Notes in MSK Development

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Status	Last Update	Fields
Published	11/30/2024	Skeletal system originates from these sources:- {{c1::Paraxial mesoderm}}- {{c1::Parietal (somatic) layer of mesoderm}}- {{c1::Neural c…
Published	11/30/2024	Paraxial mesoderm form paired segments called {{c1::somites}} during end of week {{c2::3}}
Published	11/30/2024	Each somite forms two distinct zones- {{c1::Sclerotome}}- {{c1::Dermamyotome}}
Published	11/30/2024	Scleratome ultimately develops into {{c1::vertebrae and ribs}}
Published	11/30/2024	Dermamyotome ultimately develops into {{c1::dermis of skin covering true back muscles (dermatome), trunk muscles (epimere & hypomere), and li…
Published	11/30/2024	The parietal (somatic) layer of the lateral plate mesoderm ultimately develops into {{c1::bones of the appendicular skeleton (pelvic/shoulder gir…
Published	11/30/2024	bones of the vertebral column ultimately primarily develop from {{c1::paraxial}} mesoderm
Published	11/30/2024	bones of the pelvic girdle ultimately primarily develop from {{c1::lateral plate}} mesoderm
Published	11/30/2024	bones of the shoulder girdle ultimately primarily develop from {{c1::lateral plate}} mesoderm
Published	11/30/2024	Bones of the ribs ultimately primarily develop from {{c1::paraxial}} mesoderm
Published	11/30/2024	Portions of the skull ultimately primarily develop from {{c1::Paraxial}} mesoderm and neural crest
Published	11/30/2024	muscles of the trunk ultimately primarily develop from {{c1::paraxial}} mesoderm
Published	11/30/2024	Muscles of the limbs ultimately primarily develop from {{c1::paraxial}} mesoderm
Published	11/30/2024	dermis of the skin covering true back muscles ultimately primarily develop from {{c1::paraxial}} mesoderm
Published	11/30/2024	Bones of the limbs ultimately primarily develop from {{c1::lateral plate}} mesoderm
Published	11/30/2024	Bones of the sternum ultimately primarily develop from {{c1::lateral plate}} mesoderm
Published	11/30/2024	Dermis of the limbs ultimately primarily develop from {{c1::lateral plate}} mesoderm
Published	11/30/2024	Dermamyotome differentiates into {{c1::dermatome}} and {{c1::myotome}}
Published	11/30/2024	Myotome differentiates into {{c1::epimere}} and {{c1::hypomere}}
Published	11/30/2024	Syndetome develops between {{c1::sclerotome}} and {{c1::myotome}} ultimately becoming {{c2::tendons and ligaments}}
Published	11/30/2024	Sclerotome ultimately becomes- {{c1::Vertebrae}}- {{c1::Ribs}}
Published	11/30/2024	Dermamyotome ultimately becomes:- {{c1::Dermis of the back}}- {{c1::Muscles of trunk}}- {{c1::Muscles of limbs}}
Published	11/30/2024	How does resegmentation allow muscles to move the vertebral column?: {{c1::Splits the myotome resulting in the myotome forming to be in between t…
Published	11/30/2024	Notochord in the vertebral bodies {{c1::regresses entirely from the region::action}}
Published	11/30/2024	Notochord in the intervertebral discs {{c1::enlarge}} contributing to {{c1::nucleus polposus}}
Published	11/30/2024	During fetal development, 2 primary curvatures are established: {{c1::Thoracic}} and {{c1::Sacral}}
Published	11/30/2024	Thoracic and sacral are {{c1::kyphotic::kyphotic/lordonic}}
Published	11/30/2024	Cervical curvature develops during {{c1::week 12 - week 20 postnatal}} while learning to hold up their head
Published	11/30/2024	Lumbar curvature developes during {{c1::late infancy-early childhood::developmental periods}} while learning to walk
Published	11/30/2024	Congenital scoliosis: results in {{c1::lateral bending and/or rotation}} of vertebral column
Published	11/30/2024	Congenital scoliosis cause: {{c1::one vertebrae only forms on one side (hemivertebrae) during resegmentation}}
Published	11/30/2024	Hemivertebrae: {{c1::vertebrae that only forms on one side}}
Published	11/30/2024	Spina bifida occulta is an incomplete or missing {{c1::vertebral arch}}
Published	11/30/2024	Spina bifida occulta developmental cause: {{c1::imperfect fusion during resegmentation of dorsal/cranial sclerotome}}
