Notes in Pharm 117

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Published	09/15/2023	Pharmaceutics: {{c1::formulation}} and {{c2::dosage forms}}.
Published	09/15/2023	Pharmacokinetics: {{c1::drug absorption}}, {{c2::distribution}} and {{c3::metabolism}}.
Published	09/15/2023	Pharmacodynamics: {{c1::drug/receptor}} interactions
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Published	09/15/2023	{{c2::Pharmaceutics}}: the art and science of using physiochemical properties to allow the incorporation of an {{c1::active pharmaceutical ingredient …
Published	09/15/2023	Pharmaceutics requires knowledge of: {{c1::physical states}} and {{c3::chemistry of components}} of, and {{c2::purpose}} of drug product.
Published	09/15/2023	The final drug product is in a particular {{c1::dosage form}}.
Published	09/15/2023	Dosage forms: contain the {{c1::API}} in association with other inactive ingredients, also called {{c2::excipients}}, that form a vehicle, or {{c3::fo…
Published	09/15/2023	Dosage forms can be {{c1::solid}}, {{c1::semi-solid}}, {{c1::liquid}} or {{c1::gas}}.
Published	09/15/2023	Dosage forms are suited to {{c1::drug purpose}}.
Published	09/15/2023	Dosage forms insure the {{c1::stability}} of the API upon storage.
Published	09/15/2023	Dosage forms provide {{c1::convenience}} (patient compliance).
Published	09/15/2023	Dosage form is designed to {{c1::release the API}} in the context of route of delivery.
Published	09/15/2023	Why so many different Dosage forms?:1. {{c1::Route of delivery}}2. {{c1::Drug stability}}: both environmental and metabolism3. {{c1::Disease context (…
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Published	09/15/2023	Administration of Drug Therapy:1. Pathology indicates {{c1::drug therapy}} (pharmaceutical care)2. Drug product ({{c1::dosage form}}) containing appro…
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Published	09/15/2023	Drugs carried in blood have a {{c1::reversible}} binding to Albumin.
Published	09/15/2023	There is {{c1::retention}} of Protein-Bound drug within Vasculature.
Published	09/15/2023	Describe Drug First-pass metabolism
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Published	09/15/2023	Dosage form must consider: 1. {{c1::Patient pathological context}} (route of delivery)2. {{c1::Patient compliance}}3. {{c1::Drug storage requirem…
Published	09/15/2023	Roles of Excipients:1. {{c1::Aid in the processing of drug delivery system during its manufacture.}}2. {{c2::Protect, support, or enhance stability, b…
Published	09/15/2023	{{c1::Excipients}} can enchance drug solubility.
Published	09/15/2023	The drug (API) molecule can have different {{c1::solid}} forms.
Published	09/15/2023	{{c1::Electronegativity}} is the affinity an element or compound has for electrons.
Published	09/15/2023	Atoms or compounds with {{c1::greater}} electronegativity draw electrons from those with {{c1::lower}} affinity.
Published	09/15/2023	{{c1::Polarization}} of a covalent bond leaves a {{c2::partial positive}} charge and a matching {{c3::partial negative}} charge. Different levels of p…
Published	09/15/2023	Polarity of a covalent bond is correlated with difference of electron negativity of two atoms where a difference of at least {{c1::0.5}} is polar and …
Published	09/15/2023	Organic compounds can be categorized into: {{c1::Hydrogen}}, {{c1::Carbon}}, and {{c1::Hetero Atoms}}, where Hetero atoms stand for any {{c1::other no…
Published	09/15/2023	Polarity of a covalent bond in pharmaceutical or biological compound follows the rank: {{c1::X-H > X-C > C-H > C-C (where X is hetero)}}
Published	09/15/2023	Attraction between molecules {{c1::increases}} as they come closer but when too close {{c1::strong repulsion}} occurs.
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Published	09/15/2023	Hydrophilic: {{c1::water-loving.}}Lipophobic: {{c1::lipid-fearing.}}Lipophilic: {{c1::lipid-loving}}Hydrophobic: {{c1::water-fearing}}
Published	09/15/2023	Hydrocarbons are non-polar and thus {{c1::extremely weak}} acids.
Published	09/15/2023	Name 4 hydrocarbon functional groups:
Published	09/15/2023	Oils from cotton seed, grapeseed, sesame seed, and other plants serve as {{c1::excipients}} for IM injection for {{c1::hydrophobic}} drugs.
Published	09/15/2023	Alkyl and aryl halides are {{c1::non-polar}}.
Published	09/15/2023	{{c1::Alkyl halides}}: halogen, X, is directly bonded to sp3 carbon.{{c1::Vinyl halides}}: X is bonded to sp2 carbon of alkene{{c1::Aryl hal…
Published	09/15/2023	Some {{c1::sulfur containing}} functional groups are non-polar.
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