Notes in D.4. Peripheral B-Cell Neoplasms - Diffuse Large B-cell Lymphoma to Hairy Cell Leukemia

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Published	10/21/2024	This neoplasm is characterized by the ff cellular morphoplogy:Cell size: Large (usually four to five times the diameter of a small lymphocyte) Pa…
Published	10/21/2024	In diffuse large B-cell lymphoma, this expresses CD19 and CD20 and is responsible for a more aggressive behavior.
Published	10/21/2024	3 characteristics of Immunophenotype that give it its aggressive behavior
Published	10/21/2024	Give the 2 Special subtypes of Diffuse large B-cell lymphoma.
Published	10/21/2024	Special subtype of Diffuse large B-cell lymphoma:▪ Occurs in the setting of T-cell immunodeficiency▪ The neoplastic B cells are usually infected …
Published	10/21/2024	In Immunodeficiency-associated large B-cell lymphoma, what causes the regression of the neoplastic proliferations?
Published	10/21/2024	Special Subtype of Diffuse large B-cell lymphoma:▪ Malignant pleural or ascitic effusion, mostly in patients withadvanced HIV or in older adults▪…
Published	10/21/2024	What is responsible for the anaplastic appearance of tumor cells in Primary effusion lymphoma?
Published	10/21/2024	Primary effusion lymphoma commonly affects older individuals and patients with advanced HIV, what is the virus that infects the tumor cells?
Published	10/21/2024	This neoplasm presents with the ff clinical features:→ Rapidly enlarging mass at a nodal or extranodal site→ Can arise virtually anywhere in the body;…
Published	10/21/2024	These are lymphoid tissue of the nasopharynx, palatine tonsils, base of tongue, and soft palate that screens and filters exog…
Published	10/21/2024	What improves both the initial response and the overall outcome in Diffuse large B-cell lymphoma?
Published	10/21/2024	In Diffuse large B-cell lymphoma, translocations in which transcription factor (oncogene) have a worse prognosis?
Published	10/21/2024	In the pathogenesis of Diffuse Large B-Cell Lymphoma, what is the a DNA-binding zinc finger transcriptional repressor thatis required for the for…
Published	10/21/2024	In Diffuse Large B-cell Lymphoma, tumors with BCL2 rearrangement usually lacks ____  rearrangements.
Published	10/21/2024	Immunophenotype in Diffuse large B-cell lymphoma→ Those cells with high levels of _____ and _____ are highlyaggressive.
Published	10/21/2024	Give the virus responsible for the ff special subtypes:a. Immunodeficiency-associated lymphomab. Primary effusion lymphoma -
Published	10/21/2024	Give the most notable clinical feature of Diffuse large B-cell lymphoma.
Published	10/21/2024	A subset of aggressive lymphomas occurring in individuals infectedwith HIV
Published	10/21/2024	Pathogenesis of Burkitt Lymphoma→ All forms are associated with translocations of the ___ gene onchromosome 8 that lead to increased MYC protein level…
Published	10/21/2024	Pathogenesis of Burkitt Lymphoma→ All forms are associated with translocations of the MYC gene onchromosome __ that lead to increased MYC protein leve…
Published	10/21/2024	Pathogenesis of Burkitt Lymphoma→ All forms are associated with translocations of the MYC gene onchromosome 8 that lead to (increased or decreased)&nb…
Published	10/21/2024	Pathogenesis of Burkitt Lymphoma→ MYC increases the expression of genes that are required forwhat biological process?
Published	10/21/2024	Pathogenesis of Burkitt Lymphoma→ All forms are associated with translocations of the a. ___ gene onchromosome __ that lead to (increased/ decreased)&…
Published	10/21/2024	This is among the fastest-growing human tumors.
Published	10/21/2024	Pathogenesis of Burkitt Lymphoma:→ Sequencing of the genomes revealed mutations that increase theactivity of the transcription factor _____, an i…
Published	10/21/2024	Essentially all endemic Burkitt lymphomas are latently infectedwith which virus?
Published	10/21/2024	Which lymphoid neoplasm is morphologically described below:→ Involved tissues are effaced by a diffuse infiltrate ofintermediate-sized lymphoid cells …
Published	10/21/2024	What morphological features are seen in the image A and B. Identify the lymphoid neoplasm associated with them.