Published	11/30/2024	Spina bifida occulta most common in {{c1::lumbar}} region
Published	11/30/2024	Chordoma: {{c1::rare neoplasm (tumor) along spinal cord}}
Published	11/30/2024	Each vertebrae initially develops {{c1::transverse process}} and {{c1::costal process}}
Published	11/30/2024	Cervical ribs development process : {{c1::costal process fuses with transverse process}}
Published	11/30/2024	Thoracic ribs development process: {{c1::costal process elongates to form ribs}}
Published	11/30/2024	Thoracic ribs begins to form and lengthen by {{c1::end of week 5::timing}}
Published	11/30/2024	Costal cartilage is formed by {{c1::sclerotome}} cells that migrate across the {{c2::adjacent lateral plate mesoderm}}
Published	11/30/2024	the first seven ribs connect to costal cartilage by week {{c1::6}}
Published	11/30/2024	Lumbar ribs development process: {{c1::costal process fuses with transverse process}}
Published	11/30/2024	sacral ribs development process: {{c1::Costal process forms the ala of the sacrum (lateral projections which articulate with the hip bones)}}
Published	11/30/2024	Ala: {{c1::lateral projections which articulate with the hip bones}}
Published	11/30/2024	extra ribs may form in the {{c1::lumbar and cervical}} regions
Published	11/30/2024	Extra ribs are also called {{c1::accessory ribs}}
Published	11/30/2024	sternum develops from {{c1::lateral plate}} mesoderm
Published	11/30/2024	Initially in sternum development, two {{c1::longitudinal mesenchymal condensations}} form called {{c2::sternal bars or bands}}
Published	11/30/2024	During week 7, sternal bars are pushed together because {{c1::most cranial ribs are long enough that they push the sternal bars together}}
Published	11/30/2024	The sternum fuses directionally {{c1::cranial}} to {{c1::caudal}}
Published	11/30/2024	Fusion completes at the xiphoid process by week {{c1::9}}
Published	11/30/2024	Cleft sternum: {{c1::sternal bands fail to fuse}}
Published	11/30/2024	Pectus excavatum: {{c1::depressed sternum}}
Published	11/30/2024	Pectus carinatum: {{c1::flattened chest bilaterally with anteriorly projecting sternum}}
Published	11/30/2024	Endochondral ossification: {{c1::cartilage model forms first which is eventually replaced by bone}}
Published	11/30/2024	Endochondral ossification forms: {{c1::the axial skeleton, cranial base, and appendicular (limb) skeleton except for the clavicles::structures}}
Published	11/30/2024	Intramembranous ossification: {{c1::bone forms directly from mesenchymal cells}}
Published	11/30/2024	Intramembranous ossification forms {{c1::the clavicle, cranial vault, and most of the facial bones::structures}}
Published	11/30/2024	Achondroplasia is an {{c1::autosomal dominant::inheritance pattern}} syndrome
Published	11/30/2024	Achondroplasia mutation: {{c1::genetic mutation that affects the ossification process of bones, especially long bones of upper and lower limbs}}
Published	11/30/2024	Achondroplasia presentation: {{c1::shorter bones (humerus/femur), bones with altered appearance, and shorter stature}}
Published	11/30/2024	Osteogenesis imperfecta: {{c1::group of genetic disorders that result in imperfect bone formation}}
Published	11/30/2024	Osteogenesis imperfecta is also known as {{c1::brittle bone disease}}
Published	11/30/2024	The muscular system develops from the {{c1::mesodermal}} germ layer with exception of {{c1::smooth muscle from neural crest cells}}
Published	11/30/2024	Dermomyotome differentiates and arrange themselves into 1 {{c1::central dermatome}} area and 2 {{c1::myotome}} areas
Published	11/30/2024	The dorsomedial myotome is called the {{c1::epimere}}
Published	11/30/2024	Epimere ultimatelly forms {{c1::true back muscles}}
Published	11/30/2024	The ventrolateral myotome is called the {{c1::hypomere}}
Published	11/30/2024	Hypomere ultimately forms {{c1::thoracic wall, abdominal wall, and limb muscles}}
Published	11/30/2024	Prune belly syndrome results in {{c1::partial or complete absence of abdominal musculature}}
Status	Last Update	Fields