Notes in 02_PSC

To Subscribe, use this Key

Status	Last Update	Fields
Published	02/10/2024	{{c1::Primary Sclerosing Cholangitis (PSC)}} is a condition where {{c2::the intrahepatic or extrahepatic ducts become strictured and fibrotic, ca…
Published	02/10/2024	{{c1::Sclerosis}} refers to the stiffening and hardening of the bile ducts
Published	02/10/2024	{{c1::Cholangitis}} is inflammation of the bile ducts
Published	02/10/2024	Chronic bile obstruction eventually leads to {{c1::liver inflammation (hepatitis)}}, {{c1::fibrosis}} and {{c1::cirrhosis}}.
Published	02/10/2024	Causes of Primary Sclerosing Cholangitis (PSC) are unclear but there is an established association with {{c1::Ulcerative colitis}} in 70% of…
Published	02/10/2024	Risk factors of Primary Sclerosing Cholangitis (PSC){{c1::Male}} {{c1::Aged 30-40}} {{c1::Ulcerative Colitis}} {{c1::Family History}}
Published	02/10/2024	Presentation of {{c2::Primary Sclerosing Cholangitis (PSC)}}{{c1::Jaundice}} {{c1::Chronic right upper quadrant (RUQ) pain}} {{c1::Pruritus}} {{c1::Fa…
Published	02/10/2024	Complications of PSC:{{c1::Acute bacterial cholangitis}} {{c1::Cholangiocarcinoma}} develops in 10—20% of cases {{c1::Colorectal cancer}} {{c1::Cirrho…
Published	02/10/2024	Liver Function Tests (LFTs) of a Primary Sclerosing Cholangitis (PSC) patient show a cholestatic picture meaning that {{c1::alkaline ph…
Published	02/10/2024	{{c1::Bilirubin}} rises as the strictures caused by PSC become more severe and the bile duct more constricted
Published	02/10/2024	As PSC progresses to hepatitis which LFTs would become deranged?Other LFTs → i.e. transaminases: {{c1::Alanine transaminase (ALT)}} and {{c1::Aspartat…
Published	02/10/2024	Gold standard investigation for diagnosis of PSC is an {{c1::MRCP}}
Published	02/10/2024	{{c1::ERCP}} can be used to manage PSC by {{c2::dilating}} and {{c2::stenting}} any strictures caused by it.
Published	02/10/2024	Explain how an ERCP works:{{c1::ERCP (Endoscopic Retrograde Cholangio-Pancreatography) involves inserting a camera through the persons throat, oesopha…
Published	02/10/2024	{{c1::Colestyramine}} is a bile acid sequestrate, used to manage PSC, by binding to bile acids to prevent absorption in the gut.
Published	02/10/2024	{{c1::Colestyramine}} is a bile acid sequestrate that can help with pruritus by lowering raised bile acid levels
Status	Last Update	Fields