Notes in IIA. Viral Infections [HPV to HSV]

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Status	Last Update	Fields
Published	02/16/2025	{{c1::Human Papillomavirus}}● Naked icosahedral symmetry● Double stranded DNA, circular, replicated in nucleus● Pathognomonic sign: Presence of {{c2::…
Published	02/16/2025	{{c1::Human Papillomavirus}}● Most common type of STD around the world according tothe Center for Disease Control and World HealthOrganization○ More t…
Published	02/16/2025	{{c1::Human Papillomavirus}}Transmission of viral infections occur by close contact● Viral particles are released from the surface of the{{c2::papillo…
Published	02/16/2025	{{c1::Human Papillomavirus}}● Microabrasions allow infection of proliferating {{c2::basal layer}}cells at other sites or within different hosts● Papil…
Published	02/16/2025	Based on the relative occurrence of viral DNA in certaincancers, HPV types {{c1::16}} and {{c1::18}} are considered to be highcancer risks
Published	02/16/2025	Skin carcinomas appear to harbor HPV genomes in an{{c1::episomal}} state
Published	02/16/2025	Viral early proteins {{c1::E6}} and {{c1::E7}} are synthesized incancer tissue■ HPV-transforming proteins able to complexwith Rb and p53, and other ce…
Published	02/16/2025	HPV Mode of Transmission● {{c1::Direct Contact}}● {{c1::Minor Skin Abrasions}}● {{c1::Sexual Contact}}● {{c1::Vertical transmission - mother to baby}}
Published	02/16/2025	{{c1::image-occlusion:rect:left=.2641:top=.2586:width=.0941:height=.027:oi=1}}
Published	02/16/2025	{{c1::image-occlusion:rect:left=.2583:top=.3216:width=.1505:height=.036:oi=1}}
Published	02/16/2025	{{c1::image-occlusion:rect:left=.2612:top=.3779:width=.1433:height=.0473:oi=1}}
Published	02/16/2025	{{c1::image-occlusion:rect:left=.2598:top=.4432:width=.2272:height=.0428:oi=1}}
Published	02/16/2025	{{c1::image-occlusion:rect:left=.2569:top=.5467:width=.4038:height=.063:oi=1}}
Published	02/16/2025	{{c1::image-occlusion:rect:left=.254:top=.6435:width=.1867:height=.0405:oi=1}}
Published	02/16/2025	{{c1::image-occlusion:rect:left=.2496:top=.7065:width=.3893:height=.0855:oi=1}}
Published	02/16/2025	{{c1::image-occlusion:rect:left=.0022:top=.0064:width=.9899:height=.9905:oi=1}}
Published	02/16/2025	{{c1::image-occlusion:rect:left=.5116:top=.1846:width=.2634:height=.0817:oi=1}}{{c2::image-occlusion:rect:left=.5188:top=.3571:width=.2721:height=.081…
Published	02/16/2025	{{c1::image-occlusion:rect:left=.0073:top=.0078:width=.4836:height=.0497:oi=1}}{{c2::image-occlusion:rect:left=.3939:top=.936:width=.4685:height=.0405…
Published	02/16/2025	HPV Diagnostics● {{c1::Papanicolaou (Pap) Smear}}: For cervical cancer detection● {{c2::Cytological Test}}: Aims to detect precancerous cellular chang…
Published	02/16/2025	HPV Treatment{{c1::Removal of the lesion}} : SACEL● {{c2::Surgical excision}}● {{c2::Application of caustic agents}}● {{c2::Cryosurgery}}● {{c2::Elect…
Published	02/16/2025	HPV Prevention{{c1::Quadrivalent}} and {{c1::Bivalent}} HPV Vaccine● Contain virus-like particles composed of {{c2::HPV 11}} proteins
Published	02/16/2025	HPV Prevention2 Types of VaccineQUADRIVALENT: From HPV types {{c1::6,11,16, 18}}BIVALENT: From HPV types {{c1::16 and 18}}
Published	02/16/2025	{{c1::Human Papillomavirus}}● Most common type of STD around the world is {{c1::HumanPapillomavirus (HPV)}}● Naked Icosahedral symmetry● Double-strand…