Published	10/21/2024	A process that uses antibodies to identify cells based on the types of antigens or markers on the surface of the cells. This process is used in basic …
Published	10/21/2024	Give the immunophenotype used for Burkitt Lymphoma
Published	10/21/2024	At which sites in the body does Burkitt lymphoma usually manifests?
Published	10/21/2024	A (specific) type of neoplastic lymphoma with mass involving the mandible and shows an unusual predilection for involvement of abdominal vis…
Published	10/21/2024	A (specific) type of neoplastic lymphoma with mass involving the ileocecum and peritoneum.Sporadic Burkitt lymphoma
Published	10/21/2024	Which oncogene/transcription factor is known at the master translocational regulator that increases the expression of genes required for aerobic glyco…
Published	10/21/2024	An uncommon lymphoid carcinoma occuring at 5th to 6th decades of life with a male predominance.
Published	10/21/2024	Tumor cells of this lymphoid neoplasm closely resemble the normal mantle zone B cells that surround the germinal center.
Published	10/21/2024	Pathogenesis of Mantle Cell Lymphoma:→ (11;14) translocation involving the IGH locus on chromosomea. ___ and the cyclin D1 locus on chromosome b.___ t…
Published	10/21/2024	Pathogenesis of Mantle Cell LymphomaUpregulation of cyclin D1 promotes G1-to-S-phase (progression or regression?) during the cell cycle.
Published	10/21/2024	Which lymphoid neoplasm has the ff clinical descriptions:→ At diagnosis, majority have generalized lymphadenopathy (LAD)→ Mucosal involvement of the s…
Published	10/21/2024	Mucosal involvement of the small bowel or colon producespolyp-like lesion. This is referred to as?
Published	10/21/2024	Microscopic morphology of mantle cell lymphoma:proliferation consists of a homogenous populationof small lymphocytes with irregular to occasionally de…
Published	10/21/2024	Give the immunophenotypes of mantle cell lymphoma:
Published	10/21/2024	Clinical features of Mantle Cell Lymphoma
Published	10/21/2024	Median length of survival of patients with Mantle Cell Lymphoma in years
Published	10/21/2024	A type of lymphoid neoplasm which encompasses a heterogeneous group of B-cell tumors that arise within lymph nodes, spleen, or extranod…
Published	10/21/2024	In Marginal Zone lymphoma, the extranodal tumors were initially recognized at mucosal sites and are often referred to as __________.
Published	10/21/2024	Tumor cells of marginal zone lymphoma show evidence of what mutation in the V-region of both heavy and light chains in most cases?
Published	10/21/2024	Which lymphoid neoplasm is characterized below:→ Often arise within tissues involved by chronic inflammatory disorders of autoimmune or infectious eti…
Published	10/21/2024	Different ypes of these lymphoid neoplasm share the same features however those that occur in extranodal sites require special attention. Autoimmune o…
Published	10/21/2024	A rare lymphoid neoplasm predominantly affecting middle-aged white males, with a median age of 55 and a male-to-female ratio of 5:1
Published	10/21/2024	Pathogenesis:→ Associated in more than 90% of cases with activating point mutations in the serine/threonine kinase BRAF, which liesimmediately downstr…
Published	10/21/2024	Hairy Cell Leukemia Pathogenesis:→ Associated in more than 90% of cases with activating pointmutations in the ___________________________, which liesi…
Published	10/21/2024	Hairy Cell Leukemia Pathogenesis:→ Specific mutation is the substitution of which amino acid to glutamate at residue 600?
Published	10/21/2024	Morphology of this lymphoid neoplasm:→ Leukemic cells have fine, hair-like projections that are bestrecognized under the phase contrast microscope→ On…
Published	10/21/2024	Which lymphoid neoplasm has the ff phenotypes:→ Express pan-B-cell markers CD19 and CD2→ Express surface Ig (usually IgG)→ Express CD11t, CD25, CD103,…
Published	10/21/2024	Has the ff clinical features:→ Clinical manifestations result largely from infiltration of the bonemarrow, liver, and spleen→ LAD (Lymphadenopathy) is…
Published	10/21/2024	Specific mutation or the substitution of valine to glutamate atresidue 600 in Hairy Cell leukemia is also found in high frequencies of neoplasms. Iden…
Published	10/21/2024	What is the most common and sometimes the only abnormal physical finding in patients with hairy cell leukemia?
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