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Notes in
a. Amino Acids
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Status
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Published
07/28/2024
A
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R
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N
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D
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C
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E
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Q
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G
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H
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I
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L
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K
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M
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F
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P
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S
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T
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W
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Y
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V
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Ala
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Arg
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Asn
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Asp
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Cys
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Glu
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Gln
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Gly
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His
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Ile
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Leu
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Lys
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Met
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Phe
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Pro
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Ser
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Thr
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Trp
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Tyr
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Val
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Nonpolar, nonaromatic (7)
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Aromatic side chains (3)
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Polar side chains (5)
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Acidic negatively charged side chains
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Basic positively charged side chains (3)
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Hydrophobic amino acids (5)
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Hydrophilic amino acids (7)
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if pH < pKa, amino acid will be...
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if pH > pKa, amino acid will be...
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Protons are typically gained under _______ conditions.
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Protons are typically lost under _______ conditions.
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What is the pKa of an amino acid?
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When pH ~= pKa, the solution acts as a...
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• C alpha is chiral, with the exception of {{c1::glycine}}
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Amino acids with nonpolar side chains are typically found in {{c1::protein interiors}}
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Charged amino acids are often found on {{c1::protein surfaces}} & at {{c1::enzyme active sites}}
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Henderson-Hasselbalch Equation
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Definition of pKa
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At the pKa, the buffering capacity is {{c1::greatest}} (practical range usually pKa±1 pH unit)
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The pI is the pH at which the net charge on the molecule is {{c1::zero}} (isoelectric point)
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Terminal alpha-carboxyl group pKa:
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Aspartic acid/Glutamic acid pKa:
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Histidine pKa:
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Terminal alpha-amino group pKa:
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Cysteine pKa:
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Tyrosine pKa:
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Lysine pKa:
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Arginine pKa:
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All amino acids (except glycine) derived from proteins have the {{c1::L}} configuration
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Explaine R/S system of Nomenclature
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All of the L-amino acids except {{c1::cysteine}} are (S)-amino acids
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No modifications on {{c1::Leu}}, {{c1::Ile}}, {{c1::Val}}, {{c1::Ala}}, or {{c1::Phe}} side chains are known
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Essential Amino Acids (Hint: PVT TIM HaLL = private Tim Hall)
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