Notes in CH4

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Status	Last Update	Fields
Published	12/07/2023	What is the definition of an induced fit
Published	12/07/2023	Hemoglobin has a {{c1::sigmoid}} (cooperative) bending curve
Published	12/07/2023	The binding of 1 O2 molecule increases/decreases the affinity to bind another O2
Published	12/07/2023	The 4th O2 binds with {{c1::100}} fold greater affinity than the 1st O2
Published	12/07/2023	hemoglobin in lungs has higher affinity to O2 in lungs than tissues T or F
Published	12/07/2023	Which conformation state of hemoglobin has higher affinity
Published	12/07/2023	what does allosteric protein mean
Published	12/07/2023	What kind of curve is the result of cooperative binding
Published	12/07/2023	How do the different ligand binding sites on the same multimeric protein molecule communicate
Published	12/07/2023	O2 binding triggers a {{c1::T}} state to {{c2::R}} state conformational change
Published	12/07/2023	Deoxyhemoglobin units are more stable in {{c1::T}} state
Published	12/07/2023	Describe the conformational change from T state to R state
Published	12/07/2023	The binding of O2 causes the heme group to assume a more planar/linear conformation
Published	12/07/2023	Oxygenation cause one alphabeta dimer to rotate {{c1::15}} degrees with respect to the other dimer
Published	12/07/2023	what is Hill equation
Published	12/07/2023	when n {{c1:: =}} 1, no cooperativity
Published	12/07/2023	When n {{c1::> }}1, positive cooperativity
Published	12/07/2023	When n {{c1::< }}1, negative cooperativity
Published	12/07/2023	in addition to O2, hemoglobin also transports {{c1::H+}} and {{c1::CO2}} from the tissues to the lungs and kidneys
Published	12/07/2023	What is the Bohr effect
Published	12/07/2023	What happens at a low pH in bohr effect
Published	12/07/2023	what happens at a high CO2 in bohr effect
Published	12/07/2023	what destabilises the deoxyhemoglobin molecule and decreases its affinity for oxygen
Published	12/07/2023	what happens when deoxyhemoglobin molecule is destabilised, it facilitates the release of oxygen in the peripheral tissues
Published	12/07/2023	how does the ph of blood in lung affect hemoglobin
Published	12/07/2023	How does the ph of blood in tissue affect hemoglobin
Published	12/07/2023	Why do hemoglobins carry away CO2 from tissues
Published	12/07/2023	How are CO2 exported
Published	12/07/2023	What does formation of a carbamate yield, what does it do
Published	12/07/2023	The reaction of producing CO2 to bicarbonate is catalysed by what
Published	12/07/2023	How does bisphosphoglycerate stabilise the T state if Hb
Published	12/07/2023	Where is high concentrations of BGP found
Published	12/07/2023	Hemoglobin binds to oxygen quite tightley when BPG is absent/present
Published	12/07/2023	Which situations do BPG levels increase
Published	12/07/2023	Why must a fetal hemoglobin have greater affinity than the maternal hemoglobin for O2
Published	12/07/2023	Why does fetal hemoglobin have lower affinity for BPG than normal hemoglobin
Published	12/07/2023	which amino acid mutation leads to sickle cell anemia
Published	12/07/2023	Effect of Val on Hb
Published	12/07/2023	What do heterozygous individuals of sickle cell anemia exhibit
Published	12/07/2023	What happens when HbS become deoxygenated
Status	Last Update	Fields