Notes in PHARM 111-03

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Status	Last Update	Fields
Published	09/19/2023	What are Ionic ATPase's?found where?{{c1::in all cells}}are responsible for{{c1::maintaining ionic gradients across membranes}}use what for energy?{{c…
Published	09/19/2023	Na+-K+ ATPaseHow many Na+ are extruded and how many K+ are brought in?Electrogenic? If so, how is energy generated and to what degree?
Published	09/20/2023	Na+-K+ ATPaseWhat modulates the activity of Na+-K+ ATPase?
Published	09/19/2023	How does the structure of Na+-K+ ATPase differ from a channel?
Published	09/20/2023	Na+-K+ ATPase cycle (know this)E1 = enzyme in conformation 1binds ATP, {{c1::then Na+ binds into the first port through the cavity E1-ATP}}after, the …
Published	09/20/2023	V-ATPase's are:a large family of proteins that {{c1::extrude H+ using ATP as a source of energy}}another type located in {{c2::the mitochondria}}"work…
Published	09/19/2023	V-ATPase's are important for{{c1::balancing pH in urine}}{{c2::regulating the amount of neurotransmitter for action potentials}}{{c3::keeping alveoli …
Published	09/20/2023	V-ATPase's have a variety of targets at two levels:{{c1::at the organ levelat the subcellular level}}
Published	09/19/2023	What does SERCA Stand for?
Published	09/20/2023	Re: Ca2+-ATPase The 3 types of Ca Pumps are{{c1::Plasma membrane Ca2+-ATPase (PMCA)Endoplasmic Reticulum Ca2+-ATPase (ERCA?)Sarco(muscle)/En…
Published	09/20/2023	SERCA{{c1::Intracellular "Ca-pump"}} ubiqutously expressedkeeps {{c1::intracellular Ca2+ }}concentration low3 genes encode for SERCA, namely {{c2…
Published	09/20/2023	SERCA{{c1::The H+ released from SERCA doesn't make the molecule itself acidic}} because the {{c2::turnover is low}}
Published	09/20/2023	Na+-Ca2+ ExchangerCa2+ {{c1::extruder}} located in the plasma membrane that {{c1::uses the Na+ electrochemical gradient}}The stoichiome…
Published	09/19/2023	NCX cycle (skipped over really)will put IO card
Published	09/20/2023	Monoamine neurotransmitter transportersfamily of membrane proteins that transport (4 things) {{c1::norepinephrine, epinephrine, dopamine and 5-HT}} in…
Published	09/20/2023	Targeting 5-HT transporters to boost synaptic activityInhibiting {{c1::the transport of 5-HT from the cleft to the presynaptic terminal}} {{c2::increa…
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