Notes in Dyslipidemia

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Published	10/16/2023	The main side effect of fish oils is that they {{c1::smell stinky}}
Published	10/16/2023	{{c2::Orlistat}} is an inhibitor of gastric and pancreatic {{c1::lipase}}, thus leading to decreased breakdown and absorption of dietary {{c1::fats}}
Published	10/16/2023	After being absorbed from the GI tract, free cholesterol is packaged into a(n) {{c1::chylomicron}} as cholesterol ester
Published	10/16/2023	{{c1::Chylomicrons}} deliver triglycerides from the intestine to peripheral tissues
Published	10/16/2023	{{c1::VLDLs}} deliver triglycerides directly from the liver to peripheral tissues
Published	10/16/2023	{{c1::LDLs}} are the main source of cholesterol delivery to peripheral tissues in the body
Published	10/16/2023	{{c1::Ezetimibe}} is a lipid-lowering agent that blocks absorption of {{c2::cholesterol}} at the small intestinal brush border
Published	10/16/2023	{{c1::Fibrates}} upregulate the enzyme {{c2::lipoprotein lipase (LPL)}} by activating {{c3::PPAR-α}}
Published	10/16/2023	{{c1::Fish oil}}, a supplement high in {{c2::omega-3 fatty}} acids, may be used to lower serum {{c3::triglyceride}} levels
Published	10/16/2023	Fibrates mildly increase the synthesis of {{c1::HDL::lipoprotein}} via upregulation of PPAR-α
Published	10/16/2023	Macrophages bloated with cholesterol eventually form {{c1::foam}} cells within the subendothelium
Published	10/16/2023	{{c1::Praluent::drug}} is monoclonal antibodies against {{c2::PCSK9}}, a protein that normally {{c3::degrades LDL receptors}}
Published	10/16/2023	Dyslipidemia1) elevation of plasma {{c1::cholesterol}}, {{c1::triglycerides}} (TGs), or bothor 2) a low {{c2::high-density lipoprotein …
Published	10/16/2023	Total Cholesterol should be approximately less than {{c1::200}} mg/dl. Out of the {{c1::200}}:LDL: < {{c2::100}} mg/dlHDL: > {{c2::60}} mg/dlTri…
Published	10/16/2023	Lipids from diet, supplies fatty acids after meals{{c1::Chylomicrons::Lipid Particle}}
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Published	10/16/2023	HDL delivers {{c1::cholesterol}} to the {{c2::liver}} for elimination
Published	10/16/2023	Half life of LDL is much {{c1::longer::longer/shorter}} than that of HDL/Chylomicrons
Published	10/16/2023	Familial hypercholesterolemia/Common Genetic Causes{{c1::APOB – Apolipoprotein B}} – Major protein in LDL, VLDL and Chylomicrons.Changes in the {{c2::…
Published	10/16/2023	{{c1::Statins}} - Inhibit cholesterol synthesis in liver; also increases LDL uptake by liver.
Published	10/16/2023	{{c1::Bile acid chelators}} - bind and eliminate bile acids in GI tract
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