Notes in 08AdrenoceptorAgonists

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Published	07/30/2024	2 Indirect-acting adrenergic drugs ({{c2::Releasers::What subclass?}}):{{c1::- Tyramine- Amphetamine- Bonus: Methamphetamine::Bonus if you c…
Published	07/30/2024	2 Indirect-acting adrenergic drugs ({{c2::Reuptake inhibitors::What subclass?}}):{{c1::- Cocaine- Tricyclic antidepressants- Bonus: Atomoxetine::…
Published	07/30/2024	VR: Increase in {{c1::D-1}} receptor stimulation → increase renal blood vessel diameter
Published	07/30/2024	VR: Increase in {{c1::B-3}} receptor stimulation → decrease detrusor muscle contraction
Published	07/30/2024	VR: Increase in {{c1::A-1}} receptor stimulation → increase pilomotor smooth muscle contraction
Published	07/30/2024	Absence of one or both -OH group on a phenylethylamine benzene ring offers {{c1::resistance to COMT and lipid solubility}}. Examples ar…
Published	07/30/2024	Increasing the size of alkyl substituents on the amino group of phenylethylamine...increases {{c1::beta}} receptor activitydecreases {{c1::a…
Published	07/30/2024	Methyl substitution on NE on the amino group of phenylethylamine increases {{c1::beta-2}} receptor activity
Published	07/30/2024	Adding a methyl group on the alpha carbon of phenylethylamine offers {{c1::resistance to MAO and lipid solubility}}. Examples are {{c2::amph…
Published	07/30/2024	QC: Addition of methyl group on alpha carbon on Phenylethylamine(1) Direct-acting sympathomimetic(2) Indirect-acting sympathomimetic{{c1::1&…
Published	07/30/2024	Adrenergic Drug/s that are {{c2::A1}} selective is/are {{c1::Phenylephrine, Methoxamine, and Midodrine}} and are used as {{c3::decongestants (neo…
Published	07/30/2024	Adrenergic Drug/s that are {{c2::A2}} selective is/are {{c1::Clonidine, Methyldopa (Methylnorepinephrine), Dexdemetonidine, and&nb…
Published	07/30/2024	Adrenergic Drug/s that are {{c2::non}} selective is/are {{c1::NE, E, and ephedrine}}In hypotension, use {{c1::NE}}In anaphylaxis, use {{c1::E}}In…
Published	07/30/2024	Adrenergic Drug/s that are {{c2::B1}} selective is/are {{c1::(+) Dobutamine}}bonus* which isomer
Published	07/30/2024	Adrenergic Drug/s that are {{c2::beta (B1 = B2)}} selective is/are {{c1::Isoproterenol}}
Published	07/30/2024	Adrenergic Drug/s that are {{c2::B2}} selective is/are...{{c1::Albuterol (new name of sabutamol), Terbutaline, Metaproterenol, Ritodrin…
Published	07/30/2024	Dopamine agonistsQC: Dopamine affinity(1) Alpha(2) Beta{{c1::1<2}}
Published	07/30/2024	Fenoldopam is selective for {{c1::D-1}} receptorsBonus: {{c2::Levodopa is another dopamine agonist::Name another dopamine agonist drug}}
Published	07/30/2024	VR: Alpha 2 Receptor activation→ {{c1::increase}} vascular bed constriction (when given locally, rapid IV, or high doses)
Published	07/30/2024	VR: Alpha 2 Receptor activation→ {{c1::decrease}} blood pressure (when given systemically)
Published	07/30/2024	VR: Beta-2 receptor activation→ {{c1::decrease}} peripheral resistance (in certain vascular beds)
Published	07/30/2024	VR: D-1 receptor activation→ {{c1::decrease}} peripheral resistance (when given at low doses)
Published	07/30/2024	VR: D-1 receptor activation → {{c1::increase}} peripheral resistance (when given at higher rates of infusion)
Published	07/30/2024	VR: D-1 receptor activation→ {{c1::increase}} natriuresis
Published	07/30/2024	VR: 1. Beta agonist 2. Glaucoma{{c1::C}}
Published	07/30/2024	VR: 1. Alpha agonists 2. intraocular pressure{{c1::B}}
Published	07/30/2024	VR: 1. Symphathomimetics 2. Eye accomodation{{c1::C}}
Published	07/30/2024	VR: Alpha-1 receptors→ {{c1::decrease}} bladder contraction and sphincter relaxation
Published	07/30/2024	VR: Beta-2 agonist→ {{c1::increase}} uterine relaxation
Published	07/30/2024	QC: Adrenoceptor Stimulation(1) Apocrine sweat glands(2) Eccrine sweat glands{{c1::1>2}}
Published	07/30/2024	VR: Beta-2 receptors→ {{c1::decrease}} extracellular potassium
