Notes in (1.0) Introduction and Additives in Pharmaceutical Preparations (til Polymeric Flocculating Agents)

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Published 02/22/2024 A.O. no. 220 s. 1974
Published 02/22/2024 A.O. no. 43 s. 1999
Published 02/22/2024 A.O. no. 90 s. 2002
Published 02/22/2024 A.O. no. 55 s. 1988
Published 02/22/2024 A.O. no. 85 s. 1990
Published 02/22/2024 A.O. no. 99 s. 1990
Published 02/22/2024 R.A. 6675
Published 02/22/2024 R.A. 9502
Published 02/22/2024 A.O. no. 2008-0033
Published 02/22/2024 This solvent is widely used because of its physiological compatibility, lack of toxicity and high dielectric constant
Published 02/22/2024 Purified water is prepared by {{c1::distillation, ion-exchange, or reverse osmosis}}
Published 02/22/2024 Purified water is prepared by {{c1::distillation}}, {{c1::ion-exchange}}, or reverse osmosis
Published 02/22/2024 The impurities that can be gained from water are:{{c1::calciumironmagnesiumsilicasodium}}
Published 02/22/2024 The impurities that can be gained from water are:calciumiron{{c1::magnesium}}{{c1::silica}}{{c1::sodium}}
Published 02/22/2024 The approaches to improve aqueous solubility inculde:{{c1::CosolvencyControl of pHSolubilizationComplexationChemical modificationParticle size control…
Published 02/22/2024 The approaches to improve aqueous solubility inculde:{{c1::Cosolvency}}{{c1::Control of pH}}{{c2::Solubilization}}{{c2::Complexation}}{{c2::Chemical m…
Published 02/22/2024 The approaches to improve aqueous solubility inculde:{{c1::Cosolvency}}Control of pH{{c1::Solubilization}}{{c2::Complexation}}Chemical modification{{c…
Published 02/22/2024 {{c1::Cosolvency}} – alteration of the {{c2::polarity of solvent}} (decreasing the dielectric constant) by the addition of another solvent that is bot…
Published 02/22/2024 Cosolvency – alteration of the polarity of solvent (decreasing the {{c1::dielectric constant}}) by the {{c1::addition}} of another solvent that is bot…
Published 02/22/2024 Solubility of a weak base is increased by {{c1::decreasing}} the pH Solubility of weak acid is increased by {{c1::increasing}} the pH 
Published 02/22/2024 Solubility of a weak base is increased by {{c1::decreasing}} the pH Solubility of weak acid is increased by {{c2::increasing}} the pH 
Published 02/22/2024 Factors considered when setting the pH of a preparation: {{c1::Chemical stability}}bioavailabilitypreservative irritation{{c1::tissue damage}}
Published 02/22/2024 Factors considered when setting the pH of a preparation:{{c1::Chemical stabilitybioavailabilitypreservative irritationtissue damage}}
Published 02/22/2024 HLB values for solubilization by addition of a surfactant?
Published 02/22/2024 Methods under solubilization:Addition of {{c2::surfactant}} with HLB values of >15{{c4::Micellization}} {{c3::Spontaneous passage}} of poorly …
Published 02/22/2024 Methods under solubilization:Addition of surfactant with {{c1::HLB values of >15}}Micellization Spontaneous passage of poorly water soluble so…
Published 02/22/2024 Methods under solubilization:{{c1::Addition of surfactant with HLB values of >15Micellization Spontaneous passage of poorly water soluble solu…
Published 02/22/2024 Chemical modification may enhance solubility but may cause?
Published 02/22/2024 Solvent used in dimercaprol injection
Published 02/22/2024 Dimercaprol injection which uses a fixed oil as a solvent is used as an antidote for {{c1::heavy metal poisoning}}
Published 02/22/2024 Fixed Oils{{c1::Castor oil}} - miconazole eye drops and {{c1::triamcinolone}} ear dropsFractionated coconut oil - {{c1::antibiotics}}Arachis…
Published 02/22/2024 Olive oil, sesame oil, maize oil, soya oil are used for what dosage form?
