Notes in f. Protein Trafficking: Endocytosis, Endosomes, and Lysosomes

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Published	07/28/2024	{{c1::Phagocytosis}} is the process of endocytosis in which large particles are ingested
Published	07/28/2024	{{c1::pinocytosis}} is a form of endocytosis in which non-specific ingestion of fluid and solutes occurs via small vesicles
Published	07/28/2024	{{c1::receptor mediated endocytosis}} is a type of endocytosis in which ingestion of specific molecules occurs via ligand binding to receptors using v…
Published	07/28/2024	How are substrates released from their receptors in the early endosome?
Published	07/28/2024	What is the fate of the plasma membrane receptor after being incorporated into the early endosome?
Published	07/28/2024	Endosomes have a {{c1::low}} pH due to {{c2::Vaculoar ATPase}}
Published	07/28/2024	Familial hypercholesterolemia can results from defects in {{c1::LDL receptor function}}
Published	07/28/2024	An alternative cause to familial hypercholesterolemia that do not include defects in the LDL receptors ability to bind LDL is?
Published	07/28/2024	{{c1::Opportunistic ligands}} are toxins and viruses that can bind to cell surface receptors and use receptor-mediated endocytosis and low pH of endos…
Published	07/28/2024	Diptheria toxin is an example of an {{c1::opportunistic ligand}}
Published	07/28/2024	What is the basic mechanism of diptheria toxin?
Published	07/28/2024	How can receptor mediated endocytosis be down regulated?
Published	07/28/2024	What allows for transport of molecules taken up at the apical membrane to be delivered to the basolateral membrane?
Published	07/28/2024	Lysosomes are acidic organelles that utilize {{c1::hydrolases}} for enzymatic digestion and acidification achieved by vacuolar {{c1::ATPase}}
Published	07/28/2024	The acidification of the lysosome is achieved by the {{c1::vacuolar ATPase}}
Published	07/28/2024	Gaucher's, Tay-Sach's, and Niemann Pick diseases are example lipidoses lysosomal storage disease that are caused by?
Published	07/28/2024	Wolman's disease is an example of a lipidoses lysosomal storage disease that is caused by?
Published	07/28/2024	Hurler's, Hunt's, Sanfilippo A/B/C/D diseases are mucopolysaccharidoses lyposomal storage disease caused by?
Published	07/28/2024	What causes I-Cell (inclusion cell) disease?
Published	07/28/2024	In I-Cell disease, cells have large {{c1::inclusions}} due to accumulation of undegraded substances
Published	07/28/2024	In I-Cell disease, many cells are missing {{c1::lysosomal enzymes}}
Published	07/28/2024	I-Cell disease is caused by a defect in the {{c1::GlcNAc phosphotransferase (N-acetylglucosamine-1-phosphotransferase)}}, therefore {{c2::ma…
Published	07/28/2024	The transferrin and transferrin receptor are another example of {{c1::receptor}} mediated {{c1::endocytosis}} and {{c1::recycling}}
Published	07/28/2024	Diptheria toxin causes {{c1::ADP}} {{c1::ribosylation}} of {{c2::elongation factor 2}} which prevents translation from ocurring
Published	07/28/2024	{{c1::epidermal growth factor receptor}} is an example of receptor down regulation following mediated endocytosis
Published	07/28/2024	late endosomes are {{c1::acidic}} with a pH around {{c1::5.5-6.0}} which form lysosomes by a {{c2::further decrease}} in pH
Published	07/28/2024	Mannose-6-phosphate tag gets added to target {{c1::degradative}} enzymes which are destined for trafficking to {{c1::lysosomes}} in a {{c2::2}} step r…
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