Notes in LE018 Cancer Genetics

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Published	10/16/2024	Why is cancer inevitable in multicellular organisms and not in unicellular organisms?
Published	10/16/2024	programs to control cell divisin act as safeguards in maintainging cell integrity. What are the mechanisms to prevent caner from happening?
Published	10/16/2024	mutations in which three types of genes is involved in development of cancer. Define them
Published	10/16/2024	Tumorigenesis is a result of {{c1:: DNA damage}}, leading to genomic instability, in the absence of the function of {{c1::caretaker genes}}.
Published	10/16/2024	cancer is a {{c1::multifactorial}} disease and thus many different genetic factors and environemnetal factors lead to the same type of cancer. However…
Published	10/16/2024	What are the hallmarks of cancer?
Published	10/16/2024	Two hit hypothesis in cancer.
Published	10/16/2024	What is combinatorial complexity in terms of cancer?
Published	10/16/2024	What are the two types changes from mutations takes the proto-oncogene to an oncogene?
Published	10/16/2024	How are oncogenes activated?{{c1:: Amplifications}}: increase in gene copy within a single chromosome.{{c1:: Translocations resulting in fusion effect…
Published	10/16/2024	How does the cell respond to DNA damage?
Published	10/16/2024	What is the link between cancer and DNA methylations?
Published	10/16/2024	How are microRNAs used to treat cancer?
Published	10/16/2024	What is clonal complexity in tumors? How do founder mutations and cooperating driver mutations contribute to this?
Published	10/16/2024	Why are cancer/tumor samples so hard to detect sometimes?
Published	10/16/2024	{{c1::70-80}}% of all cancers are sporadic. {{c1::15-20}}% family clustering (higher than if unrelated without obviors Mednaelian inheritance). {{c1::…
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