Notes in Nucleotide Metabolism

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Published	08/28/2024	What are pyrimidine rings made out of?{{c1::Bicarbonate}}, {{c1::aspartate}}, {{c1::NH4+ (FROM GLUTAMINE)}} via {{c1::CPSII (carbamoyl …
Published	08/28/2024	After the pyrimidine ring is made, + w/ {{c1::PRPP}} (A ribose phosphate) --> {{c2::UTP}} via {{c2::PRPP synthetase}}
Published	08/28/2024	What is the committed (and therefore regulated) step of pyrimidine synthesis?Actually making the ring with {{c1::ATCase}}
Published	08/28/2024	How can you make different ribonucleotides (i.e, make a pyrimidine vs a purine)?Use a different {{c1::Phosphoribosyl Transferase}}
Published	08/28/2024	How can you regulate synthesis of Pyrimidines?^ synthesis w/ {{c1::ATP}}v synthesis w/ {{c1::CTP}} (an end-product of pyrimidine synthesis)
Published	08/28/2024	What is the source of carbons for Purines?Mostly {{c1::AAs}}Synthesis starts with a {{c1::ribose-P ring}}
Published	08/28/2024	What is the committed step of Purine synthesis?NH3 (from Gln) + PRPP via {{c1::Glutamine phosphoribosyl transferase}}.v enzyme activity w/ {…
Published	08/28/2024	What enzymes are essential to making pyrimidines?{{c1::Orotate PhosphoribosylTransferase}}{{c1::CPS II (carbamoyl phosphate synthetase II)}}…
Published	08/28/2024	What enzyme is essential to making purines?{{c1::Glutamine phosphoribosyl transferase}}
Published	08/28/2024	When making purines, a couple steps use {{c1::GTP}}
Published	08/28/2024	How can you regulate which branch, at bottom, is favored?{{c1::GMP}} decreases IMP flowing to GTP{{c1::AMP}} decreases IMP flowing to ATPTheme: If you…
Published	08/28/2024	What is a salvage pathway?Making new / different products from the skeletons of your brother molecules.{{c1::Purines::Purines/Pyrimidines}} can be mad…
Published	08/28/2024	What enzymes are used in Purine Salvage Pathway?{{c1::Ribonucleotide reductase}}{{c1::Adenine Phosphoribosyltransferase}} --> another one of those!…
Published	08/28/2024	Ribonucleotide reductase makes ribonucleotides --> deoxyribonucleotides.Its {{c1::Activity Site}} turns it on/off, --\|ed by {{c1::dATP}}I…
Published	08/28/2024	When ribonucleotide reductase binds {{c1::purine nucleotides}}, it makes {{c1::pyrimidine nucleotides}} and vice versa.Keeps the {{c1::balance :)…
Published	08/28/2024	What molecular rxns are an important target for chemotherapeutic drugs?dUMP --> dTMP via {{c1::Thymidylate synthase}}Also dihydrofolate -…
Published	08/28/2024	What chemotherapeutic drugs inhibit dUMP-->dTMP and dihydrofolate-->tetrahydrofolate?dUMP --> dTMP = {{c1::Fluorouracil}}Dihydrofolate -…
Published	08/28/2024	What is the product of breaking down Purines?{{c1::Uric Acid / Urate}}
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