Notes in 05IntroToANSPharma

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Status	Last Update	Fields
Published	07/30/2024	QC: Adrenal medulla secretion(1) Epinephrine(2) Norepinephrine{{c1::1 > 2}}
Published	07/30/2024	QC: number of ganglia 1) paravertebral chains 2) prevertebral chains{{c1::A}}
Published	07/30/2024	Origin of PNS: {{c1::CN 3, 7, 9, 10, S2-S4::(cranial nerves and/or nerve segments}}
Published	07/30/2024	Synthesis of ACh{{c1::Acetyl-Coa::substrate}} + {{c1::Choline::substrate}} -{{c2::Choline Acetyltransferase (ChAT)::enzyme}}-> Acetylcholine
Published	07/30/2024	Release of most NTsPropagation of Action Potential → {{c1::Voltage-gated Ca2+ Channel::Channel}} → Entry of Calcium → Calcium + {{c2::Synaptotagm…
Published	07/30/2024	Drug/s that inhibit the {{c2::choline transporter (CHT)}} is/are {{c1::hemicholinium}}
Published	07/30/2024	Drug/s that inhibit the {{c2::vesicle associated transporter (VAT)}} is/are {{c1::vesamicol}}
Published	07/30/2024	VR: Increase in Botulinum Toxin (BOTOX) → {{c1::Dec::Dec/Inc}}rease in ACh Release
Published	07/30/2024	Synthesis of {{c4::Norepinephrine}}{{c1::Tyrosine::substrate}} → {{c1::Tyrosine Hydroxylase::enzyme}} → {{c2::L-Dopa::product}} → {{c2:…
Published	07/30/2024	{{c1::Tyrosine::substrate}} → {{c1::Dopa::product}} is the rate limiting step in the synthesis of cathecolamines
Published	07/30/2024	Synthesis of {{c2::Epinephrine}}{{c2::Norepinephrine::substrate}} → {{c1::Phenylethanolamine-N-methyltransferase::enzyme}} → {{c2::Epinephri…
Published	07/30/2024	Storage of Catecholamines{{c2::Norepinephrine/Dopamine::catecholamines}} → {{c1::Vesicular Monoamine Transporter (VMAT)::transporter}} → Vesicle
Published	07/30/2024	Drug/s that inhibit the {{c2::vesicular monoamine transporter (VMAT)}} is/are {{c1::reserpine}}
Published	07/30/2024	Storage of NENE in the cleft → {{c1::Norepinephrine transporter (NET), uptake 1, or reuptake 1::transporter}} → Neuronal cytoplasm
Published	07/30/2024	VR: Increase in Tyramine → {{c1::No Effect}} in ACh Release
Published	07/30/2024	VR: Increase in Guanethidine → {{c1::Decrease}} in NE {{c2::Release}}
Published	07/30/2024	Drug/s that inhibits MAO activity, promotes release and used to treat ADHD is/are {{c1::amphetamine}}
Published	07/30/2024	VR: Increase in Ephedrine → {{c1::Increase}} in NE {{c2::Release}}
Published	07/30/2024	VR: Increase in Cheese Intake → {{c1::Increase}} in NE Release because of {{c2::Tyramine::compound}}
Published	07/30/2024	Drug/s that inhibit {{c2::Norepinephrine transporter (NET)}} is/are {{c1::Cocaine and tricyclic antidepressants}}
Published	07/30/2024	VR: Increase in Antidepressant use → {{c1::Decrease}} in NE Reuptake
Published	07/30/2024	QC: GCPR(1) Muscarinic Receptors(2) Nicotinic Receptors{{c1::1 > 2}}
Published	07/30/2024	QC: Response to NE(1) Muscarinic Receptors(2) Nicotinic Receptors{{c1::1 = 2}}
Published	07/30/2024	Muscarinic ReceptorsReceptor: {{c1::M1}}Found in: {{c2::Secretory glands, Nerve Endings}}Postreceptor mechanism: {{c2::↑ IP3-DAG}}
Published	07/30/2024	Muscarinic ReceptorsReceptor: {{c1::M2}}Mainly found in: {{c2::Heart, Smooth Muscle}}Postreceptor mechanism: {{c2::↓ cAMP, K+ channel a…
Published	07/30/2024	Muscarinic ReceptorsReceptor: {{c1::M3}}Mainly found in: {{c2::Exocrine Glands, Smooth Muscle Bladder, Endothelium, ciliary muscle}}Postrece…
Published	07/30/2024	Muscarinic ReceptorsReceptor: {{c1::M4}}Mainly found in: {{c2::autonomic ganglia}}Postreceptor mechanism: {{c2::↓ cAMP}}
