Notes in Module 3 - Mechanisms of Drug Action

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Published	01/07/2024	In this drug action, drugs bind to receptors in biosystems forming complexes trigger signaling pathways and cause pharmacologic effects.
Published	01/07/2024	What are the four classes of non-receptor-mediated drug actions?
Published	01/07/2024	This receptor domain contains the active site that cause conformational changes that activate the drug-receptor complex
Published	01/07/2024	This activity is a prerequisite for effecting receptor-mediated pharmacologic changes
Published	01/07/2024	This receptor domain triggers signal transductions, causing changes in the biosystem
Published	01/07/2024	What are the four classes of protein targets of RMDA?
Published	01/07/2024	Give an example of regulatory proteins
Published	01/07/2024	What does epinephrine target? How does epinephrine work?
Published	01/07/2024	Drugs may be enzyme inhibitors. How does acarbose work?
Published	01/07/2024	How does dapagliflozin, a treatment for type 2 diabetes, work?
Published	01/07/2024	How does colchicine work?
Published	01/07/2024	Drugs that affect endogenous chemicals target regulatory proteins. What are the four major types of regulatory protein targets?
Published	01/07/2024	Distinguish between ligand- and voltage-gated receptors.
Published	01/07/2024	How does lidocaine elicit anaesthesia?
Published	01/07/2024	How does nicotine elicit central nervous system stimulation?
Published	01/07/2024	How does diazepam elicit sedative, anxiolytic, and anticonvulsant effects?
Published	01/07/2024	How does insulin elicit hypoglycemic effects?
Published	01/07/2024	Salbutamol is a metabotropic/GPCR-linked drug. How does it elicit bronchodilation?
Published	01/07/2024	Drugs that activate intracellular receptors must be lipophilic. How does estrogen work?
Published	01/07/2024	What are the two major RMDA drug interactions?
Published	01/07/2024	This drug effect is achieved by binding to receptors, causing receptor inhibition
Published	01/07/2024	Antagonists counteract the effect of agonists. What are the two types of antagonist drugs?
Published	01/07/2024	Morphine is a full agonist. How does it work?
Published	01/07/2024	How does isoproterenol work?
Published	01/07/2024	Naloxone is a competitive antagonist. How does naloxone work?
Published	01/07/2024	How does atropine antagonize acetylcholine?
Published	01/07/2024	Ketamine is a negative allosteric modulator/inhibitor (i.e. a non-competitive antagonist). How does it work to induce anaesthesia?
Published	01/07/2024	Benzodiazepine is a non-competitive antagonist that causes activation instead. How does it elicit anticonvulsant effects?
Published	01/07/2024	What is acute or rapid desensitization called?
Published	01/07/2024	Salbutamol causes tachyphylaxis. How?
Published	01/07/2024	Meso-2,3-dimercaptosuccinic acid (DMSA) is a metal chelator. How does it work?
Published	01/07/2024	Antacids are alkalinizing drugs. How do they work?
Published	01/07/2024	Ammonium chloride is a urinary acidifying drug. How does it work?
Published	01/07/2024	Mannitol is an osmotic diuretic. How does it manage increased intracranial pressure?
Published	01/07/2024	Urinary diuretics act on loop of Henle and proximal convoluted tubules. How do they work?
Published	01/07/2024	There are two mechanisms of RMDA antagonists in terms of target receptors. What are those?
Published	01/07/2024	How is insulin a physiologic antagonist?
Published	01/07/2024	How is protamine a pharmacologic antagonist?
Published	01/07/2024	What are the three major novel drug mechanisms?
Published	01/07/2024	Corticoids are major anti-inflammatory drugs. How do they work?
Published	01/07/2024	Gene-based therapies use genetically modified microbes or viruses to insert genes into cells. How does genetically modified oncolytic herpes virus wor…
Published	01/07/2024	Gene-based therapies supplement what Drug modality?
Published	01/07/2024	How are stem-cell-based therapies used to treat leukemia?
Published	01/07/2024	Agonist binding results to receptor ___
Published	01/07/2024	Morphine is a full agonist. How does it elicit analgesia?
Published	01/07/2024	Isoproterenol is another agonist. How does it work?
Published	01/07/2024	Distinguish between the two types of antagonistic interactions.
Published	01/07/2024	Naloxone is a competitive antagonist. How does it work?
Published	01/07/2024	Atropine is a competitive antagonist. How does it work?
Published	01/07/2024	Ketamine is a negative allosteric modulator/inhibitor. How does it elicit anaesthesia?
Published	01/07/2024	Benzodiazepine is a negative allosteric modulator of GABA-A receptor. How does it work?
Published	01/07/2024	What is the primary determinant of receptor feedback regulation?
Published	01/07/2024	What is desensitization?
Published	01/07/2024	Drugs that cause rapid or acute desensitization trigger a phenomenon called ___
Published	01/07/2024	Salbutamol causes tachyphylaxis through the process of ___
Published	01/07/2024	How does repeated salbutamol use cause attenuation of bronchodilation?
Published	01/07/2024
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