Notes in 02 Receptors as Determinants of Quantitative Relations

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Status	Last Update	Fields
Published	07/30/2024	Variable RelationshipAs drug concentration increases, the response INCREMENT {{c1::decreases::increases/decreases/is not affected}}This relationship i…
Published	07/30/2024	Quantitative RelationshipEffect of drug on a system beginning with a(1) High Drug Concentration(2) Low Drug ConcentrationAnswer: 1 {{c1…
Published	07/30/2024	{{c1::Maximal Efficacy or Emax}} is the point where {{c2::response stops and maximum response is achieved.::(description of Emax)}}
Published	07/30/2024	The {{c1::Emax::EC50, Emax, Kd, Bmax}} of a drug refers to its {{c2::efficacy::potency/efficacy/affinity/receptor count}}
Published	07/30/2024	The {{c1::EC50::EC50, Emax, Kd, Bmax}} of a drug refers to its {{c2::potency::potency/efficacy/affinity/receptor count}}
Published	07/30/2024	The {{c1::Kd::EC50, Emax, Kd, Bmax}} of a drug refers to its {{c2::affinity::potency/efficacy/affinity/receptor count}}
Published	07/30/2024	The {{c1::Bmax::EC50, Emax, Kd, Bmax}} of a drug refers to its {{c2::receptor count::potency/efficacy/affinity/receptor count}}
Published	07/30/2024	Variable RelationshipAn increase of a drug's Emax will {{c1::increase::increase/decrease/not affect}} its maximal response.
Published	07/30/2024	Variable RelationshipAn increase of a drug's EC50 will {{c1::decrease::increase/decrease/not affect}} its potency.
Published	07/30/2024	Variable RelationshipAn increase of a drug's Kd will {{c1::decrease::increase/decrease/not affect}} its affinity.
Published	07/30/2024	Variable RelationshipAn increase of a drug's Bmax will {{c1::increase::increase/decrease/not affect}} its total number of receptor site…
Published	07/30/2024	{{c1::Kd}} is the variable that represents the drug concentration required to bind 50% of the receptors
Published	07/30/2024	{{c1::EC50}} is the variable that represents the drug concentration required to produce 50% of the maximal effect
Published	07/30/2024	{{c1::Coupling}} refers to the transduction process that links the {{c2::drug occupancy}} of receptors and the {{c2::pharmacologic response}…
Published	07/30/2024	Quantitative ComparisonKd of a drug compared to EC50 with(1) Presence of Spare Receptors(2) Absence of Spare ReceptorsAnswer: {{c1::1 &…
Published	07/30/2024	Quantitative ComparisonConcentration Needed to attain EC50(1) Presence of Spare Receptors(2) Absence of Spare ReceptorsAnswer: {{c1::1 < 2}}
Published	07/30/2024	Which among the 5 curves represent the attainment of maximal efficacy?{{c1::Curves A, B, C}}
Published	07/30/2024	Which among the 5 curves represent failure to reach maximum efficacy?{{c1::Curves D, E}}
Published	07/30/2024	Which among the 5 curves represent the presence of an agonist in the absence of an antagonist?{{c1::Curve A}}
Published	07/30/2024	Which among the 5 curves represent the presence of an agonist alongside low concentrations of antagonists?{{c1::Curve B}}
Published	07/30/2024	Which among the 5 curves represent the presence of an agonist alongside high concentrations of antagonists?{{c1::Curve C}}
Published	07/30/2024	Which among the 5 curves represent the presence of an agonist alongside very high concentrations of antagonists with saturated spare receptors?{{c1::C…
Published	07/30/2024	The concentration-effect curve of an agonist + competitive antagonist shifts {{c1::rightward::upward/downward/leftward/rightward}}
Published	07/30/2024	The concentration-effect curve of an agonist + irreversible antagonist shifts {{c1::downward::upward/downward/leftward/rightward}}
Published	07/30/2024	Identify the type of Antagonist presentAntagonists and agonists occupy the same type of receptorType: {{c1::Competitive or Reversible}}
Published	07/30/2024	Identify the type of Antagonist presentAntagonist binds to the receptor using covalent bonds possibly on an allosteric siteType: {{c1::Noncompeti…
Published	07/30/2024	Identify the type of Antagonist presentDrug does not depend on agonist-receptor interactionType: {{c1::Chemical}}
Published	07/30/2024	Identify the type of Antagonist presentAntagonist makes use of regulatory pathwaysType: {{c1::Physiologic}}
Published	07/30/2024	Identify the type of Antagonist presentAntagonist binds to a different receptor in order to produce an effect opposing the one produced by the drug it…
Published	07/30/2024	Variable Relationship(1) Competitive Antagonism(2) ED50 of Agonist{{c1::Inc-Inc::Inc-Inc, Inc-Dec, No Effect}}
Published	07/30/2024	Variable Relationship(1) Salbutamol(2) Beta-2 receptor activity{{c1::Inc-Inc::Inc-Inc, Inc-Dec, No Effect}}
Published	07/30/2024	Variable Relationship(1) Protamine(2) Heparin activity{{c1::Inc-Dec::Inc-Inc, Inc-Dec, No Effect}}
Published	07/30/2024	Variable Relationship(1) Salbutamol(2) Histamine activity{{c1::Inc-Dec::Inc-Inc, Inc-Dec, No Effect}}
Published	07/30/2024	[VR] 1. Non-competetive inhibition 2. ED50 {{c1::C}}
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