Notes in Phagocytic Diseases

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Published	10/08/2024	Phagocitic disorders: Leukocyte Adhesion DeficiencyHappens due to lack of {{c1::Sialyl-Lewis X or CD18 receptor molecules on Leukocyte so it cann…
Published	10/08/2024	Phagocitic disorders: Leukocyte Adhesion Deficiency DIAGNOSIS{{c1::FBC with cell differential: Neutrophilia since they stay trapped in blood syst…
Published	10/08/2024	Phagocitic disorders: Leukocyte Adhesion Deficiency TREATMENT  (2){{c1::Prophylactic Abx & Antifungals (TMP/SMX and Itraconazole)De…
Published	10/08/2024	Phagocitic disorders: Chronic Granulomatous DiseaseCaused by a mutation in NADPH oxidase = phagocytes cannot produce O2-, H2O2 or CIO = {{c1…
Published	10/08/2024	Phagocitic disorders: Chronic Granulomatous DiseasePresents <5yo with the following symptoms:{{c1::Recurrent infections of skin, Resp tract, b…
Published	10/08/2024	Phagocitic disorders: Chronic Granulomatous Disease DIAGNOSIS (2){{c1::FBC: Normal NeutrophilsTest Neutrophil function via Dihydrohodamine 1…
Published	10/08/2024	Phagocitic disorders: Chronic Granulomatous Disease TREATMENT (3){{c1::Prophylactic AbxInterferon Gamma: stimulates superoxide in phagocytes…
Published	10/08/2024	Phagocitic disorders: Chediak Higashi SyndromeCaused by a mutation in {{c1::lysosomal trafficking regulator protein = neutrophils cannot phagocyt…
Published	10/08/2024	Phagocitic disorders: Chediak Higashi Syndrome DIAGNOSIS (2){{c1::FBC: decreased NeutrophilsConfirmation: blood smear showing inclusion bodies in…
Published	10/08/2024	Phagocitic disorders: Chediak Higashi Syndrome TREATMENT (2){{c1::Prophylactic Abx & antifungals e.g. TMP/SMX and ItraconazoleDefinitive…
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