Notes in CBB 34: lipoproteins

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Published	09/14/2024	Basic Steps of Cholesterol Synthesis  General Overview: Location: {{c1::Cytoplasm, Liver::organelle & organ}} Requirements: {{c2::Acetyl CoA…
Published	09/14/2024	Four Stages of cholestrol synthesis: Stage 1: {{c1::Synthesis of Mevalonate}} Stage 2: {{c1::Mevalonate → Activated Isoprenes}}Stage 3: …
Published	09/14/2024	Stage 1 of cholesterol synthesis. Formation of Mevalonate Steps: {{c1::Two::#}} acetyl CoA molecules → Acetoacetyl CoA {{c1::HMG CoA synth…
Published	09/14/2024	Regulation of HMG CoA Reductase (the rate limting enzyme of cholestrol synthesis; stage 1): Transcriptional regulation: High cholesterol,…
Published	09/14/2024	What is the drug class of Statins used for?: MoA: Competitively inhibit {{c1::HMG CoA reductase::enzyme}} Indication: {{c1::Hypercholesterolemi…
Published	09/14/2024	Fate of Cholesterol (will become...): {{c1::Free Cholesterol}}: Secreted via the {{c2::biliary tract::body area}} {{c1::Bile Salts/Acids…
Published	09/14/2024	Formation of bile salts:{{c1::Hydroxylation}} (rate-limiting)Activated cholesterol conjugates with glycine or taurine forming a bile salt.Function: {{…
Published	09/14/2024	Uses of Cholesterol: Membrane component Component of {{c1::bile}} Precursor: {{c1::Steroid}} hormones, Vitamin {{c1::D}}
Published	09/14/2024	Choleserol/lipid transport - Chylomicrons: Function: Transport {{c1::dietary triglycerides}} from {{c2::intestinal}} cells to {{c2::peripheral}}…
Published	09/14/2024	Deficiency: LPL or ApoC-II deficiency → {{c1::Hyperchylomicronemia}}, {{c1::Hypertriglyceridemia}}
Published	09/14/2024	Lipid/cholesterol transport - VLDL: Function: Transport {{c1::synthesized triglycerides}} from {{c2::liver}} to {{c2::peripheral}} tissues Apoli…
Published	09/14/2024	Lipid/cholesterol transport - LDL: Function: Transport {{c1::cholesterol}} to {{c1::peripheral}} tissues Pathway: VLDL loses TG (via lipo…
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