Notes in Case 2: Parkinson's

To Subscribe, use this Key

Status	Last Update	Fields
Published	05/11/2024	Stimulation of the {{c1::mesolimbic}} dopamine pathway results in increased addiction behaviors in people taking levodop…
Published	05/11/2024	Stimulation of the {{c1::mesocortical}} dopamine pathway results in increased hallucinations and nightmares in people ta…
Published	05/11/2024	Head tremor = {{c1::Essential}} tremor, not Parkinson's
Published	05/11/2024	The cardinal feature of Parkinson's disease is {{c1::bradykinesia}}
Published	05/11/2024	Parkinson's is associated with {{c1::resting}} tremor
Published	05/11/2024	Parkinson's is associated with "{{c1::stooped}}" posture
Published	05/11/2024	Stimulation of the {{c1::nigrostriatal}} dopamine pathway results in decreased {{c2::bradykinesia}} and {{c2::rigidity}}…
Published	05/11/2024	In the US, levodopa is always paired with {{c1::carbidopa}}
Published	05/11/2024	{{c1::Lewy Body Dementia}} and {{c2::Multiple System Atrophy}} are Parkinson's plus syndromes that are characterized by accumulation of {{c3::synuclei…
Published	05/11/2024	Parkinson's plus syndromes that are characterized by the accumulation of {{c1::synuclein}} are more responsive to levodopa than those characteriz…
Published	05/11/2024	Parkinson's plus syndromes are somewhat responsive to {{c1::levodopa::drug(s)}} but not at all to {{c1::dopamine agonists::drug(s)}}
Published	05/11/2024	Both MAO-B inhibitors and COMT inhibitors extend the half-life of levodopa, but {{c1::MAO-B}} inhibitors can also be used standalone in early Par…
Published	05/11/2024	The picture below shows {{c1::Lewy bodies::what histological feature}}
Published	05/11/2024	Which antipsychotic is preferentially used to treat psychotic symptoms in Parkinson's disease with dementia?{{c1::Quetiapine}}
Published	05/11/2024	Early-onset dementia with Parkinsonian features is suggestive of {{c1::Lewy body}} dementia
Published	05/11/2024	{{c1::Levodopa (L-DOPA)}} is a precursor of dopamine that does cross the blood-brain barrier
Published	05/11/2024	Once in the CNS, L-DOPA may be converted to {{c2::dopamine}} via the enzyme {{c1::DOPA decarboxylase}}
Published	05/11/2024	{{c1::Carbidopa}} is a peripheral {{c2::DOPA decarboxylase}} inhibitor used to increase the bioavailability of levodopa
Published	05/11/2024	Dopamine in the CNS may be degraded to {{c2::3-methoxytyramine (3-MT)}} via the enzyme {{c1::catechol-O-methyltransferase (COMT)}}
Published	05/11/2024	{{c2::Entacapone}} is a peripheral {{c1::COMT}} inhibitor used to increase the bioavailability of levodopa
Published	05/11/2024	Dopamine in the CNS may be degraded to {{c2::DOPAC}} via the enzyme {{c1::MAO-B}}
Published	05/11/2024	{{c2::Ropinirole}} is a non-ergot {{c1::D2}} receptor agonist that is used in initial treatment of Parkinson disease
Published	05/11/2024	Dopamine receptor agonists, such as ropinirole, may {{c1::increase}} impulse activities (e.g. gambling, shopping, hypersexuality)
Published	05/11/2024	What form of parkinsonism presents with rapidly progressive gait dysfunction, falls, executive function loss, and vertical gaze palsy?{{c1::Progressiv…
Published	05/11/2024	{{c1::Multiple system atrophy (MSA)::What condition?}} involves 2/3 of:{{c2::Motor abnormalities (Parkinsonian)::M}} {{c2::"S"erebellar (cerebell…
Published	05/11/2024	What is the treatment of choice for Parkinson disease patients that are non-functional OR over 70 years old?{{c1::Carbidopa-levodopa}}
Published	05/11/2024	When levodopa/carbidopa starts to wear off for Parkinson disease, add:{{c1::MAO-B inhibitors (selegiline)::drug class}}{{c2::COMT inhibitors (-capone)…
Published	05/11/2024	REM sleep behavior disorder is associated with {{c1::alpha-synuclein}} neurodegenerative disorders
Published	05/11/2024	Which Parkinson's disease plus syndrome includes bradykinesia with vertical gaze palsy, apathy, and postural instability?{{c1::Progressive supranuclea…
Status	Last Update	Fields