Notes in Laboratory Diagnostics

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Published	09/05/2023	Laboratory tests can lead to or confirm {{c1::diagnoses}} and aid in choosing appropriate therapy→ challenge is to provide accurate, clinically releva…
Published	09/05/2023	Culture-based detection- bacterial culture depends on {{c1::growth}} of organisms on various culture media: selective, differential, enriched*each par…
Published	09/07/2023	Culture-based detection: {{c11::bloodstream}} infection- {{c2::sepsis}}: infection of the blood- detect of bacterial pathogens via {{c3::inc…
Published	09/05/2023	Principles for Quality Specimen Collection and Transport- Use sterile technique to minimize contamination- Collect as {{c1::close}} to site of in…
Published	09/05/2023	Culture-based detection: {{c1::respiratory tract}} infections*side note: most respiratory tract infections have {{c2::viral}} causes- laboratory …
Published	09/05/2023	Culture-based detection: {{c1::nervous system}} infections*bacterial meningitis has significant morbidity and mortality- {{c2::Cerebrospinal flui…
Published	09/05/2023	Culture-based detection: {{c1::gastrointestinal}} infections*most common manifestation of gastrointestinal (GI) infection in pediatrics is acute {{c2:…
Published	09/05/2023	NON-culture-based detection: microscopy- direct microscopic observation of the specimen is a simple yet reliable technique for demonstrating presence …
Published	09/05/2023	NON-culture-based detection: mass spectrometry- {{c1::matrix-assisted laser desorption/ionization time-of-flight mass spectrometry}} (MALDI-TOF-MS) is…
Published	09/05/2023	NON-culture-based detection: molecule diagnostic techniques- {{c1::Nucleic acid amplification tests (NAATs)}} detect bacterial nucleic acid from …
Published	09/05/2023	NON-culture-based detection: {{c1::sequence}}-based technologies- used to improve speed and accuracy of identification of organisms that are diff…
Published	09/05/2023	SARS-CoV2 = {{c1::severe acute respiratory syndrome coronavirus 2}}- signs and symptoms of coronavirus disease overlaps with those of other …
Published	09/05/2023	SARS-CoV2: speciment selectrion, collection, transport- collecting appropriate specimen at right time and transporting it to laboratory under proper c…
Published	10/05/2023	SARS-CoV2: nucleic acid detection*RT-PCR is a type of NAAT- current recommended modality for diagnosis: {{c1::nucleic acid amplification test}} (…
Published	09/05/2023	SARS-CoV2: viral antigen detection- {{c1::lateral-flow}} immunoassays for qualitative detection of {{c2::nucleocapsid}} protein antigen directly from …
Published	09/05/2023	SARS-CoV2: antibody detection- tests used to detect anti–SARS-CoV-2 antibodies in blood and saliva specimens are used to identify patients currently o…
Published	09/05/2023	Testing For Patients with Multisystem Inflammatory Syndrome*COVID-19 in children often has a relatively {{c1::mild}} presentation- Starting in April 2…
Published	09/08/2023	Pulmonary {{c1::infiltrates}} are substances that are denser than air and are due to {{c2::fluid}}→ edema→ purulent fluid (infection)→ blood (trauma o…
Published	09/08/2023	{{c1::nucleic acid amplification test/PCR}} is the most sensitive test for viral pathogens *viral culture and rapid antigen tests are 2nd best
Published	09/08/2023	infectious disease testing→ methods can be amplified or unamplifiedunamplified- rapid antigen test ({{c2::antibody}} on test strip complementary to ta…
Published	09/08/2023	test performance vs. diagnosistest performance characteristics- {{c1::sensitivity}}: ability of test to detect virus in patient that has said virus&nb…
Published	09/08/2023	an ideal sputum culture should have...*should be from {{c1::lower}} respiratory tract- abundant {{c2::leukocytes}} (alveolar macrophages and neutrophi…
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