Notes in L04 - Cell signalling and Cancer

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Published	02/02/2025	How can signalling molecules interact with cells? What does this depend on?What is the definition of intracellular signalling?What signalling events c…
Published	02/02/2025	How do signalling pathways work?What are their shared properties?
Published	02/02/2025	What enzymes mediate phosphorylation?What type of modification is phosphorylation?What residues does phosphorylation occur on? How is this linked to e…
Published	02/02/2025	What are receptor tyrosine kinases? How do they work?What is their structure?What does growth factor binding cause in them?What are some examples of s…
Published	02/02/2025	What is the MAPK pathway? What is one possible driving signal?Give a summary of the steps.
Published	02/02/2025	How does the Grb2 and Sos bit of the MAPK pathway work?How does the Ras bit work?
Published	02/02/2025	What are the different Ras genes?What do they encode for?What do they contain?Why is it famous?How does its basic function work? (4 steps)
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Published	02/02/2025	How to turn off the MAPK pathway?What are some MAPK mutations that lead to cancer? Give examples. Where are they common?
Published	02/02/2025	Give a summary of the PI3K pathway
Published	02/02/2025	How does PIP3 activate mTORC1?
Published	02/02/2025	How can you turn off the PI3K pathway?What does this lead to?
Published	02/02/2025	What are common mutations that affect RTKs?What are their consequences?How can we block RTKs with DRUGS?Which RTK do we target in breast cancer patien…
Published	02/02/2025	What are the two main bodies used to target HER2?How do they work? How else can we target it? How does this work?How can patients become resistant to …
Published	02/02/2025	What is BCR?What is ABL?How do they fuse together and what does this create?What does this lead to?What mutation leads to the expression of BCR-ABL? I…
Published	02/02/2025	What is an example of a BCR-ABL inhibitor?How does it work?How succesful is it?What patients may have a resistance?
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