Notes in Protein Folding & Misfolding

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Published	09/07/2023	The burial of {{c1::hydrophobic}} residues is generally thought to be the primary driving force of protein folding
Published	09/07/2023	{{c1::Hydrogen}} bonds are thought to provide the specificity of structural interactions instead of the driving force
Published	09/07/2023	{{c1::Anfinsen}}’s hypothesis was that proteins sample all possible conformations and then choose the one with the lowest energy
Published	09/07/2023	{{c1::levinthal}}'s paradox is that there are too many possible conformations for a protein to try before finding the lowest energy one to allow prote…
Published	09/07/2023	this funnel shows {{c1::partially folded intermediates}} that may trap proteins in a certain folded form
Published	09/07/2023	The role of {{c1::chaperones}} is to provide a dynamic polarity environment for monomeric folding and to prevent association of partially folded in…
Published	09/07/2023	{{c1::Partially folded intermediate}} fates include: folding to the native conformation, unfolding to the denatured conformation, folding to a trap…
Published	09/07/2023	Protein {{c1::aggregation}} is the main reason why protein misfolding is pathogenic
Published	09/07/2023	{{c1::aggregation}} of misfolded proteins can lead to loss of function or gain of toxic activity
Published	09/07/2023	{{c1::genetic}} (spontaneous/genetic) forms of protein misfolding disease tend to strike younger people and are usually more severe than the other …
Published	09/07/2023	{{c1::amyloid}} was first identified as a component of plaques in the brains of Alzheimer’s patients and can form amorphous aggregates or profibril…
Published	09/07/2023	{{c1::Prion}} diseases such as transmissible spongiform encephalopathies (Creutzfeldt- Jakob Disease) occur when the disease form of the prion prot…
Published	09/07/2023	In the case of prion protein, the conformational change increases the amount of {{c1::beta}} strand which contributes to the aggregation of the pro…
Published	09/07/2023	The polyglutamine expansion diseases such as {{c1::Huntington’s}} disease occur when trinucleotide repeats expand in the genome, which results in t…
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