Notes in OG9.3 PCOS

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Published	10/04/2024	PCOS was first described in 19{{c1::53}}
Published	10/04/2024	Having ≥ 2 of the following {{c1::Rotterdam}} criteria for PCOS is sufficient for diagnosis: – {{c2::Biochemical or clinical evidence of hyperand…
Published	10/04/2024	PCOS in slim women is thought to be driven by {{c1::LH }}
Published	10/04/2024	PCOS in overweight women is thought to be driven by {{c1::insulin amplification }}
Published	10/04/2024	Most common endocrine disorder affecting women is {{c1::PCOS }}
Published	10/04/2024	{{c1::Oligomenorrhea }}: {{c2::Menstruation at intervals > 35 days}}
Published	10/04/2024	{{c1::Secondary amenorrhea }}: {{c2::absence of menorrhea for > 6 months}}
Published	10/04/2024	Infertility in PCOS is due to {{c1::anovulation }}
Published	10/04/2024	Does PCOS present with virilisation?{{c1::No}}
Published	10/04/2024	{{c1::Hirsuitism}}: {{c2::Excess body hair in a male distribution pattern – upper lip, chin, around nipples, lower abdomen, back, buttocks}} &nbs…
Published	10/04/2024	Hirsuitism is graded by the {{c1::Ferriman-Gallwey }} system
Published	10/04/2024	Ferriman-Gallwey system for hirsuitism < {{c1::8}} is {{c2::normal }}
Published	10/04/2024	Ferriman-Gallwey system for hirsuitism {{c1::8 - 15::score}} is {{c2::mild hirsuitism }}
Published	10/04/2024	Ferriman-Gallwey system for hirsuitism {{c1::> 15::score}} is {{c2::severe hirsuitism }}
Published	10/04/2024	–Breast atrophy –Increased muscle mass –Severe hirsutism of rapid onset –Male pattern balding –Deep voice –CliteromegalyThese are signs of {{c1::…
Published	10/04/2024	Virilization is usually caused by {{c1::adrenal tumours }}
Published	10/04/2024	If a patient with suspected PCOS is amenorrheic, {{c1::late onset CAH }} must be excluded
Published	10/04/2024	Total testosterone > 5 nmol/L warrants further investigation as it suggests → {{c1::adrenal tumour }}
Published	10/04/2024	PCOS has ↑ {{c1::LH::LH/FSH}} and ⟷ {{c1::FSH::LH/FSH }}
Published	10/04/2024	PCOS has {{c1::↓}} sex hormone binding globulin
Published	10/04/2024	An ovary with {{c1::≥ 12}} follicles measuring {{c1::2 - 9::range}} mm in diameter and/or increased ovarian volume (> {{c2::103)}} is con…
Published	10/04/2024	{{c1::PCOS}} causes 80 - 90% of anovulatory infertility
Published	10/04/2024	Give patients with PCOS and irregular/heavy menses {{c1::COCPs }}
Published	10/04/2024	If a patient with PCOS has < 1 period every 3 months, give {{c1::LNG-IUS (levonorgestrel intrauterine system)}} or induce {{c1::withdrawa…
Published	10/04/2024	In a patient with PCOS, do a glucose tolerance test if:- BMI > {{c1::30 }}- Age > {{c1::40 }}- Pregnant at {{c1::24 - 28 weeks }}
Published	10/04/2024	Indication for bariatric surgery/anti-obesity RXs in a woman with PCOS:- {{c1::BMI > 35 }}
Published	10/04/2024	Patients with PCOS should not get treatment for infertility until {{c1::BMI < 35::BMI}}
Published	10/04/2024	Methods to induce withdrawal bleeds in PCOS (to prevent endometrial hyperplasia/cancer){{c1::cyclical progesterone}} every 2 months (ex: {{c1::Duphast…
Published	10/04/2024	Agents for ovulatory induction in PCOS = {{c1::letrozole}}, {{c1::clomiphene}}, +/- {{c1::metformin}}
Published	10/04/2024	Treating infertility in PCOS1st line = {{c1::ovulatory induction with letrozole or clomiphene, +/- metformin}}2nd line = {{c1::parenteral gonadotrophi…
Published	10/04/2024	{{c1::8-13::range}}% of reproductive age women have PCOS
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