Notes in 3. Pharmacology

To Subscribe, use this Key

Status	Last Update	Fields
Published	02/10/2024	Drugs that Affect Coagulation[1] {{c1::Unfractioned Heparin/Low Molecular Weight Heparin (LMWH) e.g. Enaxoparin, Dalteparin}}[2] {{c1::Warfarin}}…
Published	02/10/2024	Examples of {{c2::Low Molecular Weight Heparin (LMWH)}} {{c1::Enaxoparin}} {{c1::Dalteparin}} {{c1::Nadroparin}}
Published	02/10/2024	Mechanism of Action of {{c2::Unfractioned Heparin}} {{c1::Combines with antithrombin-III and increases its effectiveness by over 1000x}} {{c1::Inactiv…
Published	02/10/2024	Mechanism of Action of {{c2::Low Molecular Weight Heparin (LMWH)}} {{c1::Inactivates many factors e.g. 2, 8, 9, 10, 11, 12 (thrombin and 8-12)}} {{c1:…
Published	02/10/2024	Side Effects of {{c2::Heparin/LMWH}} Medication {{c1::Haemorrhage}} {{c1::Osteoporosis (in fractioned heparin)}} {{c1::Hyperkalaemia (due to inhibitio…
Published	02/10/2024	Both {{c1::Low Molecular Weight Heparin (LMWH)}} and {{c1::Unfractioned Heparin}} are anticoagulants that act on the {{c2::intrinsic}} pathway
Published	02/10/2024	Mechanism of Action of {{c2::Warfarin}} {{c1::Vitamin K antagonist which is essential for the formation of clotting factors 2, 7, 9, 10, and natural a…
Published	02/10/2024	{{c1::Warfarin}} is an anticoagulant that takes several days to develop its action, so {{c2::LMWH}} is prescribed in the first days
Published	02/10/2024	{{c1::Warfarin}} is an anticoagulant that acts on the {{c2::extrinsic}} pathway
Published	02/10/2024	Warfarin is monitored using the {{c1::prothrombin time (PT)}}, which is expressed as the {{c1::INR of (2-4)}}
Published	02/10/2024	Side Effects of {{c2::Warfarin}} Drug {{c1::Teratogenic (Not given in pregnancy at all)}} {{c1::Haemorrhage}} {{c1::Necrosis of soft tissues, in butto…
Published	02/10/2024	Examples of {{c2::Direct Oral AntiCoagulants (DOACs)}} {{c1::Dabigatran}}, {{c1::Bivalirudin}}, {{c1::Argatroban}} {{c1::Apixaban}}, {{c1::Rivaro…
Published	02/10/2024	Mechanism of Action of {{c2::Direct Oral AntiCoagulants (DOACs)}} Onset of action is within {{c1::3 hours}} {{c1::DabigaTran, BivalirudIN, ArgaTr…
Published	02/10/2024	Examples of {{c2::Fibrinolytic/Thrombolytic}} Drugs {{c1::Streptokinase}} {{c1::Alteplase}} {{c1::Reteplase}} {{c1::Tenecteplase}}
Published	02/10/2024	Mechanism of Action of {{c2::Fibrinolytic/Thrombolytic}} Drugs {{c1::Activation of plasminogen to plasmin to enhance fibrinolysis}}
Published	02/10/2024	Side Effects of {{c2::Fibrinolytic/Thrombolytic}} Drugs {{c1::Haemorrhage}} {{c1::Hypotension (most common with streptokinase)}} {{c1::Allergy}}
Published	02/10/2024	Indications of Thrombolysis {{c1::Myocardial infarction}} {{c1::Large ischaemic stroke}} {{c1::Life-threatening PE}}
Published	02/10/2024	Examples of {{c2::Antifibrinolytic/Haemostatic}} Drugs {{c1::Tranexamic acid}}{{c1::Aprotinin}}
Published	02/10/2024	Mechanism of Action of {{c2::Antifibrinolytic/Haemostatic}} Drugs {{c1::Tranexamic acid inhibits the activation of plasminogen which prevents fibrinol…
Status	Last Update	Fields