Notes in Modified Release Dosage Forms

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Published	11/06/2023	Modified Release Dosage Forms Slides 4 and 6modified by {{c1::time}}, {{c1::rate}}, or {{c1::location}} of drug releaseexamples{{c2::extended}}-releas…
Published	11/06/2023	Other Terms used for Modified Release Slide 6{{c1::Extended}}-action {{c1::Sustained}}-action {{c1::Prolonged}}-action {{c1::Repeat}}-a…
Published	11/06/2023	Terminology Slide 7Prolonged: released over an {{c1::extended amount of time}}Sustained: releases a {{c1::loading dose}} first, followed by {{c1::slow…
Published	11/06/2023	Pharmacokinetics vs Pharmacodynamics Slide 9Pharmacokinetics{{c1::absorption, distribution, metabolism, and excretion + time}}Pharmacodynamics{{c1::ef…
Published	11/06/2023	Drug Release and Therapeutic Effectsdrugs can only be {{c1::absorbed}} when {{c1::released and dissolved}} in biological fluidsdrugs {{c1::cannot&nbsp…
Published	11/06/2023	Conditions for Drug Actiondrug must be {{c1::absorbed}} after it is {{c1::dissolved}} or {{c1::in solution}}drug must exert its effect via {{c1::molec…
Published	11/06/2023	In Vitro vs In Vivo Slide 12in vivo = {{c1::in organism/organ system}}in vitro = {{c1::in glass}}
Published	11/06/2023	Drug Release and Drug Blood Concentration ProfileImmediate ReleaseIn Vitro: {{c1::large inital release followed by non-changing concentration over tim…
Published	11/06/2023	Modifed Release Products and Routes of Administration Slide 15OralConventional: {{c1::marked by initial increase over time and decrease over time due …
Published	11/06/2023	Pharmacological Effects Slide 16constant effectdue to {{c1::constant concentration over time}}periodic effectdue to {{c1::periodic increases in concen…
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