Notes in TB002 Red Blood Cell Disorders

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Published	10/19/2024	Key observations in peripheral blood smear
Published	10/19/2024	How is a blood smear made?
Published	10/19/2024	Key features of erythrocytes in peripheral blood smear:
Published	10/19/2024	Key features of reticulocytes in peripheral blood smear:
Published	10/19/2024	Key features of platelets in peripheral blood smear:
Published	10/19/2024	Key features of leukocytes in peripheral blood smear:
Published	10/19/2024	Key features of lymphocytes in peripheral blood smear:
Published	10/19/2024	Key features of monocytes in peripheral blood smear:
Published	10/19/2024	How can you identify polymorphonuclear leukocytes in a peripheral blood smear?
Published	10/19/2024	Key features of neutrophils in peripheral blood smear:
Published	10/20/2024	Key features of eosinophils in peripheral blood smear:
Published	10/19/2024	Key features of basophils in peripheral blood smear:
Published	10/19/2024	Normal hemoglobin structure
Published	10/19/2024	Sickle hemoglobin (Hgb S) results from a point mutation in the {{c1::beta globin gene at position 6}}, in which the normal {{c2::glutamate}} is r…
Published	10/19/2024	In patients with Hgb S, the {{c1::deoxygenated form}} of Hgb S bears a conformational change in which the β subunits move away from each other, and a …
Published	10/19/2024	The laboratory diagnosis of sickle cell disease relies upon {{c1::hemoglobin electrophoresis}} to identify the presence of an {{c2::abnormal Hgb S pro…
Published	10/19/2024	The hemoglobin electrophoresis in patients with Hgb S trait typically shows about {{c1::60% Hgb A, 35% Hgb S, and 3-5% Hgb A2}}.
Published	10/19/2024	Sickle cell trait is generally a clinically silent disorder, while sickle cell disease is associated with a number of complications that arise primari…
Published	10/24/2024	{{c1::Transfusion of wild-type packed red blood cells (PRBC)}} can treat or prevent many of the complications of sickle cell but carries its own set o…
Published	10/19/2024	In sickle cell disease treatment, {{c1::red cell exchange transfusions }}are indicated in acute chest syndrome but may be logistically difficult to pe…
Published	10/19/2024	What is this lab test/what is it used for?
Published	10/19/2024	What is this lab test/what is it used for?
Published	10/19/2024	Stages of neutrophil differentiation
Published	10/19/2024	Consider a patient with a WBC count of 24,000/µn;L (normal 4-10,000) and the following blood smear.What are the steps in evaluating this patient's leu…
Published	10/19/2024	Consider a patient with a WBC count of 24,000/µn;L (normal 4-10,000) and a blood smear showing signs of eosinophilia. What are the primary and seconda…
Published	10/19/2024	Consider a patient with a WBC count of 24,000/µn;L (normal 4-10,000) and a blood smear showing signs of monocytosis. What are the primary and secondar…
Published	10/19/2024	Consider a patient with a WBC count of 24,000/µn;L (normal 4-10,000) and a blood smear showing signs of basophilia. What are the primary and secondary…
Published	10/19/2024	What are the characteristic cells in this blood smear?
Published	10/19/2024	Myeloproliferative neoplasms (MPN) are a heterogeneous group of disorders characterized by {{c1::excessive proliferation of different hematopoietic ce…
Published	10/19/2024	There are four MPNs:{{c1::Polycythemia vera (PV)}} is characterized by an increase in hemoglobin and hematocrit with an increase in red cell mass.{{c2…
Published	10/19/2024	Major molecular mutations underlying MPNs?
Published	10/19/2024	Some of the major CD proteins in B cell development are {{c1::CD19 and CD20}}, which are produced throughout much of B cell development; {{c2::CD10}},…
Published	10/19/2024	Some of the major CD proteins in T cell development are {{c3::CD3}}, which is present on all T cells; CD4, which identifies CD4+ {{c4::helper T}} cell…
Published	10/19/2024	What is this cell?
Published	10/19/2024	Identify these cells:
Published	10/19/2024	What does this flow cytometry plot show?
Published	10/19/2024	This schematic shows the key structural features of what organ?
Published	10/19/2024	Consider a college student who presents to urgent care clinic with two weeks of fever, profound malaise, a sore throat, and swollen cervical lymph nod…
Published	10/19/2024	Consider the case of an elderly man who is found to have an elevation in lymphocyte count, diffuse lymphadenopathy, and the following smear. What is t…
Published	10/19/2024	Identify this cell:
Published	10/19/2024	What is this cell and in what condition will these cells be elevated?
Published	10/19/2024	Which of the following components is/are found in the dark, blue granules in the cell in the center of the image?
Published	10/19/2024	Identify the cell with a nucleus
Published	10/19/2024	Under which condition would you expect to see an increased number of these cells?
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