Notes in 04_Transplantation

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Status	Last Update	Fields
Published	02/10/2024	{{c1::Rejection}} refers to {{c2::damage done by the immune system to a transplanted organ}}
Published	02/10/2024	{{c1::Autologous transplant}} refers to {{c2::tissue returning to the same individual after a period outside the body, usually in a frozen state}}
Published	02/10/2024	{{c1::Syngeneic/Isograft transplant}} refers to {{c2::transplant between identical twins; there is usually no problem with graft rejection}}
Published	02/10/2024	{{c1::Allogeneic transplant}} refers to {{c2::transplant that takes place between genetically nonidentical members of the same species; there is alway…
Published	02/10/2024	{{c1::Cadaveric transplantation}} is {{c2::transplanting organs from a dead donor}}
Published	02/10/2024	{{c1::Xenogeneic transplant}} is {{c2::transplantation that takes place between different species and carries the highest risk of rejection}}
Published	02/10/2024	Criteria for Transplantation {{c1::There must be good evidence that the damage is irreversible}} {{c1::That alternative treatments are not applicable}…
Published	02/10/2024	Methods to Minimize Risk of Rejection of Transplantation {{c1::The donor and recipient must be ABO compatible}} {{c1::The recipient must not have anti…
Published	02/10/2024	{{c1::Hyperacute Rejection}} is {{c2::rejection of transplantation within minutes to hours due to preformed antibodies binding to either ABO blood gro…
Published	02/10/2024	{{c1::Acute Rejection}} is {{c2::rejection of transplantation within days to weeks due to CD8/CD4 T cells activated against donor HLA triggering a typ…
Published	02/10/2024	{{c1::Chronic Rejection}} is {{c2::rejection of transplantation within months to years due to CD4 T cells responding to recipient APCs presenting dono…
Published	02/10/2024	{{c1::Transplant Tolerance}} is a {{c2::state of unresponsiveness to molecules the immune system has the capacity to recognize and attack, meaning in …
Published	02/10/2024	Tissue Typing Techniques[1] {{c1::HLA typing (Identify HLA variations)}}[2] {{c1::HLA cross matching (Mixture of donor blood with recipient serum…
Published	02/10/2024	In HLA typing, a donor must match a minimum of {{c1::6}} HLA markers
Published	02/10/2024	{{c2::HLA cross matching}} is done to detect {{c1::antibodies}} against HLA and potentially other polymorphic alloantigens
Published	02/10/2024	Sources of Stem Cells{{c1::Bone Marrow}}{{c1::Peripheral Blood}}{{c1::Cord Blood}}
Published	02/10/2024	{{c1::Stem Cell Transplantation}} involves {{c2::transplantation of hematopoietic stem cells to restore myeloid and lymphoid cells}}
Published	02/10/2024	{{c1::Autologous Stem Cell Transplantation}} is a {{c2::type of transplantation where the marrow is removed, frozen, and reinfused after potent c…
Published	02/10/2024	{{c1::Allogenic Stem Cell Transplantation}} is {{c2::transplantation of stem cells from members of the same species, which is a much riskier procedure…
Published	02/10/2024	Indications of Allogenic Stem Cell Transplantation {{c1::Haematologic malignancy with no alternative treatment options}} {{c1::Cases when myeloid cell…
Published	02/10/2024	Conditioning and Treatment Prior to Autologous Stem Cell Transplantation{{c1::the patient receives high dose chemotherapy with/without radiation thera…
Published	02/10/2024	Conditioning and Treatment Prior to Allogenic Stem Cell Transplantation{{c1::the patient receives high dose chemotherapy with/without radiation therap…
Published	02/10/2024	{{c1::Graft Versus Host Disease (GvHD)}} is {{c2::a fatal type IV hypersensitivity reaction that occurs when grafted immunocompetent T cells (from bon…
Published	02/10/2024	Prevention of Hyperacute and Acute Rejection is via {{c1::Careful ABO}} and {{c1::HLA cross-matching}}
Published	02/10/2024	Prevention of Graft versus Host Disease (GvHD)Usage of {{c1::immunosuppressive drugs}} even if the donor and recipient are HLA identical
Status	Last Update	Fields