Notes in PHARM 111-01

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Published	09/15/2023	Review (Q1): {{c1::Membane potential}} is the {{c2::difference in electric potential between the cytoplasm and the extracellular space}}. {{…
Published	09/17/2023	Q1: {{c1::Currents }}are caused by the {{c2::movement of charges (change in potential).}} The convention is that {{c3::those charges are pos…
Published	09/15/2023	Q1: {{c1::Inwardly rectifying currents}} are {{c2::currents flowing into cells, aka negative currents}}.E.g. Na+ flowing into the cell.Currents refer …
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Published	09/15/2023	Q1: {{c1::Outwardly rectifying currents}} are {{c2::currents flowing out of cells, aka positive currents}}.E.g. K+ flowing out of the cell.Currents re…
Published	09/15/2023	{{c1::Voltage (V)}} is {{c2::energy per unit of charge}}
Published	09/15/2023	A {{c1::capacitor}} is a {{c2::device that can store electrical energy}}It does so by {{c3::keeping charges separate, due to creating/keeping el…
Published	09/15/2023	{{c1::Capacitance}} is a {{c2::measure of how many charges per unit of potential can be stored in a capacitor}}
Published	09/15/2023	A {{c1::resistor}} is a device that {{c2::allows the passage (conductions) of charges}}
Published	09/15/2023	{{c1::Conductance (G)}} is a measure of {{c2::how much charge flow (current) per unit of potential}}Equation: {{c3::G = 1/R}}
Published	09/15/2023	Examples of resistors (2)
Published	09/15/2023	Example of Capacitor
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Published	09/15/2023	{{c1::Biological membranes}} contain {{c2::at least one battery}} which functions as {{c3::the energy source for charge flow (i.e. current).}}Each {{c…
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Published	09/15/2023	Ohm's Law states that {{c1::current}} is equal to {{c2::voltage/resistance}}The higher the {{c3::resistance}}, the {{c4::more energy is needed to move…
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Published	09/15/2023	Q4: What do NaV channels consist of? How do they work?
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Published	09/15/2023	Q4: How do NaV channels work (explain with superdomains)?
Published	09/15/2023	{{c1::Phenytoin}}is a drug that is regarded as a {{c2::Na+ channel blocker}}. However, the mechanism of action of this drug {{c3::entails the stabiliz…
Published	09/15/2023	In general, action potentials (AP) are regarded as self-regenerative, all-or-nothing, stereotypic electrical responses in excitable cells. This idea i…
Published	09/15/2023	APs in the soma or in the presynaptic terminal of a neuron can display {{c1::distinct/different}} temporal profiles.
Published	09/15/2023	The {{c1::differential expression pattern of ion channels and other proteins}} within a neuron {{c2::determines the distinct temporal shape of AP in e…
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Published	09/15/2023	265fee7ef18541cfbd28cac424e53c4b-oa-1
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