1. Lipid solubility of drug2. Penetration to membrane{{c1::A}}
Published	07/30/2024	[VR]1. Membrane thickness2. Penetration {{c1::B}}
Published	07/30/2024	[QC] Penetration to membrane1. Ionized form2. Unionized form{{c1::B}}
Published	07/30/2024	[VR]1. Gastric emptying time2. Absorption{{c1::B}}
Published	07/30/2024	[VR]1. Intestinal transit time2. Absorption{{c1::A}}
Published	07/30/2024	Rectal administration that bypasses the first pass effect is through the {{c1::internal hemorrhoidal}} artery.
Published	07/30/2024	2 methods of absorption that are affected by first pass effect:{{c1::Oral}}{{c1::Rectal through the superior hemorrhoidal artery}}
Published	07/30/2024	[VR] 1. pH 2. Penetration of Weakly Acidic Drugs{{c1::B}}
Published	07/30/2024	{{c1::Bioavailability}} - Fraction of unchanged drug reaching the systemic circulation following administration by any route
Published	07/30/2024	[VR]1. First pass effect2. Bioavailability{{c1::B}}
Published	07/30/2024	Indices of Bioavailability{{c1::CMAX}} - maximum plasma drug concentration
Published	07/30/2024	Indices of Bioavailability{{c1::TMAX}} - time required to reach the maximum plasma drug concentration
Published	07/30/2024	Indices of Bioavailability{{c1::AUC}} - reflects the extent of absorption of a drug
Published	07/30/2024	Two indices of bioavailability that indicate rate of absorption of a drug:{{c1::CMAX and TMAX}}
Published	07/30/2024	Bioavalibility of IV drugs: {{c1::100%}}
Published	07/30/2024	Bioavailability equation:{{c1::}}
Published	07/30/2024	{{c1::Aminoglycoside}} - drug that has poor intestinal permeability
Published	07/30/2024	Equation for bioavalibility of oral drugs:{{c1::}}
Published	07/30/2024	[VR] 1. Extraction ratio2. Bioavailability{{c1::B}}
Published	07/30/2024	The effect of first pass elimination on F is expressed as the hepatic extraction ratio (ER):{{c1::}}
Published	07/30/2024	{{c1::Bioequivalence}} is the 90% CI of the ratios of the population average estimates of the {{c2::Cmax, Tmax, and AUC::three indices}} of a test dru…
Published	07/30/2024	Bioequivalence is pre-established in the Philippines at {{c1::80-125}}%
Published	07/30/2024	Volume of distribution equation:{{c1::}}
Published	07/30/2024	[VR]1. Binding to tissue2. Volume of distribution{{c1::A}}
Published	07/30/2024	[VR] 1. Plasma protein bound drug2. Volume of distribution{{c1::B}}
Published	07/30/2024	[VR]1. Percentage of the drug bound to protien2. Risk for drug interaction{{c1::A}}
Published	07/30/2024	Phase I metabolism are usually {{c1::oxidative}} reactions while Phase II are {{c1::conjugative}} reactions.
Published	07/30/2024	{{c1::CYP2D6}} - enzyme for antipsychotic drugs
Published	07/30/2024	{{c1::CYP2C9}} - enzyme for Warfarin
Published	07/30/2024	{{c1::CYP2C19}} - enzyme for Phenytoin
Published	07/30/2024	{{c1::Acetaldehyde dehydrogenase}} - enzyme that metabolizes alcohol
Published	07/30/2024	Filipinos are {{c1::rapid::rapid/slow}} acetylators of isoniazid
Published	07/30/2024	Clearance equation:{{c1::}}
Published	07/30/2024	Renal clearance equation:{{c1::}}
Published	07/30/2024	[VR]1. Plasma drug concentration2. Renal clearance{{c1::B}}
Published	07/30/2024	[VR]1. Plasma protein binding2. Renal clearance{{c1::B}}
Published	07/30/2024	[VR]1. Urine flow2. Renal clearance{{c1::A}}
Published	07/30/2024	[VR]1. GFR2. Renal clearance{{c1::A}}
Published	07/30/2024	Rate of excretion equation:{{c1::}}
Published	07/30/2024	Drug filtration rate equation{{c1::}}
Published	07/30/2024	Reabsorption by nonionic diffusion affects {{c1::weak acids and weak bases::substance}} while active reabsorption affects {{c1::ions::substance}}
Published	07/30/2024	If clearance is {{c1::greater::greater/lesser}} than GFR, drug is filtered and/or secreted.
Published	07/30/2024	If clearance is {{c1::lesser::greater/lesser}} than GFR, drug is reabsorbed.
Published	07/30/2024	Steady state concentration is reached at {{c1::4th-5th::N}} half lives.
Published	07/30/2024	[VR]1. Volume of distribution2. Half-life{{c1::A}}
Published	07/30/2024	[VR]1. Clearance2. Half-life{{c1::B}}
Published	07/30/2024	Half-life equation:{{c1::}}
Published	07/30/2024	[QC] Time to reach steady state 1. Short half-life2. Long half-life{{c1::B}}
Published	07/30/2024	T1/2% Plateau reached% Plateau remaining 00100150502{{c1::75}}{{c1::25}}3{{c2::87.5}}{{c2::12.5}}4{{c3::93.75}}{{c3::…
Published	07/30/2024	Css equation given Dose and Dosage interval{{c1::}}
Published	07/30/2024	[VR] In continuous IV infusion,1. Dose2. Dosage interval{{c1::B}}
Published	07/30/2024	[VR]1. Dosage interval2. Time to reach steady state{{c1::C}}
Published	07/30/2024	[VR]1. Dose2. Time to reach steady state{{c1::C}}
Published	07/30/2024	[VR]1. Rate of infusion2. Css{{c1::A}}
Published	07/30/2024	Clearance equation:{{c1::}}
Published	07/30/2024	Dosing rate equation given Cl and Css:{{c1::}}
Published	07/30/2024	Css equation given bioavailability and clearance:{{c1::}}
Published	07/30/2024	Css equation given F, Dose, Cl, T:{{c1::}}
Published	07/30/2024	Dosing rate given T, Dose, and F:{{c1::}}
Published	07/30/2024	Give the two equations for maintenance dose:{{c1::}}
Published	07/30/2024	Loading dose equation:{{c1::}}
Published	07/30/2024	In linear PK, a constant {{c1::fraction::amount/fraction}} is eliminated per unit time.
Published	07/30/2024	In non-linear PK, a constant {{c1::amount::amount/fraction}} is eliminated per unit time.
Published	07/30/2024	[VR]1. Drug concentration2. Rate of drug transfer or loss{{c1::C}}
Published	07/30/2024	{{c1::Dosage}} increases saturate binding sites and result in non-proportional increase/decrease in drug levels (saturate).
Published	07/30/2024	In Michaelis-Menten Kinetics, {{c1::linear::linear/nonlinear}} kinetic is observed at therapeutic levels while {{c1::nonlinear::linear/nonlinear}} is …
Published	07/30/2024	Two examples of drugs that exhibit Michaelis Menten Kinetics:{{c1::PhenytoinAspirin}}
Published	07/30/2024	[VR]1. pH2. Penetration of Weakly Basic Drugs{{c1::A}}
Published	07/30/2024	{{c1::Intrathecal}} injection is performed when a drug needs to reach the brain immediately
Published	07/30/2024	[VR]1. Protein Binding2. Renal Tubular Secretion{{c1::C}}
Status	Last Update	Fields