Notes in 01_Gout

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Published	02/10/2024	Crystal Deposition Diseases include: {{c1::Gout (Monosodium urate)}} {{c1::Pseudogout (Calcium Pyrophosphate Dihydrate - CPPD)}} {{c1::Calcific Peria…
Published	02/10/2024	{{c1::Gout}} is a type of crystal arthropathy associated with chronically high blood {{c2::uric acid}} levels causing {{c2::urate crystals}}…
Published	02/10/2024	Presentation of Gout {{c1::Gouty Tophi Subcutaneous deposition of uric acid. DIP joints in hands are the most affected}} {{c1::Acute flares Single…
Published	02/10/2024	Differential Diagnosis of Gout{{c1::Septic arthritis}}
Published	02/10/2024	Purine metabolism and GoutIn the vast majority of people with gout, {{c1::hyperuricaemia}} results from reduced efficiency of {{c2::renal urate cleara…
Published	02/10/2024	How does Alcohol increase risk of Gout?[1] {{c1::The metabolism of ethanol to Acetyl CoA leads to adenine nucleotide degradation, resulting in increas…
Published	02/10/2024	Overproduction causes of Hyperuricaemia {{c1::Malignancy e.g lymphoproliferative, tumour lysis syndrome}} {{c1::Severe exfoliative psoriasis}} {{c1::D…
Published	02/10/2024	Under-excretion causes of Hyperuricaemia {{c1::Renal impairment}} {{c1::Hypertension}} {{c1::Hypothyroidism}} {{c1::Drugs e.g. alcohol, low dose aspir…
Published	02/10/2024	Pseudogout vs GoutJoints affected{{c1::Larger proximal}} ‒ {{c1::1st MTPJ}}Crystal type{{c1::Calcium pyrophosphate crystals}} ‒ {{c1::Sodium urate cry…
Published	02/10/2024	Investigations of Gout {{c1::Aspiration of fluid from joint Serum urate Negatively birefringent (yellow crystals under parallel light)}} {{c1::X-ra…
Published	02/10/2024	Management of Acute flares of Gout{{c1::NSAIDs}}{{c1::Colchicine}}{{c1::Steroids}}
Published	02/10/2024	{{c1::Colchicine}} is used in Gout patients that are inappropriate for NSAIDs, such as those with renal impairment or significant heart disease. A not…
Published	02/10/2024	Plan for Management of Hyperuricaemia {{c1::Does it NEED to be treated?}} {{c1::1st attack is not treated unless: Single attack of polyarticular gout…
Published	02/10/2024	Medications used for Management of Hyperuricaemia {{c1::Xanthine oxidase inhibitor e.g. Allopurinol}} {{c1::Febuxostat}} {{c1::Uricosuric agents e.g. …
Published	02/10/2024	Rules for lowering Uric acid levels {{c1::Wait until the acute attack has settled before attempting to reduce the urate level}} {{c1::Use prophylactic…
Published	02/10/2024	First-line for Management of {{c2::Hyperuricaemia}} is {{c1::Xanthine oxidase inhibitor e.g. Allopurinol}}
Published	02/10/2024	Lifestyle Changes for Management of Gout {{c1::Losing weight}} {{c1::Staying hydrated}} {{c1::Minimise consumption of alcohol}} {{c1::Minimise purine-…
Published	02/10/2024	Do not initiate {{c1::allopurinol}} prophylaxis to treat Hyperuricaemia until after the acute attack of Gout is settled
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