Published	02/16/2025	{{c1::Herpes Simplex Virus}}● {{c2::DOUBLE}} stranded {{c2::LINEAR}} DNA molecules, replicate inthe {{c3::nucleus}}● Enveloped {{c4::ICOSAHEDRAL}}
Published	02/16/2025	{{c1::image-occlusion:rect:left=.0398:top=.4562:width=.1085:height=.1091:oi=1}}{{c2::image-occlusion:rect:left=.5145:top=.4562:width=.1056:height=.105…
Published	02/16/2025	{{c1::image-occlusion:rect:left=.0311:top=.4613:width=.0796:height=.0262:oi=1}}{{c2::image-occlusion:rect:left=.4609:top=.5208:width=.1462:height=.045…
Published	02/16/2025	{{c1::image-occlusion:rect:left=.7243:top=.6566:width=.2475:height=.0596:oi=1}}{{c2::image-occlusion:rect:left=.2554:top=.7329:width=.1838:height=.033…
Published	02/16/2025	{{c1::image-occlusion:rect:left=.2236:top=.543:width=.0738:height=.039:oi=1}}{{c2::image-occlusion:rect:left=.0326:top=.5109:width=.1563:height=.0665:…
Published	02/16/2025	{{c1::image-occlusion:rect:left=.5579:top=.7149:width=.1664:height=.0573:oi=1}}{{c2::image-occlusion:rect:left=.8155:top=.4673:width=.1462:height=.098…
Published	02/16/2025	{{c1::image-occlusion:rect:left=.2815:top=.2094:width=.1085:height=.0343:oi=1}}{{c2::image-occlusion:rect:left=.4421:top=.2489:width=.0593:height=.034…
Published	02/16/2025	{{c1::image-occlusion:rect:left=.1179:top=.4185:width=.2648:height=.0966:oi=1}}{{c2::image-occlusion:rect:left=.6216:top=.4145:width=.2793:height=.104…
Published	02/16/2025	{{c1::image-occlusion:rect:left=.1107:top=.7163:width=.3126:height=.1811:oi=1}}{{c2::image-occlusion:rect:left=.6172:top=.7284:width=.3488:height=.108…
Published	02/16/2025	{{c1::image-occlusion:rect:left=.7214:top=.2736:width=.259:height=.1087:oi=1}}
Published	02/16/2025	Because {{c1::latent}} infections do not require the synthesis of viral proteins, most antiviral drugs do not eradicate the virus when in its {{{c1::l…
Published	02/16/2025	{{c2::Reactivation}} of latent virus from ganglionic cells withsubsequent release of infectious virions accounts formost recurrent {{c1::genital infec…
Published	02/16/2025	Clinical FeaturesHSV Primary Infection● Incubation period {{c1::4 or 5 days}}● Can last about {{c2::3 weeks}}● Mild fever and malaise, with tender, us…
Published	02/16/2025	{{c1::image-occlusion:rect:left=.2448:top=.0686:width=.5348:height=.046}}{{c2::image-occlusion:rect:left=.2479:top=.1404:width=.3239:height=.0424}}{{c…
Published	02/16/2025	{{c1::Recurrent Genital Herpes}}● Shorter duration● Burning or prickly sensation in the pelvic area, that occur{{c2::12-24}} hours before the appearan…
Published	02/16/2025	{{c1::Neonatal}} Herpes● Transmission of the virus is during {{c3::delivery}}● Abnormal {{c2::nervous}} system● Disseminated vesicular lesions with wi…
Published	02/16/2025	Diagnostics of HSV● {{c1::PCR Test}}: - Most accurate and sensitive western blot assay for antibodies to HSV- Recommended for diagnosis of herpes meni…
Published	02/16/2025	HSV Treatment● {{c1::Acyclovir}}→ drug of choice● Several Antiviral drugs○ {{c2::Valacyclovir}}○ {{c2::Vidarabine}}
Published	02/16/2025	Herpes Simplex Virus● {{c1::Double}} stranded {{c1::linear}} DNA molecules → replicate in the nucleus● Enveloped {{c2::icosahedral}}● Symptoms  &…
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