Published 02/22/2024 TRUE OR FALSE: Non-volatile oils with fatty acid esters of glycerol are liquid at room temperature
Published 02/22/2024 TRUE OR FALSE: Non-volatile oils with fatty acid esters of glycerol can easily become rancid
Published 02/22/2024 Non-volatile oils with fatty acid esters of glycerol should not contain these:
Published 02/22/2024 TRUE OR FALSE: Non-volatile oils with fatty acid esters of glycerol aren't easily metabolized
Published 02/22/2024 TRUE OR FALSE: Isopropranol can be used externally and orally
Published 02/22/2024 Percentage limit of alcohol in oral otc products{{c1::0.5%}} – children under 6 years old  {{c2::5%}} – 6-12 yrs {{c3::10%}} – over 12 …
Published 02/22/2024 Percentage limit of alcohol in oral otc products{{c1::0.5%}} – children under 6 years old  {{c1::5%}} – 6-12 yrs {{c1::10%}} – over 12 …
Published 02/22/2024 Percentage limit of alcohol in oral otc products0.5% – children under 6 years old  5% – {{c1::6-12 yrs }}10% – over {{c1::12 yrs}}
Published 02/22/2024 TRUE OR FALSE: Alcohol can be used as a preservative with other known preservatives
Published 02/22/2024 Glycerol is aka
Published 02/22/2024 Percentage of alcohol used as a preservative in conjuction with other preservatives:15% (w/w) for  {{c1::acid }}18% (w/w) for {{c1::base}}
Published 02/22/2024 Percentage of alcohol used as a preservative in conjuction with other preservatives:{{c1::15% (w/w)}} for acid{{c1::18% (w/w)}} for base
Published 02/22/2024 Characteristics of Glycerol:{{c1::Clear,}} syrupy liquid, with {{c1::sweet}} taste Miscible with {{c1::water and alcohol}}
Published 02/22/2024 Characteristics of Glycerol:{{c1::Clear, syrupy liquid, with sweet taste Miscible with water and alcohol}}
Published 02/22/2024 Use of glycerol for topical preparations
Published 02/22/2024 Glycerol can be an antimicrobial preservative at a concentration of {{c1::20-30%}}
Published 02/22/2024 Uses of glycerol in parenterals and oral solutions:{{c1::solventsweetening agentantimicrobial preservative viscosity enhancer}}
Published 02/22/2024 Uses of glycerol in parenterals and oral solutions:solvent{{c1::sweetening agent}}antimicrobial preservative {{c1::viscosity enhancer}}
Published 02/22/2024 TRUE OR FALSE: Propylene Glycol is immiscible with alcohol
Published 02/22/2024 Solvent used in place of glycerin
Published 02/22/2024 At what concentration is propylene glycol considered as an antiseptic?
