Notes in 03_PBC

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Published	02/10/2024	{{c1::Primary Biliary Cholangitis (PBC)}} is a condition where {{c2::the immune system attacks the small bile ducts within the liver.}}
Published	02/10/2024	Contents of bile duct outflow are {{c1::bile acids}}, {{c1::bilirubin}}, {{c1::cholesterol}}
Published	02/10/2024	Obstruction of bile acid flow leads to itching known as {{c1::pruritus}}
Published	02/10/2024	Obstruction of bilirubin flow leads to yellow skin and eyes known as {{c1::jaundice}}
Published	02/10/2024	Obstruction of cholesterol flow leads to {{c1::xanthelasama}} which are deposits in the skin, and {{c1::xanthomas}} which are larger nodular deposits …
Published	02/10/2024	Presentation of {{c2::Primary Biliary Cholangitis (PBC)}}{{c1::Fatigue}} {{c1::Pruritus}} {{c1::GI disturbance}} and {{c1::abdominal pain}} {{c1::Jaun…
Published	02/10/2024	Associations of Primary Biliary Cholangitis (PBC){{c1::Middle aged women}} {{c1::Autoimmune diseases (e.g. thyroid, coeliac)}}  {{…
Published	02/10/2024	Complications of Primary Biliary Cholangitis (PBC){{c1::Symptomatic pruritus}} {{c1::Fatigue}} {{c1::Steatorrhoea}} (greasy stools due to la…
Published	02/10/2024	LFTs for PBC ‒ {{c1::alkaline phosphatase}} is the first liver enzyme to be elevated
Published	02/10/2024	{{c1::Anti-mitochondrial}} antibodies are the most specific to {{c2::Primary Biliary Cholangitis (PBC)}} and form part of the diagnostic criteria
Published	02/10/2024	Treatment of Primary Biliary Cholangitis (PBC) via {{c1::Ursodeoxycholic acid}} to reduce the intestinal absorption of {{c2::chole…
Published	02/10/2024	Treatment of PBC via {{c1::Colestyramine}} to prevent {{c2::bile acid}} absorption in the gut and help with {{c2::pruritus}} i.e. itching
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