Notes in 10 Pharmacodynamics

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Published	12/13/2023	{{c1::Competitive}} antagonists are reversible, while {{c1::noncompetitive}} antagonists are not reversible.
Published	12/13/2023	The therapeutic index is calculated as {{c1::LD50 / ED50}}
Published	12/13/2023	The therapeutic window is the range between the {{c1::minimum toxic}} dose and the {{c1::minimum therapeutic}} dose.
Published	12/13/2023	Chronic exposure to endogenous ligands can cause {{c1::downregulation}} of receptors.
Published	12/13/2023	On the dose-response curve, the x-axis represents {{c1::potency}}.
Published	12/13/2023	On the dose-response curve, the y-axis represents {{c1::efficacy}}.
Published	12/13/2023	The {{c1::ED50}} is the dose required to achieve an effect in 50% of the population.
Published	12/13/2023	A {{c1::left::left/right}} shift in the dose-response curve is associated with {{c2::increased::increased/decreased}} potency.
Published	12/13/2023	A {{c1::right::left/right}} shift in the dose-response curve is associated with {{c2::decreased::increased/decreased}} potency.
Published	12/13/2023	{{c1::Potency}} is the dose required to achieve a given clinical effect.
Published	12/13/2023	{{c1::Efficacy}} is the intrinsic ability of a drug to elicit a given clinical effect.
Published	12/13/2023	Once the plateau phase of a dose-response curve is reached, additional drug causes {{c1::toxicity}}.
Published	12/13/2023	A {{c1::steep::shallow/steep}} slope on the dose-response curve implies that {{c2::more::more/less}} receptors must be occupied before a clinical resp…
Published	12/13/2023	{{c1::Individual variability}} refers to the difference of clinical effects a given dose elicits in different patients.
Published	12/13/2023	Curve 1: {{c1::Full agonist}}
Published	12/13/2023	Curve 2: {{c1::Partial agonist}}
Published	12/13/2023	Curve 3: {{c1::Antagonist}}
Published	12/13/2023	Curve 4: {{c1::Inverse agonist}}
Published	12/13/2023	{{c1::Addition}} - effect of two drugs given together are added to each other.
Published	12/13/2023	{{c1::Synergism}} - effect of two drugs given together is greater than the sum of individual effects
Published	12/13/2023	{{c1::Potentiation}} - effect of one drug is enhanced by a drug that has no effect on its own
Published	12/13/2023	{{c1::Antagonism}} - effect of two drugs cancel each other out
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