Notes in E.2.Polycythemia vera

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Published	10/21/2024	Characterized by increased marrow production of red cells, granulocytes, and platelets panmyelosis
Published	10/21/2024	In polycythemia vera, it is the increase in ____ that is responsible for most of the clinical symptoms
Published	10/21/2024	What is the pathogenesis for polycythemia vera?
Published	10/21/2024	Is the serum erythropoietin levels in polycythemia vera high or low?
Published	10/21/2024	What can be observed in the bone marrow morphology in polycythemia vera?
Published	10/21/2024	What can be observed in the peripheral blood in polycythemia vera?
Published	10/21/2024	What happens during the spent phase where there is extensive bone marrow fibrosis in polycythemia vera?
Published	10/21/2024	Patients in PCV look both:
Published	10/21/2024	What are the common symptoms of PCV
Published	10/21/2024	What are other more serious symptoms of PCV
Published	10/21/2024	What are the laboratory findings in PCV
Published	10/21/2024	What could be the treatment for PCV?
Published	10/21/2024	This is largely due to extramedullary hematopoiesis occurring in the setting of advanced marrow myelofibrosis
Published	10/21/2024	Associated with diverse mutations that increase JAK-STAT signaling and mimic constitutive growth factor receptor signaling
Published	10/21/2024	Mutations in ____, ___ and ___ can cause the JAK-STAT signaling pathway to remain constantly active
Published	10/21/2024	Manifests clinically with elevated platelet counts
Published	10/21/2024	How is essential thrombocytosis separated from PCV and primary myelofibrosis?
Published	10/21/2024	In the pathogenesis of essential thrombocytosis, the constitutive JAK2 or MPL signaling renders the progenitors of platelets ____ and therefore leads …
Published	10/21/2024	What can be observed in the bone marrow morphology in essential thrombocytosis?
Published	10/21/2024	What can be observed in the peripheral blood in essential thrombocytosis?
Published	10/21/2024	What are the clinical manifestations in essential thrombocytosis?
Published	10/21/2024	Caused by occlusion of small arterioles by platelet aggregates which may also be seen in polycythemia vera
Published	10/21/2024	What is the hallmark of primary myelofibrosis
Published	10/21/2024	Approximately 90% of cases of primary myelofibrosis have activating mutations of __, ___ and __
Published	10/21/2024	What is the chief pathologic feature of primary myelofibrosis?
Published	10/21/2024	What are the factors synthesized by megakaryocytes?
Published	10/21/2024	Both of these are fibroblast mitogens
Published	10/21/2024	____ promotes collagen deposition and causes angiogenesis
Published	10/21/2024	What can be observed in the bone marrow morphology in primary myelofibrosis?
Published	10/21/2024	What can be observed in the peripheral blood in primary myelofibrosis?
Published	10/21/2024	How do you diagnose essential thrombocytosis?
Published	10/21/2024	A spectrum of clonal proliferations of a special type of immature dendritic cell called the Langerhans cell
Published	10/21/2024	What is the pathogenesis of Langerhans Cell Histiocytosis?
Published	10/21/2024	What can be seen in the morphology of Langerhans Cell Histiocytosis?
Published	10/21/2024	This display abundant cytoplasm that often appears vacuolated. Their nuclei are vesicular and show linear grooves or folds, giving them a unique appea…
Published	10/21/2024	Present in the cytoplasm of Langerhans cells Have a characteristic “tennis racket-like” appearance due to the pentalaminar tubules with a dilated term…
Published	10/21/2024	What are the markers in Langerhans Cell Histiocytosis?
Published	10/21/2024	What are the clinical features in Langerhans Cell Histiocytosis?
Published	10/21/2024	Other term for Letterer-Siwe Disease
Published	10/21/2024	Usually occurs before 2 years of age Development of cutaneous lesions resembling a seborrheic eruption Most of those affected have: − Concurrent hepat…
Published	10/21/2024	2 types of Eosinophilic Granuloma
Published	10/21/2024	Characterized by proliferations of Langerhans cells admixed with variable numbers of eosinophils, lymphocytes, plasma cells, and neutrophils
Published	10/21/2024	Characteristics of Hand-Schüller-Christian triad
Published	10/21/2024	Often seen in adult smokers which may regress spontaneously upon cessation of smoking
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