Notes in Sickle Cell Disease

To Subscribe, use this Key

Status	Last Update	Fields
Published	10/08/2024	Sickle cell anaemia is a {{c1::genetic}} condition that causes sickle shaped red blood cells.The abnormal shape makes the red bloo…
Published	10/08/2024	Pathophysiology of Sickle Cell Disease:Haemoglobin is the protein in red blood cells that transports oxygen. During fetal development, at around …
Published	10/08/2024	Screening for Sickle Cell Disease:Sickle cell disease is tested for on the {{c1::newborn blood spot}} screening test at around five days of …
Published	10/08/2024	Signs & Symptoms of Sickle Cell Disease:{{c1::Anaemia}}: {{c2::pallor, dyspnea, fatigue}}{{c1::Jaundice}} due to increased haemolysis{{c1::Pain/si…
Published	10/08/2024	Complications of sickle cell disease:AnaemiaJaundice & haemolytic anaemiaFunctional aspelnia and hence an increased risk for {{c1::infection}}Stro…
Published	10/08/2024	Sickle cell crises can be moderate or life-threatening. They can occur spontaneously or triggered by {{c1::dehydration}}, {{c1::infecti…
Published	10/08/2024	Treatment for a sickle cell crisis is {{c1::supportive}}! This includes {{c1::warming, hydration, analgesia , treating infections}}
Published	10/08/2024	A {{c1::vaso-occlusive}} crisis is the most common type of sickle cell crisis. It is caused by the sickle-shaped red blood cells clogging ca…
Published	10/08/2024	{{c1::Splenic sequestration}} crisis is another type of sickle cell crisis. This is caused by red blood cells blocking blood flow within the&nbsp…
Published	10/08/2024	In sickle cell disease, splenic sequestration crisis can lead to splenic infarction, leading to functional asplenia and susceptibi…
Published	10/08/2024	Aplastic crisis is a third type of sickle cell crisis. It describes a {{c1::temporary absence of the creation of new red blood cells}} and is usually …
Published	10/08/2024	Acute Chest Syndrome in Sickle Cell Disease: Management (5){{c1::AnalgesiaIV Resus Antibiotics or antivirals for infectionBlood tr…
Published	10/08/2024	General management of Sickle Cell Disease:MDT!!{{c1::Specialist haematology clinic}} as well as general pediatricianPatient education is crucial: {{c1…
Published	10/08/2024	Hydroxyurea works by {{c1::increasing foetal haemoglobin}} in sickle cell patients, resulting in a lower number of sickle-shaped RBCs and thus decreas…
Published	10/08/2024	{{c1::Crizanlizumab}} is a monoclonal antibody that targets {{c1::P-selectin}}. This is an adhesion molecule found on&nb…
Status	Last Update	Fields