Notes in Week 11 - Pathophysiology & Pharmacology of Seizures

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Published	10/01/2024	A 47-year-old male patient is having seizures that last from 30-120 sec. Following his seizures he has weakness for hours. He has a brief warning befo…
Published	10/01/2024	Overstimulation of what neuronal type is most likely to lead to neuronal death through excess calcium entry into neurons (excitotoxicity)?A. Neurons t…
Published	10/01/2024	The metabolism of which drug listed below can become saturated at high doses?A. CarbamazepineB. EthosuximideC. LamotrigineD. PhenobarbitalE. Phenytoin…
Published	10/01/2024	A 4-year-old girl is having repeated episodes of sudden onset seizures that last for approximately 10 seconds. An EEG is performed which revealed an a…
Published	10/01/2024	Which of the following is correctly matched? Drug :Mechanism of action or toxicityA. Carbamazepine: activates GABA-A, chloride channels B. Ethosuximid…
Published	10/01/2024	A 35-year-old woman being treated, for pain caused by trigeminal neuralgia, with an anti-seizure medication is cautioned to use another form of birth …
Published	10/01/2024	A 47-year-old man is unconscious and is having continuous seizure activity for at least 30 minutes. Which drug would you use first to stop this patien…
Published	10/01/2024	A 35-year-old woman is suffering from temporal lobe or complex partial epilepsy and has been having frequent episodes of seizure activity. Which of th…
Published	10/01/2024	A 35-year-old woman undergoing epilepsy treatment is cautioned to use another form of birth control besides oral contraceptives because her anti-epile…
Published	10/01/2024	A 46-year-old man is being treated for his bipolar disorder with a drug that increases the inactivation of sodium channels.A. PhenytoinB. ClonazepamC.…
Published	10/01/2024	Which of the following medication has a mechanism of action that may include blockade of NMDA receptors and is effective for treating partial seizure …
Published	10/01/2024	Which statement is true regarding Carbamazepine? If A-D are correct mark E!A. Carbamazepine is used to treat trigeminal neuralgiaB. Carbamazepine is a…
Published	10/01/2024	Which statement is true? If all statements A-D are correct mark E!A. Phenytoin prevents the metabolism of oral steroids B. Phenytoin is sometimes diss…
Published	10/01/2024	A first grade teacher notices that her student becomes inattentive and stares off into space before resuming his activities. This occurs several times…
Published	10/01/2024	Which of the following is NOT correctly matched?A. Felbamate:is associated with aplastic anemiaB. Gabapentin: antiseizure medication also used for neu…
Published	10/01/2024	A 35-year-old woman is diagnosed with myoclonic seizures. She is treated with a drug that requires monitoring liver function test (LFTs), is not assoc…
Published	10/01/2024	Status epilepticus should be treated promptly with (if A-D are correct mark E)A. DiazepamB. Phenobarbital if unresponsive to benzodiazepinesC. A gener…
Published	10/01/2024	Drugs of choice for treating grand mal and partial seizure disorders most likely work through which of the following mechanisms?A. Increase cation inf…
Published	10/01/2024	Which drug is correctly matched?A. Carbamazepine: is structurally similar to valproic acid B. Ethosuximide: reduces low-threshold (T-type) Ca++ curren…
Published	10/01/2024	A 22-year-old college student applies a cream containing lidocaine to her legs prior to driving a laser-hair-removal salon. Unfortunately she does not…
Published	10/01/2024	A 24-year-old woman presents with a seizure disorder characterized by tonic rigidity lasting 15-30 seconds followed by a tremor that progresses into c…
Published	10/01/2024	A 54-year-old male diabetic patient is complaining of an unusual burning and tingling pain that is triggered by light touch. His physician determines …
Published	10/08/2024	{{c1::Pyramidal}} cells are the excitatory cells in the cortex
Published	10/08/2024	{{c1::Basket}} cells are the inhibitory cells in the cortex
Published	10/08/2024	Tonic-clonic seizures are characterized by alternations in {{c1::GABAergic}} and {{c1::glutamatergic}} activity
Published	10/08/2024	At low doses, phenytoin exhibits {{c1::first}}-order kinetics
Published	10/08/2024	At therapeutic doses, phenytoin exhibits {{c1::zero}}-order kinetics
Published	10/08/2024	{{c1::Fosphenytoin}} is the soluble and less cardiotoxic form of phenytoin
Published	10/08/2024	Which anti-epileptics increase the metabolism of oral contraceptives?{{c1::Carbamzepine, phenytoin, and topiramate::3}}
Published	10/08/2024	{{c1::Carbamazepine}} is an anti-epileptic that inhibits the reuptake of catecholamines
Published	10/08/2024	Lamotrigine is first-line treatment for all types of seizures except {{c1::absence}} seizures
Published	10/08/2024	Additional effects of valproic acid include increasing {{c1::K+}} channel conductance and and blocking {{c1::T-type Ca2+}} channels
Published	10/08/2024	Felbamate is an anti-epileptic that exerts its effects by increasing {{c1::GABAergic transmission}}
Published	10/08/2024	{{c1::Felbamate}} is an anti-epileptic associated with {{c2::aplastic anemia}} and {{c3::hepatitis}}
Published	10/08/2024	{{c1::Vigabatrin}} is an anti-epipletic that can be used to treat infantile spasm in conjunction with corticotropin and prednisone
Published	10/08/2024	What type(s) of seizure(s) may be treated with gabapentin?{{c1::Focal (partial)*::Focal (partial), tonic-clonic, or absence}}
Published	10/08/2024	{{c1::Clonazepam}} is an sedative that can be used to treat infantile spasm in conjunction with ACTH and prednisone
Published	10/08/2024	What type(s) of seizure(s) may be treated with clonazepam?{{c1::Absence::Focal (partial), tonic-clonic, or absence}}
Published	10/08/2024	{{c1::Clorazepate}} is a sedative that can be used as adjunct therapy for {{c2::complex focal}} seizures
Published	10/08/2024	One hematologic adverse effect associated with ethosuximide is {{c1::myelosuppression}}
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