Notes in CH3

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Status	Last Update	Fields
Published	12/07/2023	what element(s) is bonded to the Fe2 in a heme group
Published	12/07/2023	what is the organic ring stucture of a heme group called
Published	12/07/2023	Why cant the Fe2 in heme group be Fe3
Published	12/07/2023	how is fe2 oxidation prevented in heme containing proteins
Published	12/07/2023	what is the Ka of protein-ligand binding equilibrium expression
Published	12/07/2023	what is a ligand
Published	12/07/2023	What is the binding site
Published	12/07/2023	what bindings do ligands use
Published	12/07/2023	history of the 3 protein ligand binding models
Published	12/07/2023	what is the equation and the unit of kd when the equation is first order
Published	12/07/2023	What is the equation and unit when the reaction is second order
Published	12/07/2023	ratio of bound to free protein is directly proportional/inproportional to the concentration of free ligand
Published	12/07/2023	What happens to the concentration of free ligand when the concentration of the ligand is much greater than the concentration of ligand-binding sites
Published	12/07/2023	What is the equation of Y (ligand-binding sites on the protein that are occupied by ligand)
Published	12/07/2023	most drugs are developed by optimising the inhibition of {{c1::protein targets}}
Published	12/07/2023	What are signaling molecules
Published	12/07/2023	how do most small molecule drugs work
Published	12/07/2023	What happens to the target proteins when drugs are bound to them
Published	12/07/2023	simplified expression of fractional occupancy
Published	12/07/2023	what does the fraction of bound sites depend on
Published	12/07/2023	When [L] = Kd, f = {{c1::0.5}}
Published	12/07/2023	for 90% of the availbale ligand-binding sites to be occupied, [L], must be {{c1::9}} times greater than Kd
Published	12/07/2023	Lower value of Kd corresponds to what (in terms of affinity)
Published	12/07/2023	What does it mean when the protein has reached half saturation
Published	12/07/2023	what does affinity mean
Published	12/07/2023	The more negative the value of free energy of formation of the complex delta G, the {{c1::higher}} the affinity
Published	12/07/2023	What does specificity mean
Published	12/07/2023	Relationship between Gibbs free energy and receptor-ligand complex quantitatively
Published	12/07/2023	Magnitude of strong binding is
Published	12/07/2023	Magnitude of weak binding is
Published	12/07/2023	What happens in a heme group when O is not present
Published	12/07/2023	What is used instead of Kd in myglobin oxygen curve
Published	12/07/2023	What is fractional occupancy of myoglobin
Published	12/07/2023	{{c1::Carbon monoxide}} binds to free heme molecules 20,000 times better than O2
Published	12/07/2023	when does a carbon monoxide only bind 40 times better than O2 to a heme group
Published	12/07/2023	Why does affinity of O2 increase when heme is bound to myoglobin
Published	12/07/2023	Why does O2 affinity increase so much when heme is bound in myglobin
Published	12/07/2023	Why is a linear molecule CO forced to adopt a slight angle to bind to heme group
Status	Last Update	Fields