Notes in 04 Hematopoietic Stem Cells, Hematologic Cancer Therapeutics and Pharmacology

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Published	12/07/2023	Which type of transplant rejection presents as grafted immunocompetent T cells proliferating and rejecting host cells with "foreign" proteins? {{c1::G…
Published	12/07/2023	Which type of transplant rejection presents with maculopapular rash, jaundice, diarrhea, and hepatosplenomegaly? {{c1::Graft-versus-host-disease (GVHD…
Published	12/07/2023	What is the suffix for small molecule kinase inhibitors? {{c1::-nib}}
Published	12/07/2023	Chimeric biologics can be recognized as their names will include the infix -{{c1::xi}}-
Published	12/07/2023	{{c3::Methotrexate}} is a(n) {{c2::folic acid}} analogue that blocks pyrimidine synthesis by competitively inhibiting {{c1::dihydrofolate reducta…
Published	12/07/2023	As an antineoplastic, Methotrexate is primarily indicated for cancers of lymphocytes, particularly {{c1::leukemias}} and {{c2::lymphomas}}
Published	12/07/2023	Rituximab and Cetuximab are {{c1::Chimeric}} monoclonal antibodies
Published	12/07/2023	Tisagenlecleucel is a CAR T-cell Therapy that is indicated for relapsed {{c1::B-cell acute lymphoblastic leukemia (B-ALL)}} by targeting the {{c2::CD1…
Published	12/07/2023	Methotrexate is a(n) {{c1::folate}} analog
Published	12/07/2023	Which phase of the cell cycle does methotrexate act at?{{c1::S phase}}
Published	12/07/2023	What class of drugs does cyclophosphamide belong to?{{c1::Alkylating agents (cytotoxic chemo)}}
Published	12/07/2023	Which alkylating agent is used to treat both hematologic malignancies (leukemia, lymphoma) and solid tumors?{{c1::Cyclophosphamide}}
Published	12/07/2023	Which of the alkylating agents are nitrogen mustards?{{c1::Cyclophosphamide, Ifosfamide::2}}
Published	12/07/2023	Graft-versus-Host disease is due to {{c1::graft T}}-cells attacking the host
Published	12/07/2023	Imatinib (Gleevec) specifically kills cancer cells because it targets {{c1::Bcr-Abl fusion protein kinase}}
Published	12/07/2023	Rituximab treats certain cancers because it is made of antibodies against {{c1::CD20::specific molecule}} on {{c2::B cells::cell type}}
Published	12/07/2023	{{c1::minor Histocompatibility Antigen (mHA)}} is any donor peptide that could be presented to a host T cell even after HLA matching
Published	12/07/2023	To prevent {{c2::hyperacute transplant rejection::transplant response(s)}}, {{c1::ABO}} needs to match exactly, but {{c1::HLA}} matching is …
Published	12/07/2023	The most common complication of a hematopoietic stem cell transplant is {{c1::graft versus host disease (GVHD)}}
Published	12/07/2023	To prevent {{c2::graft-versus-host disease::transplant response(s)}}, {{c1::HLA}} matching is important but {{c1::ABO}} matching is not
Published	12/07/2023	CAR T-cell therapies have been approved for the treatment of malignancies caused by proliferation of {{c1::B cells}}
Published	12/07/2023	Steroids are included in many chemotherapy regimens (e.g. ABVD, R-CHOP) to reduce {{c1::nausea/vomiting::sx}} and inflammation due to {{c2::…
Published	12/07/2023	Steroids directly inhibit division of {{c1::lymphocyte}} cancers
Published	12/07/2023	Will allogeneic stem cell transplant induce graft-versus-tumor effect?{{c1::Yes}}
Published	12/07/2023	Will autologous stem cell transplant induce graft-versus-tumor effect?{{c1::No}}
Published	08/30/2024	In {{c1::Graft Vs Luekemia}}, the Donor HSCs will be able to recognize and target the leukemia bc of the {{c2::minor HLA type difference}}
Published	12/07/2023	A {{c1::Chimeric Antigen Receptor (CAR) T-cell}} combines a {{c2::genetically engineered antibody recognizer}} with the {{c2::killing machin…
Published	12/07/2023	{{c1::Blinatumomab}} is a {{c2::Bispecific T-cell Engager (BiTE)}} that brings the {{c3::CAR-T cell and the cancer cell}} closer together
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