Published	07/30/2024	Muscarinic ReceptorsReceptor: {{c1::M5}}Mainly found in: {{c2::Cerebral Vessels, sphincter muscle of pupil, in esophagus and parotid gland}}…
Published	07/30/2024	Nicotinic ReceptorsReceptor: {{c1::Nn or N2}}Mainly found in: {{c2::Neuronal ANS Ganglia}}Postreceptor mechanism: {{c2::Na+, K+ channel…
Published	07/30/2024	Nicotinic ReceptorsReceptor: {{c1::Nm or N1}}Mainly found in: {{c2::Skeletal Muscle (at the Neuromuscular Endplate)}}Postreceptor mechanism:…
Published	07/30/2024	Alpha ReceptorsReceptor: {{c1::α1}}Mainly found in: {{c2::Smooth muscles (BV, GIT, GUT,), piloerector, radial muscle, apocrine sweat glands}…
Published	07/30/2024	Alpha ReceptorsReceptor: {{c1::α2}}Mainly found in: {{c2::Presynaptic Adrenergic Terminals, Platelets, Lipocytes, Smooth Muscles}}Postrecept…
Published	07/30/2024	Beta ReceptorsReceptor: {{c1::β1}}Mainly found in: {{c2::Heart, Ciliary Body, Brain, Kidney}}Postreceptor mechanism: {{c2::↑ cAMP}…
Published	07/30/2024	Beta ReceptorsReceptor: {{c1::β2}}Mainly found in: {{c2::Lungs, Uterus, Liver, Pancreas}}Postreceptor mechanism: {{c2::↑ cAMP}}
Published	07/30/2024	Beta ReceptorsReceptor: {{c1::β3}}Mainly found in: {{c2::Lipocytes, Bladder}}Postreceptor mechanism: {{c2::↑ cAMP}}
Published	07/30/2024	Dopamine ReceptorsReceptor: {{c1::D1 & D5::(subtype)}}Mainly found in: {{c2::Renal Vascular Bed}}
Published	07/30/2024	Dopamine ReceptorsReceptor: {{c1::D2::(subtype)}}Mainly found in: {{c2::Brain, Smooth Muscle, Presynaptic Nerve Terminals}}
Published	07/30/2024	Dopamine ReceptorsReceptor: {{c1::D3::(subtype)}}Mainly found in: {{c2::Brain}}
Published	07/30/2024	Dopamine ReceptorsReceptor: {{c1::D4::(subtype)}}Mainly found in: {{c2::Brain & Cardiovascular System}}
Published	07/30/2024	Nerve fibers that do not show characteristics of either cholinergic or adrenergic fibers are known as {{c1::Nonadrenergic Noncholinergic Neu…
Published	07/30/2024	QC: Ergotropic(1) PNS(2) SNS{{c1::1 < 2}}
Published	07/30/2024	QC: Trophotropic(1) PNS(2) SNS{{c1::1 > 2}}
Published	07/30/2024	VR: Increase in α2 activation → {{c1::Increase}} in Negative Feedback Control
Published	07/30/2024	AmphetamineMechanism of Action: {{c1::Promotes release of NE and inhibits MAO}}
Published	07/30/2024	PhentoalamineMechanism of Action: {{c1::Alpha Blocker (a-Antagonist)}}
Published	07/30/2024	IsoproterenolMechanism of Action: {{c1::Adenylyl Cyclase Agonist}}
Published	07/30/2024	PropanololMechanism of Action: {{c1::Non-selective beta blocker (b-Antagonist))}}
Published	07/30/2024	TranylcypromineMechanism of Action: {{c1::MAO Inhibitor}}
Published	07/30/2024	MAO inhibitors --> {{c1::inhibits::effect}} metabolism of NE
Published	07/30/2024	VR:1) Chlonidin 2) Vasodilation{{c1::A}}
Published	07/30/2024	{{c1::Choline::substrate}} for ACh synthesis is transported from the ECF through a {{c1::sodium-dependent choline cotransporter (CHT)}}
Published	07/30/2024	Storage of AChAcetylcholine → {{c1::Vesicle-Associated Transporter (VAT)::transporter}} → Vesicles
Published	07/30/2024	ACh is {{c1::recycled::excreted/recycled}}
Published	07/30/2024	ACh is metabolized by acetylcholinesterase into {{c1::choline and acetate}}
Published	07/30/2024	Drug/s that inhibit {{c2::tyrosine hydroxylase}} is/are {{c1::metyrosine}}
Published	07/30/2024	[QC] 1. Dopamine 2. NE 3. E{{c1::2 > 3 > 1}}
Published	07/30/2024	NE binds to {{c1::alpha, beta, and dopamine::adrenergic}} receptors
Published	07/30/2024	Cathecolamines are metabolized by {{c2::monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT)}} and are excreted in the urine (VMA)
Status	Last Update	Fields