Notes in 11. Rifabutin and 12. Rifapentine

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Published	10/21/2024	The drug {{c1::Rifabutin}} is used in place of rifampin for the treatment of tuberculosis in patients with HIV infections who are receiving ART with:{…
Published	10/21/2024	Rifabutin has significant activity against: {{c1::M. tuberculosis}}{{c1::MAC}}{{c1::Mycobacterium fortuitum}}
Published	10/21/2024	Rifabutin has an activity similar to that of {{c1::rifampin}}, and cross-resistance with it is {{c1::virtually complete}}
Published	10/21/2024	Adverse effects associated with rifabutin are similar to rifampin, such as:{{c1::hepatotoxicity}} or {{c1::rash}}It can also cause:{{c1::Leukopenia}}{…
Published	10/21/2024	Compared to rifampin, rifabutin is {{c1::less potent}} but has more {{c1::tolerable side effects}}
Published	10/21/2024	Rifabutin requires {{c1::dose adjustment}} (for renal adjustment) and is {{c1::not available}} in the Philippines
Published	10/21/2024	Rifampin is more {{c1::potent}}, and a small dose has a therapeutic effect, but it comes with {{c1::side effects}}
Published	10/21/2024	{{c1::Rifapentine}} is another analog of rifampin
Published	10/21/2024	The mechanism of action of rifapentine is as a {{c1::bacterial RNA polymerase inhibitor}}
Published	10/21/2024	There is {{c1::complete cross-resistance}} between rifampin and rifapentine
Published	10/21/2024	Rifapentine is combined with {{c1::isoniazid}} in a treatment known as 3HP. Both medications are typically given at a dose of {{c1::900 mg}} once a we…
Published	10/21/2024	Rifapentine combined with isoniazid dosed daily for {{c1::1 month}} has shown efficacy against LTBI in patients with {{c1::HIV}}
Published	10/21/2024	Adverse effects of rifapentine include similar rates of {{c1::hepatotoxicity}} or {{c1::rash}} compared to rifampin and can also cause:{{c1::Leukopeni…
Published	10/21/2024	Rifapentine is not given to active TB patients with HIV due to a {{c1::high relapse or decreased cure rate}} but is an effective {{c1::prophylaxis}}
Published	10/21/2024	Rifampin or rifampicin is more {{c1::potent}} than rifapentine
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