Notes in Nephrotic Syndrome

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Published	10/08/2024	Nephrotic Syndrome most common between the ages of 2 and 5 years.It presents with {{c1::frothy urine}}, {{c1::generalised oedema}} and {{c1::pall…
Published	10/08/2024	The most common cause of nephrotic syndrome in children is {{c1::minimal change disease}}, causing over 90% of cases in children under 10. &nb…
Published	10/08/2024	{{c1::Minimal change disease}} is the most common cause of nephrotic syndrome in children.
Published	10/08/2024	A renal {{c1::biopsy}} and standard {{c1::microscopy}} in minimal change disease is usually not able to detect any abnormality. Urinalysis&nbs…
Published	10/08/2024	Management of minimal change disease is with {{c1::corticosteroids}} (i.e. {{c1::prednisolone}}).
Published	10/08/2024	Nephrotic syndrome occurs when the basement membrane in the glomerulus becomes highly permeable to {{c1::protein}},…
Published	10/08/2024	Nephrotic syndrome features a classic triad of:• {{c1::Hypoalbuminemia}}• {{c1::Significant proteinuria}} • {{c1::Oedema}} Three other featu…
Published	10/08/2024	Nephrotic syndrome can be secondary to intrinsic kidney disease: • {{c1::Focal segmental glomerulosclerosis}}• {{c1::Membranoproliferative glomer…
Published	10/08/2024	Nephrotic syndrome can be secondary to an underlying systemic illness, for example: • {{c1::Henoch-Schonlein purpura (HSP)}}• {{c1::Diabetes}}• I…
Published	10/08/2024	Nephrotic syndrome Management: • {{c1::Albumin}} infusions may be required in severe hypoalbuminaemia• {{c1::Diuretics}} may be used to trea…
Published	10/08/2024	Nephrotic syndrome Management: High dose steroids are given for {{c1::4}} weeks and then gradually weaned over the next {{c1::8}} …
Published	10/08/2024	Management of Nephrotic syndrome In steroid resistant children, {{c1::ACE inhibitors}} and {{c1::immunosuppressants}}&nb…
Published	10/08/2024	Complications of Nephrotic Syndrome{{c1::Hypovolaemia}}due to fluid leaking from intravascular space into interstitial spacecausing {{c2::oedema}} &am…
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