Notes in LE004 Population Genetics

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Published	10/03/2024	What is the Hardy-Weinberg equilibrium equation?
Published	10/03/2024	What are the six assumptions of Hardy-Weinberg equilibrium?
Published	10/03/2024	Define population genetics
Published	10/03/2024	Define selection
Published	10/03/2024	How did selection drive the sickle cell heterozygosity?
Published	10/03/2024	What are the four mechanisms of adaptation and selection?
Published	10/03/2024	Define hard sweep
Published	10/03/2024	Define soft sweep
Published	10/03/2024	What are the two types of soft sweep?
Published	10/03/2024	What is polygenic adaptation?
Published	10/03/2024	What is adaptive introgression?
Published	10/03/2024	Define genetic drift
Published	10/03/2024	Genetic drift is more pronounced in {{c1::small populations}} rather than large populations
Published	10/03/2024	How does Genome Wide Association Studies (GWAS) work?
Published	10/03/2024	Explain the axes of a manhattan plot
Published	10/03/2024	Define allele frequency spectrum
Published	10/03/2024	What are three ways to identify variants under selection?
Published	10/03/2024	Define extended haplotype homozygosity
Published	10/03/2024	A {{c1::polygenic score}} including a genome-wide set of SNPs can identify individuals with risk equivalent to a monogenic mutatio…
Published	10/03/2024	A polygenic score including a {{c1::genome-wide set of SNPs}} can identify individuals with risk equivalent to a monogenic mu…
Published	10/03/2024	A polygenic score including a genome-wide set of SNPscan identify individuals with risk {{c1::equivalent }}to a monogenic mut…
Published	10/03/2024	Define polygenic risk score
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