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PNS Development
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Published
11/30/2024
The peripheral nervous system (PNS) consists of {{c1::cranial}} nerves, {{c1::spinal}} nerves, and {{c1::autonomic}} nerves along with their asso…
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The peripheral nervous system (PNS) developmentally arises from- {{c1::Neural crest cells (primary contribution)}}- {{c1::Neural tube (minor contribut…
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The PNS cranial region forms {{c1::before::before/after}} the more caudal regions
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Neurulation is a process which includes the inductive events that transform the {{c1::neuroectoderm}} to a {{c1::neural plate}} and ultimately to {{c1…
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Neurulation categories:- {{c1::Primary Neurulation}}- {{c1::Secondary Neurulation}}
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Primary neurulation location: {{c1::Rostral to S2}}
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Secondary neurulation location: {{c1::S2-Co1}}
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Primary neurulation timeframe: week {{c1::3-4}}
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Primary neurulation begins at the {{c1::4th-6th}} somites
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Neural plate forms on the {{c1::posterior aspect::location}} of the trilaminar embryo
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Neural plate has formed by day {{c1::18}}
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The {{c1::notochord}} induces the overlying {{c1::ectoderm}} to differentiate into the {{c2::neural plate}}
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Neural tube folding results in formation of: {{c1::neural tube}} and {{c1::neural crest}}
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The {{c1::neural tube}} will ultimately form the {{c2::central nervous system (CNS).}}
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The {{c1::center of the neural tube (neural canal)}} will ultimately form the {{c2:: ventricular system and central canal of the spinal cord.}}
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The first neural fold fusion occurs at {{c1::future hindbrain-cervical junction (near future foramen magnum)::location}} on day {{c2::22}}
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Neural fold fusion proceeds {{c1::both rostrally and caudally::direction}} from site of first fusion
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Cranial {{c1::two-thirds::fraction}} of neural plate and tube ultimately becomes the {{c1::future brain}}
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Caudal {{c1::one-third::fraction}} of neural plate and tube ultimately becomes the {{c1::spinal cord}}
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Neuropores: {{c1::unfused portions at the cranial and caudal ends of neural plate and tube}}
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{{c1::Closure of the neuropores}} marks the end of primary neurulation
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Secondary neurulation mainly involves the {{c1::caudal eminence or medullary cord::structure}} which arises from the {{c2::diminishing primitive strea…
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{{c2::Canalization}} is the process by which {{c1::caudal eminence (medullary cord)::structure}} forms {{c1::vacuoles (spaces)}} that merge to fo…
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{{c2::medullary cord}} gives rise to the {{c1::sacral and coccygeal segments}} of the spinal cord including {{c1::conus medullaris.}}
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The {{c1::medullary cord}} ultimately combines with the {{c1::neural tube}} to form the {{c2::continuous structure of the spinal cord}}
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Neural crest cells (NCCs) arise from {{c1::the dorsal part::location}} of the {{c1::developing neural tube::structure}} during the process of neurulat…
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Neural crest cells (NCCs) undergo an {{c1::epithelial::cell type}} to {{c1::mesenchymal::cell type}} transformation as they undergo {{c2::delamin…
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Delamination of neural crest cells (NCCs): {{c1::The process of NCCs detaching from the neural tube}}
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Neural crest cells (NCCs) ultimately become:- {{c1::Arachnoid mater}}- {{c1::Most of craniofacial bones}}- {{c1::Dorsal root ganglia}}- …
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Detachment and migration of the neural crest cells occurs {{c1::craniocaudally::direction}} from {{c2::mesencephalon::location}} to {{c2::th…
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Inappropriate migration of {{c2::neural crest cells (NCCs)}} can contribute to {{c1::tumorigenesis::cancer process}} and {{c1::metastasis::cancer…
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Dorsal root ganglia ultimately formed from {{c1::neural crest cells}}
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Autonomic system ganglia ultimately formed from {{c1::neural crest cells}}
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Arachnoid mater ultimately formed from {{c1::neural crest cells}}
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Adrenal medulla cells ultimately formed from {{c1::neural crest cells}}
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Dorsal horn of the spinal cord ultimately formed from {{c1::neural tube}}
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Dorsal horn of the spinal cord ultimately formed from {{c1::neural tube}}
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Craniofacial bony structures ultimately formed from {{c1::neural crest cells}}
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Melanocytes ultimately formed from {{c1::neural crest cells}}
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Ventral horn of the spinal cord ultimately formed from {{c1::neural tube}}
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Lateral horns of the spinal cord ultimately formed from {{c1::neural tube}}
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Cerebellum ultimately formed from {{c1::neural tube}}
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Medulla oblongota ultimately formed from {{c1::neural tube}}
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Pia mater ultimately formed from {{c1::neural crest cells}}
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Anterior neuropore closes by day {{c1::25}}
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Posterior neuropore closes by day {{c1::27}}
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cuneocerebellar tract is in the {{c1::dorsal (fasciculus cuneatus)}} fasciculus and contains {{c1::ascending::ascending/descending}} axons that carry …
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