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Published	10/21/2024	Glucocorticoid synthesis inhibitors and antagonists are used for excess production of steroids like in {{c1::Cushing's Syndrome}}
Published	10/21/2024	Hormones are synthesized from cholesterol→ Pregnenolone produces {{c1::Cortisol}}→ Progesterone produces {{c2::Aldosterone}}→ Dehydroepiandrosterone p…
Published	10/21/2024	Glucocorticoid antagonists affect specific parts of this pathway to{{c1::inhibit}} hormone production
Published	10/21/2024	{{c1::image-occlusion:rect:left=.5976:top=.5125:width=.1542:height=.05:oi=1}}
Published	10/21/2024	{{c1::image-occlusion:rect:left=.0947:top=.734:width=.1196:height=.0313:oi=1}}
Published	10/21/2024	{{c1::image-occlusion:rect:left=.5343:top=.6479:width=.1039:height=.0344:oi=1}}
Published	10/21/2024	{{c1::image-occlusion:rect:left=.3185:top=.8076:width=.1227:height=.0406:oi=1}}
Published	10/21/2024	{{c1::image-occlusion:rect:left=.1842:top=.4318:width=.2109:height=.0625:oi=1}}
Published	10/21/2024	Aminoglutethimide● Site of action:→ Blocks conversion of cholesterol to {{c1::pregnenolone}}
Published	10/21/2024	{{c1::Aminoglutethimide}} causes reduction of synthesis of all hormonally active steroids
Published	10/21/2024	Aminoglutethimide● Clinical application→ Reduce steroid secretion in {{c1::Cushing’s syndrome}}
Published	10/21/2024	Adverse effects of aminogluthimide
Published	10/21/2024	Adverse effects of Aminoglutethimide→ Cortisol insufficiency{{c1::→ Pancytopenia}}→ Pruritus→ Leukopenia{{c1::→ Agranulocytosis}}→ Neutropenia→ N…
Published	10/21/2024	{{c1::Aminoglutethimide}} is the most potent since it cuts off the pathwaysfor the production of other components
Published	10/21/2024	Metyrapone● Site of action:→ Blocks conversion of {{c1::11-deoxycortisol}} to cortisol
Published	10/21/2024	Selective inhibitor of steroid 11-hydroxylation, interfering withcortisol and corticosterone synthesis
Published	10/21/2024	Metyrapone● Clinical application:→ Diagnostic evaluation of {{c1::HPAA (Hypothalamic-pituitary-adrenal axis)}}
Published	10/21/2024	Only antagonist that can be administered to pregnant women withCushing's syndrome
Published	10/21/2024	Metyrapone Adverse effects:→ Cortisol insufficiency→ {{c1::Hypertension}}→ {{c2::Salt and water retention and hirsutism}}
Published	10/21/2024	Trilostane● Site of action:→ Blocks conversion of:▪ Pregnenolone to {{c2::progesterone}} (cortisol & aldosterone synthesis)▪ 17-hydroxyprogesteron…
Published	10/21/2024	Clinical application of Trilostane→ Cushing’s syndrome in {{c1::dogs}}
Published	10/21/2024	Adverse effects of Trilostane
Published	10/21/2024	Mitotane● Site of action:→ Nonselective cytotoxic action on the {{c1::adrenal cortex}} in dogs and to a lesser extent in humans
Published	10/21/2024	Clinical application: Mitotane→ Medical {{c1::adrenalectomy}} in cases of severe Cushing's syndrome oradrenocortical CA
Published	10/21/2024	Adverse effects: Mitotane→ Visual disturbance{{c1::→ Hemorrhagic cystitis}}→ Hypercholesterolemia{{c2::→ Somnolence}}→ Nausea→ Depression
Published	10/21/2024	Ketoconazole● Site of action:→ Blocks conversion of 17-hydroxypregnenolone to {{c1::Dehydroepiandrosterone}}
Published	10/21/2024	Ketoconazole clinical application:→ {{c2::Cushing's Syndrome}}→ Antifungal {{c1::imidazole}} derivative
Published	10/21/2024	Ketoconazole elevates {{c1::liver enzymes}} as its side effect.
Published	10/21/2024	Mifepristone● Site of action:→ Pharmacologic antagonist at the steroid receptor▪ Unlike other antagonists that inhibit enzymes, this blocks the{{c1::g…
Published	10/21/2024	MifepristoneClinical application:→ Abortion (through {{c2::Day 49 or pregnancy}})▪ {{c1::Cytotec}}: no longer available in the market
Published	10/21/2024	Mifepristone Adverse effects:→ Headache→ Abnormal vaginal bleeding{{c2::→ Nausea}}→ Diarrhea→ Sepsis→ Vomiting→ Cramps{{c1::→ Bacterial infections}}→ …
Status	Last Update	Fields