Published 02/22/2024 TRUE OR FALSE: Propylene glycol is less effective than ethanol with repsect to antiseptic properties
Published 02/22/2024 Propylene glycol is a carrier for {{c1::emulsifiers}}, vehicle for flavors
Published 02/22/2024 Mineral oil is aka
Published 02/22/2024 Adverse effect of using Liquid paraffin
Published 02/22/2024 Other solvents uses:Isopropyl myristate and isopropyl {{c1::palmitate}} – solvents for cosmetics Xylene – for {{c1::eardrops}} to dissolve earwax…
Published 02/22/2024 Propylene glycol — Viscous fluid; miscible with {{c1::water}} and {{c1::alcohol}}
Published 02/22/2024 Used as a Solvent in place of glycerin
Published 02/22/2024 Non-aqueous solvent that aids in the penetration of drugs through the skin
Published 02/22/2024 Added to resist change in the pH of the preparation
Published 02/22/2024 Most hydrolysable drugs will have optimum stability between pH {{c1::5}} and {{c1::6}}
Published 02/22/2024 Optimum pH of the following dosage forms:Injection: pH {{c1::3-9 }}Nasal: pH {{c1::5.5-6.5 }}Ophthalmic: pH {{c1::7.4 }}Vaginal: pH {{c…
Published 02/22/2024 Optimum pH of the following dosage forms:Injection: pH {{c2::3-9 }}Nasal: pH {{c1::5.5-6.5 }}Ophthalmic: pH {{c2::7.4 }}Vaginal: pH {{c…
Published 02/22/2024 Provide electrons and easily available hydrogen atoms that are accepted more readily by the free radicals
Published 02/22/2024 Enumerate antioxidants for aqueous solutions:{{c1::Sulfites}}{{c1::hydrophosphorous acids}}{{c1::ascorbic acid}}
Published 02/22/2024 Enumerate antioxidants for aqueous solutions:{{c2::Sulfites}}{{c1::hydrophosphorous acids}}{{c2::ascorbic acid}}
Published 02/22/2024 Enumerate the antioxidants for oleaginous preparations{{c1::BHT}}{{c1::BHA}}{{c1::alpha-tocopherols}}{{c1::ascorbyl palmitate}}
Published 02/22/2024 Enumerate the antioxidants for oleaginous preparations{{c2::BHT}}{{c1::BHA}}{{c1::alpha-tocopherols}}{{c2::ascorbyl palmitate}}
Published 02/22/2024 Complex or bind the metals to make them unavailable for participation in the oxidative process
Published 02/22/2024 Agent used to prevent the growth of microorganisms
Published 02/22/2024 Enumerate Acidic Preservatives:{{c1::Phenol}}{{c1::Alkyl esters of phydroxybenzoic acid (Parabens)}}{{c1::Benzoic acid and its salt}}{{c1::Sorbic acid…
Published 02/22/2024 Enumerate Acidic Preservatives:{{c1::Phenol}}{{c2::Alkyl esters of phydroxybenzoic acid (Parabens)}}{{c2::Benzoic acid and its salt}}{{c1::Sorbic acid…
Published 02/22/2024 Characteristics of acidic preservatives:Phenol — {{c1::Antimicrobial}}Parabens — {{c1::Antifungal}}Benzoic Acid — {{c1::Antifungal}}Sorbic Acid — {{c1…
Published 02/22/2024 Characteristics of acidic preservatives:Phenol — {{c2::Antimicrobial}}Parabens — {{c1::Antifungal}}Benzoic Acid — {{c1::Antifungal}}Sorbic Acid — {{c2…
Published 02/22/2024 Netutral preservatives:{{c1::Chlorobutanol}}{{c1::Benzyl alcohol}}
Published 02/22/2024 Netutral preservatives:Chlorobutanol — {{c1:: Lytic and denaturation action on membranes}}Benzyl alcohol — {{c1:: Lytic and denaturation act…
Published 02/22/2024 Netutral preservatives:Chlorobutanol — {{c1:: Lytic and denaturation action on membranes}}Benzyl alcohol — {{c2:: Lytic and denaturation act…
Published 02/22/2024 Enumerate Mercurial preservatives (2):{{c1::thimerosalnitromersol}}
Published 02/22/2024 Enumerate Quaternary ammonium compounds preservatives:{{c1::Benzalkonium chlorideCetylpyridinium chloride}}
Published 02/22/2024 Preservatives commonly used in parenteral preparations:{{c1::Benzyl alcohol}}{{c1::Parabens}}{{c1::sodium metasulphite}}{{c1::sodium bisulphite}}
Published 02/22/2024 Preservatives commonly used in parenteral preparations:{{c1::Benzyl alcohol}}{{c2::Parabens}}{{c1::sodium metasulphite}}{{c2::sodium bisulphite}}
