Notes in 12 Cholinesterase Inhibitors& Other PharmacologicalAntagonists to NeuromuscularBlocking Agents

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Published	12/13/2023	Cholinergic receptors are subdivided into two major groups based on their reaction to the alkaloids {{c1::muscarine}} and {{c1::nicotine}}
Published	12/13/2023	{{c2::Nicotinic}} cholinergic receptors are present in the {{c1::autonomic ganglia}} and {{c1::skeletal muscle}}
Published	12/13/2023	{{c2::Muscarine}} activates the {{c1::post}}ganglionic neurons of the {{c1::parasympathetic}} nervous system.
Published	12/13/2023	{{c2::Cholinesterase inhibitors::drug class}} indirectly increase the amount of {{c1::acetylcholine}} available to compete with a nondepolarizing…
Published	12/13/2023	{{c1::Cholinesterase inhibitors}} inactivate {{c2::acetylcholinesterase}}, increasing the amount of acetylcholine available at the neuromuscular junct…
Published	12/13/2023	Muscarinic side effects of cholinesterase inhibitors on the cardiovascular system results in {{c1::bradyarrhhythmias}} leading to {{c2::sinus arrest}}…
Published	12/13/2023	Muscarinic side effects of cholinesterase inhibitors on the respiratory system results in broncho{{c1::spasm}} and {{c1::increased}} se…
Published	12/13/2023	Muscarinic side effects of cholinesterase inhibitors on the gastrointestinal system results in {{c1::intestinal spasm}} and {…
Published	12/13/2023	Muscarinic side effects of cholinesterase inhibitors on the genitourinary system results in increased {{c1::bladder tone}}
Published	12/13/2023	Muscarinic side effects of cholinesterase inhibitors on the opthomalogical system results in {{c1::pupillary constriction}}
Published	12/13/2023	Edrophonium, neostigmine, & pyridostigmine are {{c1::quaternary}} amines that do not cross the blood brain barrier.
Published	12/13/2023	Muscarinic side effects of physostigmine on the central nervous system results in {{c1::diffuse excitation}}
Published	12/13/2023	The time to reverse neuromuscular blockade is directly related to the {{c1::depth}} of the block.
Published	12/13/2023	The muscarinic side effects of neostigmine are minimized by prior or concomitant administration of an {{c1::anticholinergic}} drug.
Published	12/13/2023	Glycopyrolate is associated with {{c1::LESS}} tachycardia when compared to atropine
Published	12/13/2023	{{c1::Pyridostigmine}} and {{c1::neostigmine}} covalently bind to {{c2::acetylcholinesterase}}.
Published	12/13/2023	{{c1::Glycopyrrolate}} or {{c1::atropine}} must be administered with most cholinesterase inhibitors to prevent {{c2::bradycardia}}.
Published	12/13/2023	{{c2::Physostigmine}} is a {{c3::tertiary}} amine, making it the only cholinesterase inhibitor that freely passes the {{c1::blood–brain barrier (…
Published	12/13/2023	Edrophonium has the {{c1::fastest::slowest/fastest}} onset of action and the {{c1::shortest::shortest/longest}} duration of effect of any of the choli…
Published	12/13/2023	Sugammadex is eliminated unchaged via the {{c1::kidneys}}
Published	12/13/2023	Sugammadex may impair the contraceptive effect of patients using {{c1::hormonal}} contraceptives due to its affinity for compounds with {{c2::steroida…
Published	12/13/2023	Sugammadex is not effective in reversing the {{c1::benzylisoquinoline}} class of nondepolarizing neuromuscular blockers.
Published	12/13/2023	The reversal dose for neostigmine is {{c1::0.04}} - {{c1::0.08}} mg/kg, with a maximum dose of {{c2::5}} mg.
Published	12/13/2023	The most serious reaction to sugammadex is {{c1::anaphylaxis}}.
Published	12/13/2023	When edrophonium is used to reverse neuromuscular blockade, the anticholinergic of choice is {{c1::atropine}} with a dose of {{c1::15 mcg}} per m…
Published	12/13/2023	When neostigmine is used to reverse neuromuscular blockade, the anticholinergic of choice is {{c1::glycopyrrolate}} with a dose of {{c1::0.2 mg}}…
Published	12/13/2023	{{c3::Choline acetyltransferase}} catalyzes the conversion of {{c2::acetyl CoA}} and {{c2::choline}} to {{c1::acetylcholine}}.
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