Published	07/30/2024	VR: {{c1::Beta-2}} receptors→ increase insulin secretion
Published	07/30/2024	VR: {{c1::Alpha 2}} receptors→ decrease insulin secretion
Published	07/30/2024	VR: {{c1::Beta-1}} receptors→ increase renin secretion
Published	07/30/2024	VR: {{c1::Alpha 2}} receptors→ decrease renin secretion
Published	07/30/2024	QC: CNS stimulant effects(1) Norepinephrine(2) Amphetamine{{c1::1<2}}
Published	07/30/2024	Adrenergic Drug/s that is {{c2::A1}} selective and used as a mydriatic agent for examination and for conjunctival itching is/are {{c1::Phenylephr…
Published	07/30/2024	Adrenergic Drug/s that is {{c2::A1}} selective and used for (Chronic) orthostatic hypotension is/are {{c1::Midodrine}}
Published	07/30/2024	Adrenergic Drug/s that is {{c2::A2}} selective and used for sedation is/are {{c1::Dexmedetomidine}}
Published	07/30/2024	Beta Selective AgonistsDobutamine ({{c1::+::+/-}}) isomer is a potent β1 agonist (inc. HR)
Published	07/30/2024	Beta Selective AgonistsDobutamine ({{c1::-::+/-}}) isomer is a potent α1 agonist (cause significant vasoconstriction)
Published	07/30/2024	Indirect-Acting SympathomimeticsQC: Enters CNS readily to produce stimulant effects on mood and alertness(1) Ephedrine(2) Amphetamine{{c1::1<2}}
Published	07/30/2024	QC: Methamphetamine(1) Central effects(2) Peripheral effects{{c1::1>2}}
Published	07/30/2024	Indirect-acting SympathomimeticsLocal anesthetic with a peripheral sympathomimetic action and vaso{{c2::constrictive}} effects- {{c1::Cocaine}}
Published	07/30/2024	Indirect-acting sympathomimeticsQC: Shorter lasting and more intense psychological effect(1) Amphetamine(2) Cocaine{{c1::1<2}}
Published	07/30/2024	Dopamine AgonistsProduces peripheral vasodilation in some vascular beds, used as IV treatment of severe hypertension{{c1::Fenoldopam}}
Published	07/30/2024	VR: Dobutamine → {{c1::increase}} coronary and systemic vasodilation
Published	07/30/2024	QC: Induces local vasoconstriciton(1) Epinephrine(2) Cocaine{{c1::1=2}}
Published	07/30/2024	QC: Used in combination with inhalational corticosteroids (to treat inflammation) for prophylactic/ prevention of asthma attacks(1) Short-acting …
Published	07/30/2024	Treatment for narcolepsy, ADHD, weight reduction (with appropriate control){{c1::Modafinil (Amphetamines)}}
Published	07/30/2024	Drug that decreases craving for narcotics, nicotine, and alcohol during withdrawal{{c1::Clonidine}}
Published	07/30/2024	VR: Clonidine → {{c1::increase}} salt and water absorption from the intestine
Published	07/30/2024	Drug that decreases menopausal hot flushes{{c1::Clonidine}}
Published	07/30/2024	Drug used for diarrhea in diabetics with autonomic neuropathy{{c1::Clonidine}}
Published	07/30/2024	{{c1::Beta-2::Alpha/Beta-1/Beta-2}} agonist Toxicity leads to skeletal muscle tremor
Published	07/30/2024	Adrenergic agonist toxicity in the periphery presents with:{{c1::Excessive vasoconstriction}}{{c1::Cardiac arrythmias}}{{c1::Myocardial infarctio…
Published	07/30/2024	Beta Selective AgonistsDobutamine ({{c1::+::+/-}}) isomer is an α1 antagonist (vasodilation)
Published	07/30/2024	QC: Norepinephrine (AKA {{c3::levaterenol, noradrenaline}}) receptor affinity:A1 {{c1::=::>/=/<}} A2B1 {{c2::>::>/=/<}} B2
Published	07/30/2024	Dopamine activates...{{c1::beta}} receptors at intermediate doses{{c1::alpha}} receptors at large doses
Published	07/30/2024	VR: 1. Beta antagonist 2. Glaucoma{{c1::B}}
Published	07/30/2024	VR: 1. A1 agonist 2. pupillary dilator contraction{{c1::A}}
Published	07/30/2024	Atomoxetine is used for treating {{c1::ADHD}}Reboxetine is used for treating {{c1::depression}}
Published	07/30/2024	VR: Increase in {{c1::A-2}} receptor stimulation → increase platelet aggregation
Published	07/30/2024	{{c1::D2}} receptors are targets for antipsychotic drugs
Published	07/30/2024	QC: Addition of -OH group on beta carbon on Phenylethylamine(1) Direct-acting sympathomimetic(2) Indirect-acting sympathomimetic{{c1::1>2…
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