Notes in Case 2: Hodgkin's Lymphoma

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Status	Last Update	Fields
Published	12/09/2023	{{c2::Mantle cell}} lymphoma is driven by a t({{c1::11}};{{c1::14}}) translocation
Published	12/09/2023	The t({{c3::11}};{{c3::14}}) translocation results in overexpression of {{c1::cyclin D1}}, which promotes the {{c2::G1/S}} transition in the cell cycl…
Published	12/09/2023	{{c2::Burkitt}} lymphoma is driven by a t({{c1::8}};{{c1::14}}) translocation
Published	12/09/2023	The t({{c2::8}};{{c2::14}}) translocation results in overexpression of {{c1::c-myc}}, which promotes growth
Published	12/09/2023	Reed-Sternberg cells secrete {{c1::cytokines}}, which attract other inflammatory cells
Published	12/09/2023	Reed-Sternberg cells occasionally result in "{{c1::B}}" symptoms (fever, chills, weight loss, night sweats)
Published	12/09/2023	What is the most common subtype of Hodgkin lymphoma (70%)? {{c1::Nodular sclerosis (NSHL)}}
Published	12/09/2023	What demographic is classically associated with the nodular sclerosis subtype of Hodgkin lymphoma (NSHL)? {{c1::Young adult females::age and gender}}
Published	12/09/2023	The {{c1::nodular sclerosis}} subtype of Hodgkin lymphoma typically presents as an enlarging cervical or {{c2::mediastinal}} lymph node in a female
Published	12/09/2023	Which subtype of Hodgkin lymphoma has the best prognosis? {{c1::Lymphocyte-rich}}
Published	12/09/2023	Which subtype of Hodgkin lymphoma is often associated with abundant eosinophils? {{c1::Mixed-cellularity (MCHL)}}
Published	12/09/2023	Which subtype of Hodgkin lymphoma is the most aggressive? {{c1::Lymphocyte-depleted}}
Published	12/09/2023	Which type of lymphoma is characterized by contiguous spread? {{c1::Hodgkin lymphoma::Hodgkin or non-Hodgkin}}
Published	12/09/2023	Which type of lymphoma is characterized by non-contiguous spread? {{c1::Non-Hodgkin lymphoma::Hodgkin or non-Hodgkin}}
Published	12/09/2023	Which type of lymphoma is more strongly associated with extranodal involvement? {{c1::Non-Hodgkin lymphoma::Hodgkin or non-Hodgkin}}
Published	12/09/2023	{{c2::Staging::Grading vs. Staging}} is the strongest predictor of prognosis for {{c1::Hodgkin::Hodgkin or non-Hodgkin}} lymphoma
Published	12/09/2023	{{c1::Chemotherapy ± radiation}} is the mainstay of treatment for Hodgkin lymphoma
Published	12/09/2023	Hodgkin lymphoma has a bimodal distribution: common in {{c1::young adulthood}} and {{c2::adults > 55 years}}
Published	12/09/2023	Hodgkin lymphoma is associated with {{c1::EBV}} infection
Published	12/09/2023	Lymphomas are malignancies of {{c1::mature}} leukocytes, whereas leukemias are malignancies of {{c1::immature}} leukocytes
Published	12/09/2023	What class of drugs does doxorubicin belong to?{{c1::Anthracyclines (antitumor antibiotics)}}
Published	12/09/2023	Anthracycline antitumor antibiotics were first isolated from a species of {{c1::Actinomyces}} bacteria
Published	12/09/2023	Anthracyclines (doxorubicin, daunorubicin, idarubicin) form {{c1::free radicals}} which cause breaks in {{c1::DNA}}
Published	12/09/2023	Which chemotherapeutic drugs form free radicals and also intercalate into DNA?{{c1::Anthracyclines (doxorubicin, daunorubicin, idarubicin)}}
Published	12/09/2023	Which antitumor antibiotic drug solely forms free radicals, causing strand breaks in DNA?{{c1::Bleomycin}}
Published	12/09/2023	Which antitumor antibiotic drug solely intercalates into DNA?{{c1::Dactinomycin (actinomycin D)}}
Published	12/09/2023	Anthracyclines (doxorubicin, daunorubicin, idarubicin) {{c1::intercalate}} into {{c2::DNA}}, blocking DNA and RNA synthesis
Published	12/09/2023	Hodgkin lymphoma can be classified as classical or more rarely, {{c1::nodular lymphocyte-predominant}}
Published	12/09/2023	Nodular lymphocyte-predominant Hodgkin lymphoma is a rare variant that is characterized by "{{c1::popcorn}} cells"
Published	12/09/2023	Nodular lymphocyte-predominant Hodgkin lymphoma has unusual surface marker expression in that it usually lacks CD15 and CD30 but expresses CD{{c1::19}…
Published	12/09/2023	{{c1::Hodgkin lymphoma::Condition}} is managed with ABVD chemotherapy regimen{{c1::Non-Hodgkin lymphoma::Condition}} is managed with R-CHOP therapy
Published	01/02/2024	Cancerous masses light up on PET-CT because the radiolabeled sugars are broken down in the cancer cells, since cancer cells tend to use more {{c1::ene…
Published	12/09/2023	CD34+ cells are {{c1::blasts/immature cells}}
Published	01/02/2024	Why are CD34+ cells are stimulated before stem cell transplantation?This increases the {{c1::survival}} and {{c1::proliferative}} ability of the cells…
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Status	Last Update	Fields