Published 02/22/2024 Preservatives commonly used in Ophthalmic preparations:{{c1::Benzalkonium chloride}}thimerosalparabens{{c1::Benzalkonium chloride + EDTA}}
Published 02/22/2024 Preservatives commonly used in oral preparations:{{c1::Sodium benzoate}}{{c2::parabens}}
Published 02/22/2024 Preservatives commonly used in creams preparations:{{c1::Benzyl alcohol}}ParabensBenzoic{{c1::Sorbic acid}}
Published 02/22/2024 Preservatives commonly used in creams preparations:{{c1::Benzyl alcohol}}{{c2::Parabens}}{{c1::Benzoic}}Sorbic acid
Published 02/22/2024 {{c1::image-occlusion:rect:left=.4171:top=.4727:width=.1639:height=.0439:oi=1}}{{c2::image-occlusion:rect:left=.6058:top=.2008:width=.1509:height=.082…
Published 02/22/2024 {{c1::image-occlusion:rect:left=.3443:top=.8843:width=.1182:height=.0519:oi=1}}{{c2::image-occlusion:rect:left=.5858:top=.8866:width=.1499:height=.058…
Published 02/22/2024 Two kinds of colorants:
Published 02/22/2024 This kind of colorant exhibit color of transmitting light, should be used at the lowest concentration in the dull color
Published 02/22/2024 Things to consider in the formulation of suspension (4): {{c1::Particle size control Use of wetting agent Flocculated and deflocculated&nbsp…
Published 02/22/2024 Things to consider in the formulation of suspension (4):{{c1::Particle size control }}{{c1::Use of wetting agent }}{{c2::Flocculated and defloccu…
Published 02/22/2024 Things to consider in the formulation of suspension (4):{{c1::Particle size control }}{{c2::Use of wetting agent }}{{c1::Flocculated and defloccu…
Published 02/22/2024 Enumerate External Surfactants:SLS{{c1::sodium dioctylsulfosuccinate}}{{c1::quillaia}} extract;
Published 02/22/2024 Enumerate External Surfactants:{{c1::SLS}}{{c1::sodium dioctylsulfosuccinate}}{{c1::quillaia extract;}}
Published 02/22/2024 Enumerate Parenteral Surfactants:{{c1::polysorbates}}{{c1::poloxamers}}{{c1::lecithin}}
Published 02/22/2024 Enumerate Parenteral Surfactants:{{c2::polysorbates}}{{c1::poloxamers}}{{c2::lecithin}}
Published 02/22/2024 Disadvantages of surfactants:excessive foaming,formation of {{c1::deflocculated}} system
Published 02/22/2024 Pharmaceutical agent used to decrease interfacial tension
Published 02/22/2024 These are protective colloids by coating the solid hydrophobic particles with a multimolecular layer
Published 02/22/2024 These may be used as suspending agent; produce deflocculated system at low concentrations
Published 02/22/2024 Enumerate examples of hydrophobic colloids (6):{{c1::Acaciabentonite tragacanthalginatesxanthan gumcellulose derivatives}}
Published 02/22/2024 Enumerate examples of hydrophobic colloids (6):{{c1::Acacia}}bentonite tragacanth{{c1::alginates}}{{c1::xanthan gum}}cellulose derivatives
Published 02/22/2024 Enumerate examples of hydrophobic colloids (6):Acacia{{c1::bentonite}}{{c1::tragacanth}}alginatesxanthan gum{{c1::cellulose derivatives}}
Published 02/22/2024 These are used to prevent clumping of solid insoluble substances
Published 02/22/2024 Electrolytes are use to alter {{c1::zeta}} potential
Published 02/22/2024 {{c1::Trivalent}} ions are more effective but more {{c1::toxic}} and may be precipitated if {{c1::hydrophilic polymers}} are in the formulation
Published 02/22/2024 Monovalent/divalent ions examples: {{c1::sodium salts of acetates, phosphates, citrates (now preferred)}}
Published 02/22/2024 Preferred electrolyte
Published 02/22/2024 {{c1::image-occlusion:rect:left=.1449:top=.3195:width=.1245:height=.0607:oi=1}}{{c2::image-occlusion:rect:left=.7624:top=.2564:width=.0788:height=.051…
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