Notes in PHAR212 Rabies 2

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Published	03/12/2024	The 6 different states of the brain are{{c1::deathconvulsionsexcitationnormal operating brainslight loss of sensationtotal loss of sensationdeath}}
Published	03/12/2024	Drugs that modify the CNS action that move upward on the brain states are {{c1::CNS stimlants and anaesthesia antagonists}}Drugs that modify the CNS a…
Published	03/12/2024	Drugs can either switch on/speed up or switch off/slow down {{c1::action potentials}}
Published	03/12/2024	Drugs that increase CNS Action Potentials (switch on/speed up) will{{c1::increase the concentration of excitatory neurotransmitter}}{{c1::assist stimu…
Published	03/12/2024	Drugs that decrease (switch off/slow down) CNS Action Potentials{{c1::decrease concentration of excitatory neurotransmitter}}{{c1::inhibit s…
Published	03/12/2024	Anticonvulsant DrugsAre mostly {{c1::anesthetics}}Commonly used in humans and animalsInclude drug families such as:{{c2::Barbiturates}}{{c2::Benz…
Published	03/12/2024	Mechanism of Action and Examples (not required to know drug names){{c1::Barbiturates}}: {{c2::bind to GABA receptor (GABAA), increases influx of …
Published	03/12/2024	Tranquilizers, Ataractics, Neuroleptics, SedativesAre drugs to {{c1::calm down and promote the sleep}}Mechanism of action: {{c1::via dopamin…
Published	03/12/2024	Mechanism of Action of Tranquilizers, Antaractics, Neuroleptics, and Sedatives{{c1::Phenothiazine derivatives}}: {{c2::block dopamine receptors a…
Published	03/12/2024	Preanesthetic MedicationsImprove {{c1::rapidity and smoothness of the anesthetic induction}}Provide {{c1::analgesia and amnesia}}Prevent som…
Published	03/12/2024	Two types of Anesthetics{{c1::Local}}{{c2::TopicalParenteral}}{{c1::General}}{{c2::InhalantInjectable}}
Published	03/12/2024	Local AnestheticsMode of action: {{c1::prevent generation and conduction of impulse, by altering membrane permeability to Na+}} Uses: {{c2::…
Published	03/12/2024	Inhalant General AnesthesiaThese are the gases that act on {{c1::CNS and spinal cord}}They produce both {{c1::analgesia and unconsciousness}…
Published	03/12/2024	Injectable General Anesthesia{{c1::Barbiturates}}{{c1::Cycloheximides}}{{c2::Propofol (a substituted isopropylphenol)}}{{c2::Etomidate (a sedative hyp…
Published	03/12/2024	Methylxanthine DerivativesExamples:{{c1::Caffeine (coffee seeds)Theophylline (tea leaves) Theobromine (coca seeds)}}MOA: {{c2::Translocation of extrac…
Published	03/12/2024	NicotineMOA: In {{c1::low}} doses, ganglionic {{c2::stimulation}}In {{c1::high}} doses, ganglionic {{c2::blockade}}Pharmacological…
Published	03/12/2024	CocaineHighly addictive drug MOA:{{c1::It blocks the central & peripheral effects of NE, also blocks serotonin & dopamine reuptake into the pr…
Published	03/12/2024	AmphetamineAlmost similar to the cocaine MOA: {{c1::Elevation of catecholamine transmitters in synaptic spaces- releases intracellular stores of catec…
Published	03/12/2024	Psychotherapeutic Medications Dysfunction related to {{c1::neurotransmitter (monoamine) imbalance}} {{c2:: NorepinephrineDopamine Seroto…
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