Notes in CBB 37: Heme synthesis

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Published	09/14/2024	Porphyrins: {{c1::Cyclic compounds that bind metal ions like heme.::what are they?}}
Published	09/14/2024	Biosynthesis of Heme: Starting compounds: {{c1::Glycine}} & {{c1::succinyl CoA.}} Key enzymes: {{c2::ALA synthase …
Published	09/14/2024	Overview of Porphyria - General Features: Deficiency of enzymes in the heme biosynthesis pathway leads to {{c1::porphyria}}, which involves…
Published	09/14/2024	2. Overview of Porphyria a. General Features: Inheritance: Mostly {{c1::autosomal dominant}}. If accumulation occurs {{c2::after::before/after}} …
Published	09/14/2024	Overview of Porphyria - General Features{{c1::ALA}} buildup: Causes severe stomach pain and neuropathy, as this molecule has a structure sim…
Published	09/14/2024	Acute Intermittent Porphyria (AIP): Enzyme deficiency: {{c1::Porphobilinogen deaminase (aka hydroxymethylbilane synthase, HMB synthase).}} …
Published	09/14/2024	Porphyria Cutanea Tarda (PCT): Enzyme deficiency: {{c1::Uroporphyrinogen decarboxylase.}} Accumulation: {{c1::Uroporphyrin.}} Inheritance: …
Published	09/14/2024	Heme Degradation and Elimination - Degradation Process: Most heme for degradation comes from {{c1::red blood}} cell turnove…
Published	09/14/2024	Bilirubin UDP-Glucuronosyltransferase and Related Syndromes Crigler-Najjar and Gilbert Syndromes: Genetic deficiency of bilirubin UGT. Gil…
Published	09/14/2024	{{c1::Indirect}}Bilirubin (Unconjugated): {{c2::Not soluble in::soluble/non-soluble}} blood. Toxic to tissues. {{c1::Direct}}Bilirubin (Conjugated):…
Published	09/14/2024	Hemolytic Jaundice: Cause: Conditions involving {{c1::hemolytic anemia}} (e.g., sickle cell disease, G6PD deficiency). Mechanism: Over…
Published	09/14/2024	Hepatocellular Jaundice: Cause: {{c1::Liver damage}} reduces the liver's ability to conjugate bilirubin. Effect: Elevated levels of both conjuga…
Published	09/14/2024	Obstructive Jaundice: Cause: {{c1::Blockage of the bile duct}}, leading to accumulation of conjugated bilirubin. Effect: Conjugated biliru…
Published	09/14/2024	Neonatal Jaundice: Cause: {{c1::Increased RBC breakdown in newborns and low levels of bilirubin UGT in general.::(2)}} Effect: Common and genera…
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